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CHICAGO PEDIATRIC SOCIETY

CHICAGO PEDIATRIC SOCIETY D. M.D., President Craig Butler, Nov. 20, 1951 Regular Meeting, Further Studies of the Influence of Histamine on Platelet with Qualitative Activity, Reference to Its Action on the Hey- Especial the Blood of Dr. Hemophiliac. worth N. Dr. F. Hall Sanford, Richard and Dr. Stuyvesant (by invitation), Butler (by invitation). It was found clinical by and experimental studies that histamine when given intravenously or increased subcutaneously the of the blood directly qualitative disintegrative ability platelets. It has no effect on the total count until shock-like levels are platelet (qualitative action) obtained. It then causes a decrease in the number of the in blood. circulating platelets the The action qualitative be in due to an action between and may part antagonistic heparin histamine. in concentrations does not inhibit the increased Heparin high completely tendency toward in vitro of the in vivo histamine. agglutination platelets exposed to In administration the of the histamine to the hemophiliac patients, following plan has been followed : 0.1 of histamine is the first 0.2 the mg. given day, mg. second, 0.4 the mg. third, 0.8 mg. the and 1.0 the fifth If series amount fourth, mg. day. is the of longer desired, histamine not is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1953.02050070059007
Publisher site
See Article on Publisher Site

Abstract

D. M.D., President Craig Butler, Nov. 20, 1951 Regular Meeting, Further Studies of the Influence of Histamine on Platelet with Qualitative Activity, Reference to Its Action on the Hey- Especial the Blood of Dr. Hemophiliac. worth N. Dr. F. Hall Sanford, Richard and Dr. Stuyvesant (by invitation), Butler (by invitation). It was found clinical by and experimental studies that histamine when given intravenously or increased subcutaneously the of the blood directly qualitative disintegrative ability platelets. It has no effect on the total count until shock-like levels are platelet (qualitative action) obtained. It then causes a decrease in the number of the in blood. circulating platelets the The action qualitative be in due to an action between and may part antagonistic heparin histamine. in concentrations does not inhibit the increased Heparin high completely tendency toward in vitro of the in vivo histamine. agglutination platelets exposed to In administration the of the histamine to the hemophiliac patients, following plan has been followed : 0.1 of histamine is the first 0.2 the mg. given day, mg. second, 0.4 the mg. third, 0.8 mg. the and 1.0 the fifth If series amount fourth, mg. day. is the of longer desired, histamine not is

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Jan 1, 1953

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