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Chewing Nifedipine to Rapidly Treat Hypertension

Chewing Nifedipine to Rapidly Treat Hypertension Abstract • Nifedipine, a calcium channel-blocking agent, was administered buccally to 63 patients who had a diastolic BP of 120 mm Hg or higher (51 patients) or a systolic BP of 200 mm Hg or higher (46 patients). Forty-two patients responded to one dose of 10 mg of nifedipine with a drop in BP from 205.5±24.4/ 127.7±11.7 (mean systolic BP±SD/mean diastolic BP±SD) to 158.6±24.7/88.8±10 mm Hg in 39.9±13.0 minutes (mean±SD). Nineteen patients responded to two doses of 10 mg of nifedipine with a drop in BP from 212.1±27.1/128.2±17.3 to 165.4±24.5/93.8±10.7 mm Hg after 66.0±17.8 minutes. There were no side effects and no hypotension even among the 38 patients who had recently received other medications. Chewing perforated nifedipine capsules is a safe and effective method to lower BP promptly without parenteral medications. {Arch Intern Med 1984;144:2357-2359) References 1. Ellrodt G, Chew CYC, Singh BN: Therapeutic implications of slow channel blockade in cardio-circulatory disorders. Circulation 1980;62:669-679.Crossref 2. Braunwald E: Mechanisms of action of calcium channel-blocking agents. N Engl J Med 1982;307:1618-1627.Crossref 3. Klutsch VK, Schmidt P, Grosswendt J: Der Einfluss von BAY a 1040 auf die Nierenfunktion des Hypertonikers. Arzneimittel forsch 1972;22:377-380. 4. Murakami M, Murakami E, Takekoshi N, et al: Antihypertensive effect of 4(2'-nitrophenyl)-2-6-dimethyl-l,4-dihydropyridine-3,5-dicarbonic acid dimethyl ester (Nifedipine BAY a 1040): A new coronary dilator. Jpn Heart J 1972;13:128-135.Crossref 5. Kobayashi T, Ito Y, Tawara I: Clinical experiences with a new coronary active substance (BAY a 1040). Arzneimittel forsch 1972;22:380-389. 6. Aoki K, Yoshida T, Kato S, et al: Hypotensive action and increased plasma renin activity by calcium antagonist (nifedipine) in hypertensive patients. Jpn Heart J 1976;17:479-484.Crossref 7. Beer N, Gallegos I, Cohen A, et al: Efficacy of sublingual nifedipine in the acute treatment of systemic hypertension. Chest 1981;79:571-574.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Chewing Nifedipine to Rapidly Treat Hypertension

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1984.00350220073017
Publisher site
See Article on Publisher Site

Abstract

Abstract • Nifedipine, a calcium channel-blocking agent, was administered buccally to 63 patients who had a diastolic BP of 120 mm Hg or higher (51 patients) or a systolic BP of 200 mm Hg or higher (46 patients). Forty-two patients responded to one dose of 10 mg of nifedipine with a drop in BP from 205.5±24.4/ 127.7±11.7 (mean systolic BP±SD/mean diastolic BP±SD) to 158.6±24.7/88.8±10 mm Hg in 39.9±13.0 minutes (mean±SD). Nineteen patients responded to two doses of 10 mg of nifedipine with a drop in BP from 212.1±27.1/128.2±17.3 to 165.4±24.5/93.8±10.7 mm Hg after 66.0±17.8 minutes. There were no side effects and no hypotension even among the 38 patients who had recently received other medications. Chewing perforated nifedipine capsules is a safe and effective method to lower BP promptly without parenteral medications. {Arch Intern Med 1984;144:2357-2359) References 1. Ellrodt G, Chew CYC, Singh BN: Therapeutic implications of slow channel blockade in cardio-circulatory disorders. Circulation 1980;62:669-679.Crossref 2. Braunwald E: Mechanisms of action of calcium channel-blocking agents. N Engl J Med 1982;307:1618-1627.Crossref 3. Klutsch VK, Schmidt P, Grosswendt J: Der Einfluss von BAY a 1040 auf die Nierenfunktion des Hypertonikers. Arzneimittel forsch 1972;22:377-380. 4. Murakami M, Murakami E, Takekoshi N, et al: Antihypertensive effect of 4(2'-nitrophenyl)-2-6-dimethyl-l,4-dihydropyridine-3,5-dicarbonic acid dimethyl ester (Nifedipine BAY a 1040): A new coronary dilator. Jpn Heart J 1972;13:128-135.Crossref 5. Kobayashi T, Ito Y, Tawara I: Clinical experiences with a new coronary active substance (BAY a 1040). Arzneimittel forsch 1972;22:380-389. 6. Aoki K, Yoshida T, Kato S, et al: Hypotensive action and increased plasma renin activity by calcium antagonist (nifedipine) in hypertensive patients. Jpn Heart J 1976;17:479-484.Crossref 7. Beer N, Gallegos I, Cohen A, et al: Efficacy of sublingual nifedipine in the acute treatment of systemic hypertension. Chest 1981;79:571-574.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1984

References