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Chlorpromazine, Methamphetamine, Serotonin, Reserpine, and Effects on Cat Spinal Cord

Chlorpromazine, Methamphetamine, Serotonin, Reserpine, and Effects on Cat Spinal Cord Abstract There is an increasing interest in drugs which have a central nervous system action, but the pharmacology of these agents appears to be more complex than some of the published reports indicate. Data from a single screening technique have often been interpreted as indicating a specific action on a certain level of the nervous system, apparently disregarding the fact that there are many physiological variables operating simultaneously and possible effects at other levels of nervous system organization. In the following studies the effects on the monosynaptic and multisynaptic reflex responses of five currently important psychiatric compounds were investigated. These spinal cord reflex systems are comparatively simple ones and thereby allow interpretations of results based on previously known anatomical and physiological data. The studies were designed to yield qualitative data about drug action on a synaptic level and to demonstrate the usefulness of a new technique to analyze further the site References 1. Edisen, A. E. U.: Am. J. Physiol. 184:223-232, 1956. 2. Schneider, J. A.; Plummer, A. J.; Earl, A. E., and Gaunt, R.: Bull. New York Acad. Sc. 61:17-26, 1955.Crossref 3. Dasgupta, S. R., and Werner, G.: Arch. internat. pharmacodyn. 100:409-417, 1955. 4. Coraboeuf, E.; Lavigne, S.; Distel, R., and Boistel, J.: Compt. rend. Soc. biol. 149:58-61, 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

Chlorpromazine, Methamphetamine, Serotonin, Reserpine, and Effects on Cat Spinal Cord

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1958.02340030087014
Publisher site
See Article on Publisher Site

Abstract

Abstract There is an increasing interest in drugs which have a central nervous system action, but the pharmacology of these agents appears to be more complex than some of the published reports indicate. Data from a single screening technique have often been interpreted as indicating a specific action on a certain level of the nervous system, apparently disregarding the fact that there are many physiological variables operating simultaneously and possible effects at other levels of nervous system organization. In the following studies the effects on the monosynaptic and multisynaptic reflex responses of five currently important psychiatric compounds were investigated. These spinal cord reflex systems are comparatively simple ones and thereby allow interpretations of results based on previously known anatomical and physiological data. The studies were designed to yield qualitative data about drug action on a synaptic level and to demonstrate the usefulness of a new technique to analyze further the site References 1. Edisen, A. E. U.: Am. J. Physiol. 184:223-232, 1956. 2. Schneider, J. A.; Plummer, A. J.; Earl, A. E., and Gaunt, R.: Bull. New York Acad. Sc. 61:17-26, 1955.Crossref 3. Dasgupta, S. R., and Werner, G.: Arch. internat. pharmacodyn. 100:409-417, 1955. 4. Coraboeuf, E.; Lavigne, S.; Distel, R., and Boistel, J.: Compt. rend. Soc. biol. 149:58-61, 1955.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Mar 1, 1958

References