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Chemotherapy for Lymphoma in a Patient With Common Variable Immunodeficiency: Case Report, Literature Review, and Recommendations for Chemotherapy in Immunodeficient Patients

Chemotherapy for Lymphoma in a Patient With Common Variable Immunodeficiency: Case Report,... Abstract A man with long-standing common variable hypogammaglobulinemia was treated with chemotherapy and local radiation for diffuse mixed lymphoma. He continues in complete remission 42 months after the completion of therapy. Vigorous therapy for lymphoma can be used in the face of preexistent immunodeficiency. Complete staging and appropriate combination chemotherapy or radiation therapy should be carried out for lymphomas that occur in certain immunodeficient patients. (Arch Intern Med 1982;142:90-92) References 1. Gatti RA, Good RA: Occurrence of malignancy in immunodeficiency diseases: A literature review. Cancer 1971;28:89-98.Crossref 2. Waldmann TA, Strober W, Blaese RM: Immunodeficiency disease and malignancy: Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease. Ann Intern Med 1972;77:605-628.Crossref 3. Kersey JM, Spector BD, Good RA: Primary immunodeficiency diseases and cancer: The Immunodeficiency-Cancer Registry. Int J Cancer 1973;12:333-347.Crossref 4. Spector BD, Perry GS, Kersey JM: Genetically determined immunodeficiency diseases and malignancy: Report from the Immunodeficiency-Cancer Registry. Clin Immunol Immunopathol 1978;11:12-29.Crossref 5. Faraci RP, Hoffstrand HJ, Witebsky FG, et al: Malignant lymphoma of the jejunum in a patient with Wiskott-Aldrich syndrome: Surgical treatment. Arch Surg 1975;110:218-220.Crossref 6. Pelkonen R, Sivrala M, Vuopio P: Inherited agammaglobulinemia with malabsorption and marked alterations in the gastrointestinal mucosa. Acta Med Scand 1963;173:549-555.Crossref 7. Green I, Litwin S, Adlersbey R, et al: Hypogammaglobulinemia with late development of lymphosarcoma. Arch Intern Med 1966;118:592-602.Crossref 8. Freeman AI, Finks LF, Cohen MM: Lymphosarcoma in siblings, associated with cytogenetic abnormalities, immunodeficiency, and abnormal erythropoiesis. J Pediatr 1970;77:996-1003.Crossref 9. Brouet JC, Clauvel JP, Jarriau P, et al: Deficit immunitaire avec nanisme complique d'un reticulosarcome chez deux soeurs. Arch Fr Pediatr 1973;30:655-661. 10. Broder S, Muchmore AV, Strober W, et al: Resolution of massive protein losing enteropathy following anti-inflammatory therapy, abstracted. Clin Res 1977;25:308. 11. Potolsky AI, Heath CW, Buckley CE, et al: Lymphoreticular malignancies and immunologic abnormalities in a sibship. Am J Med 1971;50:42-48.Crossref 12. Sheil AGR: Cancer in renal allograft recipients in Australia and New Zealand. Transplant Proc 1977;9:1133-1136. 13. Taylor A, Harnden D, Arlett C, et al: Ataxia-telangiectasia: A human mutation with abnormal radiation sensitivity. Nature 1975;258:427-429.Crossref 14. Paterson MC, Smith BP, Lohman PHM, et al: Defective excision repair of x-ray-damaged DNA in human (ataxia-telangiectasia) fibroblasts. Nature 1976;260:444-447.Crossref 15. Anderson TA, Bender RA, Fisher RI, et al: Combination chemotherapy in non-Hodgkin's lymphoma: Results of long-term follow-up. Cancer Treat Rep 1977;61:1057-1066. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Chemotherapy for Lymphoma in a Patient With Common Variable Immunodeficiency: Case Report, Literature Review, and Recommendations for Chemotherapy in Immunodeficient Patients

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340140092017
Publisher site
See Article on Publisher Site

Abstract

Abstract A man with long-standing common variable hypogammaglobulinemia was treated with chemotherapy and local radiation for diffuse mixed lymphoma. He continues in complete remission 42 months after the completion of therapy. Vigorous therapy for lymphoma can be used in the face of preexistent immunodeficiency. Complete staging and appropriate combination chemotherapy or radiation therapy should be carried out for lymphomas that occur in certain immunodeficient patients. (Arch Intern Med 1982;142:90-92) References 1. Gatti RA, Good RA: Occurrence of malignancy in immunodeficiency diseases: A literature review. Cancer 1971;28:89-98.Crossref 2. Waldmann TA, Strober W, Blaese RM: Immunodeficiency disease and malignancy: Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease. Ann Intern Med 1972;77:605-628.Crossref 3. Kersey JM, Spector BD, Good RA: Primary immunodeficiency diseases and cancer: The Immunodeficiency-Cancer Registry. Int J Cancer 1973;12:333-347.Crossref 4. Spector BD, Perry GS, Kersey JM: Genetically determined immunodeficiency diseases and malignancy: Report from the Immunodeficiency-Cancer Registry. Clin Immunol Immunopathol 1978;11:12-29.Crossref 5. Faraci RP, Hoffstrand HJ, Witebsky FG, et al: Malignant lymphoma of the jejunum in a patient with Wiskott-Aldrich syndrome: Surgical treatment. Arch Surg 1975;110:218-220.Crossref 6. Pelkonen R, Sivrala M, Vuopio P: Inherited agammaglobulinemia with malabsorption and marked alterations in the gastrointestinal mucosa. Acta Med Scand 1963;173:549-555.Crossref 7. Green I, Litwin S, Adlersbey R, et al: Hypogammaglobulinemia with late development of lymphosarcoma. Arch Intern Med 1966;118:592-602.Crossref 8. Freeman AI, Finks LF, Cohen MM: Lymphosarcoma in siblings, associated with cytogenetic abnormalities, immunodeficiency, and abnormal erythropoiesis. J Pediatr 1970;77:996-1003.Crossref 9. Brouet JC, Clauvel JP, Jarriau P, et al: Deficit immunitaire avec nanisme complique d'un reticulosarcome chez deux soeurs. Arch Fr Pediatr 1973;30:655-661. 10. Broder S, Muchmore AV, Strober W, et al: Resolution of massive protein losing enteropathy following anti-inflammatory therapy, abstracted. Clin Res 1977;25:308. 11. Potolsky AI, Heath CW, Buckley CE, et al: Lymphoreticular malignancies and immunologic abnormalities in a sibship. Am J Med 1971;50:42-48.Crossref 12. Sheil AGR: Cancer in renal allograft recipients in Australia and New Zealand. Transplant Proc 1977;9:1133-1136. 13. Taylor A, Harnden D, Arlett C, et al: Ataxia-telangiectasia: A human mutation with abnormal radiation sensitivity. Nature 1975;258:427-429.Crossref 14. Paterson MC, Smith BP, Lohman PHM, et al: Defective excision repair of x-ray-damaged DNA in human (ataxia-telangiectasia) fibroblasts. Nature 1976;260:444-447.Crossref 15. Anderson TA, Bender RA, Fisher RI, et al: Combination chemotherapy in non-Hodgkin's lymphoma: Results of long-term follow-up. Cancer Treat Rep 1977;61:1057-1066.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1982

References