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Chemotherapeutic Immunosuppression of the Corneal Graft Reaction: III. Topical Azathioprine

Chemotherapeutic Immunosuppression of the Corneal Graft Reaction: III. Topical Azathioprine Abstract Parenteral administration of the purine antimetabolite azathioprine has been shown to be capable of suppressing experimental corneal graft reactions.1,2 However, the potential toxicity of this agent has thus far prevented its routine use in healthy human subjects with scarred, vascularized corneas, who require penetrating keratoplasty for visual restoration. Thus, our recent investigations have focused on methods of circumventing the toxic side effects associated with systemic azathioprine therapy while making use of its immunosuppressive properties. An earlier paper of this series reported the success of a combined therapeutic regimen in achieving this purpose. This regimen consisted of the initial use of parenteral azathioprine for ten days; thereafter, immunosuppression was maintained by topical corticosteriods.3 This report deals with another attempt to avoid the toxicity associated with systemic azathioprine administration. In these experiments, topical azathioprine was used in two concentrations in a fat-soluble as well as in a water-soluble ointment base. References 1. Part I, "Systemic Antimetabolites" may be found in the June 1966 issue of the Archives, pp 826-835, and part II, "Combined Systemic Antimetabolite and Topical Corticosteroid Therapy," in the September 1966 issue, pp 338-344. 2. Leibowitz, H.M., and Elliott, J.H.: Chemotherapeutic Immunosuppression of the Corneal Graft Reaction: I. Systemic Antimetabolites , Arch Ophthal 75:826-835 ( (June) ) 1966.Crossref 3. Polack, F.M.: Inhibition of Immune Corneal Graft Rejection by Azathioprine (Imuran) , Arch Ophthal 74:683-689 ( (Nov) ) 1965.Crossref 4. Leibowitz, H.M., and Elliott, J.H.: Chemotherapeutic Immunosuppression of the Corneal Graft Reaction: II. Combined Systemic Antimetabolite and Topical Corticosteroid Therapy , Arch Ophthal 76: 338-344 ( (Sept) ) 1966.Crossref 5. Siegel, S.: Nonparametric Statistics for the Behavioral Sciences , New York: McGraw-Hill Book Co., 1956, pp 116-123. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Chemotherapeutic Immunosuppression of the Corneal Graft Reaction: III. Topical Azathioprine

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1966.03850010711016
Publisher site
See Article on Publisher Site

Abstract

Abstract Parenteral administration of the purine antimetabolite azathioprine has been shown to be capable of suppressing experimental corneal graft reactions.1,2 However, the potential toxicity of this agent has thus far prevented its routine use in healthy human subjects with scarred, vascularized corneas, who require penetrating keratoplasty for visual restoration. Thus, our recent investigations have focused on methods of circumventing the toxic side effects associated with systemic azathioprine therapy while making use of its immunosuppressive properties. An earlier paper of this series reported the success of a combined therapeutic regimen in achieving this purpose. This regimen consisted of the initial use of parenteral azathioprine for ten days; thereafter, immunosuppression was maintained by topical corticosteriods.3 This report deals with another attempt to avoid the toxicity associated with systemic azathioprine administration. In these experiments, topical azathioprine was used in two concentrations in a fat-soluble as well as in a water-soluble ointment base. References 1. Part I, "Systemic Antimetabolites" may be found in the June 1966 issue of the Archives, pp 826-835, and part II, "Combined Systemic Antimetabolite and Topical Corticosteroid Therapy," in the September 1966 issue, pp 338-344. 2. Leibowitz, H.M., and Elliott, J.H.: Chemotherapeutic Immunosuppression of the Corneal Graft Reaction: I. Systemic Antimetabolites , Arch Ophthal 75:826-835 ( (June) ) 1966.Crossref 3. Polack, F.M.: Inhibition of Immune Corneal Graft Rejection by Azathioprine (Imuran) , Arch Ophthal 74:683-689 ( (Nov) ) 1965.Crossref 4. Leibowitz, H.M., and Elliott, J.H.: Chemotherapeutic Immunosuppression of the Corneal Graft Reaction: II. Combined Systemic Antimetabolite and Topical Corticosteroid Therapy , Arch Ophthal 76: 338-344 ( (Sept) ) 1966.Crossref 5. Siegel, S.: Nonparametric Statistics for the Behavioral Sciences , New York: McGraw-Hill Book Co., 1956, pp 116-123.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1966

References

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