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Chlorpromazine and Communication Processes

Chlorpromazine and Communication Processes Abstract Introduction The favorable results that have been attributed to ataractic drugs in the treatment of chronic schizophrenic patients have led to numerous investigations to determine the psychological action of these agents. "Objective" studies designed to assess psychological effects occurring with such drug therapy have demonstrated few significant changes. "Subjective" clinical methods commonly employed are vulnerable to bias, as shown by Feldman.3 Some reported results are open to question because of faulty experimental design. As an applicable research design, the "double-blind" approach has important shortcomings, most noteworthy of which is that the investigator is seldom unaware of the drug group. Hall and Dunlap,5 using a double-blind approach, administered chlorpromazine in individually determined doses, up to 600 mg. daily, to a large number of semidisturbed schizophrenic patients and found significant improvement at the 5% level on subjective ratings by psychiatrists and a psychologist. However, agreement between raters was attained only References 1. Ammons, R. B., and Ammons, H. S.: Full Range Picture Vocabulary Test , Louisville, Ky., Psychological Test Specialists, 1948. 2. Becktoldt, H. P.: A Factorial Investigation of the Perceptual Speed Factor , Am. Psychologist 2:304-305, 1947. 3. Feldman, P. R.: The Personal Element in Psychiatric Research , Am. J. Psychiat. 113:52-54, 1956. 4. Finkelstein, M.; Gerboth, R., and Westerhold, R.: Standardization of a Short Form of the Wechsler Vocabulary Subtest , J. Clin. Psychol. 8:133-135, 1952.Crossref 5. Hall, R. A., and Dunlap, D. J.: A Study of Chlorpromazine: Methodology and Results with Semi-Disturbed Schizophrenics , J. Nerv. & Ment. Dis. 122:301-314, 1955. 6. Kinross-Wright, V.: Chlorpromazine Treatment of Mental Disorders , Am. J. Psychiat. 111: 907-912, 1955. 7. O'Connor, J.: Born That Way , Human Relation Series 7, Baltimore, Williams & Wilkins Company, 1928, pp. 225-310. 8. Pearl, D.: James Quinter Holsopph Memorial Symposium: Psychology and the Tranquilizing Drugs, read at the Annual Convention of the American Psychological Association, 1956. 9. Pollack, B.: Preliminary Report on 500 Patients Treated with Thorazine at Rochester State Hospital , Psychiat. Quart. 29:439-456, 1955. 10. Shatin, L.; Rockmore, L., and Funk, I. C.: Response of Psychiatric Patients to Massive Dosages of Thorazine: II. Psychological Test Performance and Comparative Drug Evaluation , Psychiat. Quart. 30:402-416, 1956. 11. Siegel, S.: Nonparametric Statistics for the Behavioral Sciences (McGraw-Hill Series in Psychology) , New York, McGraw-Hill Book Company, Inc., 1956, pp. 63-67. 12. Spence, K. W., and Taylor, J.: Anxiety and Strength of the NCS as Determiners of the Amount of Eyelid Conditioning , J. Exper. Psychol. 42:183-188, 1951. 13. Taylor, J. A., and Spence, K. W.: The Relationship of Anxiety Level to Performance in Serial Learning , J. Exper. Psychol. 44:61-64, 1952. 14. Terman, L. M., and Merrill, M. A.: Measuring Intelligence: A Guide to the Administration of the New Stanford-Binet Tests of Intelligence , Boston, Houghton Mifflin Company, 1937, pp. 258-259. 15. Thurstone, L. L.: A Factorial Study of Perception , Psychometric Monographs , Vol. 4, pp. 81-83, 1944. 16. Wechsler, D.: Measurement of Adult Intelligence , Baltimore, Williams & Wilkins Company, 1944. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1958.02340040112012
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction The favorable results that have been attributed to ataractic drugs in the treatment of chronic schizophrenic patients have led to numerous investigations to determine the psychological action of these agents. "Objective" studies designed to assess psychological effects occurring with such drug therapy have demonstrated few significant changes. "Subjective" clinical methods commonly employed are vulnerable to bias, as shown by Feldman.3 Some reported results are open to question because of faulty experimental design. As an applicable research design, the "double-blind" approach has important shortcomings, most noteworthy of which is that the investigator is seldom unaware of the drug group. Hall and Dunlap,5 using a double-blind approach, administered chlorpromazine in individually determined doses, up to 600 mg. daily, to a large number of semidisturbed schizophrenic patients and found significant improvement at the 5% level on subjective ratings by psychiatrists and a psychologist. However, agreement between raters was attained only References 1. Ammons, R. B., and Ammons, H. S.: Full Range Picture Vocabulary Test , Louisville, Ky., Psychological Test Specialists, 1948. 2. Becktoldt, H. P.: A Factorial Investigation of the Perceptual Speed Factor , Am. Psychologist 2:304-305, 1947. 3. Feldman, P. R.: The Personal Element in Psychiatric Research , Am. J. Psychiat. 113:52-54, 1956. 4. Finkelstein, M.; Gerboth, R., and Westerhold, R.: Standardization of a Short Form of the Wechsler Vocabulary Subtest , J. Clin. Psychol. 8:133-135, 1952.Crossref 5. Hall, R. A., and Dunlap, D. J.: A Study of Chlorpromazine: Methodology and Results with Semi-Disturbed Schizophrenics , J. Nerv. & Ment. Dis. 122:301-314, 1955. 6. Kinross-Wright, V.: Chlorpromazine Treatment of Mental Disorders , Am. J. Psychiat. 111: 907-912, 1955. 7. O'Connor, J.: Born That Way , Human Relation Series 7, Baltimore, Williams & Wilkins Company, 1928, pp. 225-310. 8. Pearl, D.: James Quinter Holsopph Memorial Symposium: Psychology and the Tranquilizing Drugs, read at the Annual Convention of the American Psychological Association, 1956. 9. Pollack, B.: Preliminary Report on 500 Patients Treated with Thorazine at Rochester State Hospital , Psychiat. Quart. 29:439-456, 1955. 10. Shatin, L.; Rockmore, L., and Funk, I. C.: Response of Psychiatric Patients to Massive Dosages of Thorazine: II. Psychological Test Performance and Comparative Drug Evaluation , Psychiat. Quart. 30:402-416, 1956. 11. Siegel, S.: Nonparametric Statistics for the Behavioral Sciences (McGraw-Hill Series in Psychology) , New York, McGraw-Hill Book Company, Inc., 1956, pp. 63-67. 12. Spence, K. W., and Taylor, J.: Anxiety and Strength of the NCS as Determiners of the Amount of Eyelid Conditioning , J. Exper. Psychol. 42:183-188, 1951. 13. Taylor, J. A., and Spence, K. W.: The Relationship of Anxiety Level to Performance in Serial Learning , J. Exper. Psychol. 44:61-64, 1952. 14. Terman, L. M., and Merrill, M. A.: Measuring Intelligence: A Guide to the Administration of the New Stanford-Binet Tests of Intelligence , Boston, Houghton Mifflin Company, 1937, pp. 258-259. 15. Thurstone, L. L.: A Factorial Study of Perception , Psychometric Monographs , Vol. 4, pp. 81-83, 1944. 16. Wechsler, D.: Measurement of Adult Intelligence , Baltimore, Williams & Wilkins Company, 1944.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Apr 1, 1958

References