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Chlamydia Species and Mycoplasma Species in Recurrent Tonsillitis

Chlamydia Species and Mycoplasma Species in Recurrent Tonsillitis Abstract A potential role for Chlamydia species and Mycoplasma species in recurrent tonsillitis seems intriguing and has prompted Charnock et al1 to examine these possible associations with the use of varied laboratory methods. Although they suggest that such disease associations do not exist, these conclusions need to be tempered by the limitations of the microbial detection methods they describe. For Mycoplasma pneumoniae, the use of the first generation of genetic probes is hindered by the limited sensitivity of the assay (approximately 103 to 105 colony-forming units). Such limitation, for example, had detracted from the use of such an assay on throat swabs from acutely infected patients.2 Furthermore, the limitation of culture to 6 days of incubation is excessively brief. Some M pneumoniae cultures may not be positive for weeks.3 Therefore, both methods lead to a significant bias toward the detection of larger numbers of the References 1. Charnock DR, Chapman GD, Taylor RE, Wozniak A. Recurrent tonsillitis: the role for Chlamydia and Mycoplasma . Arch Otolaryngol Head Neck Surg . 1992; 118:507-508.Crossref 2. Kleemola SRM, Karjalainen JE, Raty RKH. Rapid diagnosis of Mycoplasma pneumoniae infection: clinical evaluation of a commercial probe test . J Infect Dis . 1990;162:70-75.Crossref 3. Clyde WA, Kenny GE, Schachter J, Drew WL. Laboratory Diagnosis of Chlamydial and Mycoplasmal Infections . Washington, DC: American Society for Microbiology; 1984. Cumitech 19. 4. Schachter J. Chlamydiae . In: Balows A, Hausler WJ, Herrmann KL, Isenberg HD, Shadomy HJ, eds. Manual of Clinical Microbiology . 5th ed. Washington, DC: American Society for Microbiology; 1991. 5. Saikku P, Ruutu P, Leinonen M, Panelius J, Tupasi TE, Grayston JT. Acute lower respiratory tract infection associated with Chlamydia TWAR antibody in Filipino children . J Infect Dis . 1988;158:1095-1097.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Chlamydia Species and Mycoplasma Species in Recurrent Tonsillitis

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Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1993.01880210137021
Publisher site
See Article on Publisher Site

Abstract

Abstract A potential role for Chlamydia species and Mycoplasma species in recurrent tonsillitis seems intriguing and has prompted Charnock et al1 to examine these possible associations with the use of varied laboratory methods. Although they suggest that such disease associations do not exist, these conclusions need to be tempered by the limitations of the microbial detection methods they describe. For Mycoplasma pneumoniae, the use of the first generation of genetic probes is hindered by the limited sensitivity of the assay (approximately 103 to 105 colony-forming units). Such limitation, for example, had detracted from the use of such an assay on throat swabs from acutely infected patients.2 Furthermore, the limitation of culture to 6 days of incubation is excessively brief. Some M pneumoniae cultures may not be positive for weeks.3 Therefore, both methods lead to a significant bias toward the detection of larger numbers of the References 1. Charnock DR, Chapman GD, Taylor RE, Wozniak A. Recurrent tonsillitis: the role for Chlamydia and Mycoplasma . Arch Otolaryngol Head Neck Surg . 1992; 118:507-508.Crossref 2. Kleemola SRM, Karjalainen JE, Raty RKH. Rapid diagnosis of Mycoplasma pneumoniae infection: clinical evaluation of a commercial probe test . J Infect Dis . 1990;162:70-75.Crossref 3. Clyde WA, Kenny GE, Schachter J, Drew WL. Laboratory Diagnosis of Chlamydial and Mycoplasmal Infections . Washington, DC: American Society for Microbiology; 1984. Cumitech 19. 4. Schachter J. Chlamydiae . In: Balows A, Hausler WJ, Herrmann KL, Isenberg HD, Shadomy HJ, eds. Manual of Clinical Microbiology . 5th ed. Washington, DC: American Society for Microbiology; 1991. 5. Saikku P, Ruutu P, Leinonen M, Panelius J, Tupasi TE, Grayston JT. Acute lower respiratory tract infection associated with Chlamydia TWAR antibody in Filipino children . J Infect Dis . 1988;158:1095-1097.Crossref

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Sep 1, 1993

References