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Chemotherapy, BCG, and Serum From Tumor-Bearing Mice: Comparative Effects on Growth and Spread of Mouse Lewis Lung Cancer

Chemotherapy, BCG, and Serum From Tumor-Bearing Mice: Comparative Effects on Growth and Spread of... Abstract In 101 mice, Lewis lung tumor (25 mg apiece) was implanted subcutaneously in the right hind limb and the mice separated into various groups and protocols to test treatment with immunotherapeutic and chemotherapeutic agents. In those treated intralesionally with BCG, the growth of primary tumor was retarded (P ≤.05). Tumor growth in animals treated with systemic BCG and serum from tumor-bearing mice was not different from controls. In 14 of 20 mice treated with chemotherapy (semustine and cyclophosphamide), there was no primary or metastatic growth (P ≤.01). The observations show that this sort of systemic immunotherapy had no effect on mouse Lewis lung tumor, that intralesionally there was a retarding effect of BCG (although it did not influence metastases), and that this protocol of chemotherapy was strikingly effective. References 1. Karrer K, Humphreys SR: Continuous and limited courses of cyclophosphamide (NSC-26271) in mice with pulmonary metastasis after surgery . Cancer Chemother Rep 51:439-449, 1967. 2. Mayo JG, Laster WR, Andrews CM, et al: Success and failure in the treatment of solid tumors: III. "Cure" of metastatic Lewis lung carcinoma with methyl CCNU and surgery-chemotherapy . Cancer Chemother Rep 56:183-195, 1972. 3. Old LJ, Benacerraf B, Clarke DA, et al: The role of the reticulonendothelial system in the host reaction to neoplasia . Cancer Res 21:1281-1300, 1961. 4. Proctor JW, Rudenstam CM, Alexander P: A factor preventing the development of lung metastases in rats with sarcomas . Nature 242:29-31, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Chemotherapy, BCG, and Serum From Tumor-Bearing Mice: Comparative Effects on Growth and Spread of Mouse Lewis Lung Cancer

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1975.01360140045009
Publisher site
See Article on Publisher Site

Abstract

Abstract In 101 mice, Lewis lung tumor (25 mg apiece) was implanted subcutaneously in the right hind limb and the mice separated into various groups and protocols to test treatment with immunotherapeutic and chemotherapeutic agents. In those treated intralesionally with BCG, the growth of primary tumor was retarded (P ≤.05). Tumor growth in animals treated with systemic BCG and serum from tumor-bearing mice was not different from controls. In 14 of 20 mice treated with chemotherapy (semustine and cyclophosphamide), there was no primary or metastatic growth (P ≤.01). The observations show that this sort of systemic immunotherapy had no effect on mouse Lewis lung tumor, that intralesionally there was a retarding effect of BCG (although it did not influence metastases), and that this protocol of chemotherapy was strikingly effective. References 1. Karrer K, Humphreys SR: Continuous and limited courses of cyclophosphamide (NSC-26271) in mice with pulmonary metastasis after surgery . Cancer Chemother Rep 51:439-449, 1967. 2. Mayo JG, Laster WR, Andrews CM, et al: Success and failure in the treatment of solid tumors: III. "Cure" of metastatic Lewis lung carcinoma with methyl CCNU and surgery-chemotherapy . Cancer Chemother Rep 56:183-195, 1972. 3. Old LJ, Benacerraf B, Clarke DA, et al: The role of the reticulonendothelial system in the host reaction to neoplasia . Cancer Res 21:1281-1300, 1961. 4. Proctor JW, Rudenstam CM, Alexander P: A factor preventing the development of lung metastases in rats with sarcomas . Nature 242:29-31, 1973.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Aug 1, 1975

References