Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Chloramphenicol Penetration Into Eyes

Chloramphenicol Penetration Into Eyes Abstract To the Editor.—A recent article in the Archives compared various routes of chloramphenicol administration to the aqueous humor concentrations in rabbits.1 The highest values (20 to 40 mg/liter) were found with 1% and 2% ointments. A comparison was made between these observations and those in the literature. One frequently cited report concerned our comparison of chloramphenicol penetration into eyes from different liquid vehicles.2 The technique that was used was a single, 0.05-ml drop administration followed by a wash of the external ocular surfaces with two 30-second rinses with 0.5 ml of distilled water. This procedure served to remove all surface drug, which afforded a comparison of the efficacy of the vehicle in surface drugretention capacity. However, George and Hanna, on at least three occasions, referred to the corneal bathing as a technique for drug administration rather than for drug removal. The argument used by George and References 1. George FJ, Hanna C: Ocular penetration of chloramphenicol: Effects of route of administration . Arch Ophthalmol 95:879-882, 1977.Crossref 2. Green K, MacKeen DL: Chloramphenicol retention on, and penetration into, the rabbit eye . Invest Ophthalmol 15:220-222, 1976. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Chloramphenicol Penetration Into Eyes

Archives of Ophthalmology , Volume 95 (9) – Sep 1, 1977

Chloramphenicol Penetration Into Eyes

Abstract

Abstract To the Editor.—A recent article in the Archives compared various routes of chloramphenicol administration to the aqueous humor concentrations in rabbits.1 The highest values (20 to 40 mg/liter) were found with 1% and 2% ointments. A comparison was made between these observations and those in the literature. One frequently cited report concerned our comparison of chloramphenicol penetration into eyes from different liquid vehicles.2 The technique that was used was a single,...
Loading next page...
 
/lp/american-medical-association/chloramphenicol-penetration-into-eyes-I0UYUOOxTK
Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1977.04450090172019
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.—A recent article in the Archives compared various routes of chloramphenicol administration to the aqueous humor concentrations in rabbits.1 The highest values (20 to 40 mg/liter) were found with 1% and 2% ointments. A comparison was made between these observations and those in the literature. One frequently cited report concerned our comparison of chloramphenicol penetration into eyes from different liquid vehicles.2 The technique that was used was a single, 0.05-ml drop administration followed by a wash of the external ocular surfaces with two 30-second rinses with 0.5 ml of distilled water. This procedure served to remove all surface drug, which afforded a comparison of the efficacy of the vehicle in surface drugretention capacity. However, George and Hanna, on at least three occasions, referred to the corneal bathing as a technique for drug administration rather than for drug removal. The argument used by George and References 1. George FJ, Hanna C: Ocular penetration of chloramphenicol: Effects of route of administration . Arch Ophthalmol 95:879-882, 1977.Crossref 2. Green K, MacKeen DL: Chloramphenicol retention on, and penetration into, the rabbit eye . Invest Ophthalmol 15:220-222, 1976.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1977

References