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Chemosurgery for Skin Cancer: Fixed Tissue and Fresh Tissue Techniques

Chemosurgery for Skin Cancer: Fixed Tissue and Fresh Tissue Techniques Abstract • Complete microscopical control of the excision of cancer of the skin is achieved by removing tissues layer by layer and examining the undersurface of each layer by means of frozen sections. If the cancer is extensive and complicated or if it is of a type readily spread over an excisional surface, the tissues are fixed in situ with zinc chloride prior to excision (chemosurgery, fixed tissue technique). If the cancer is not too extensive or complicated, the tissues are excised in the fresh, unfixed state (chemosurgery, fresh tissue technique). Both techniques are highly reliable; for example, in two consecutive series of basal cell carcinomas treated chemosurgically, the five-year rate of cure was 99.3% for the 9,351 lesions removed by the fixed tissue technique and 97% for the 127 lesions removed by the fresh tissue technique. (Arch Dermatol 112:211-215, 1976) References 1. Mohs FE: Chemosurgery in Cancer, Gangrene and Infections . Springfield, Ill, Charles C Thomas Publisher, 1956. 2. Mohs FE, Guyer MF: Pre-excisional fixation of tissues in the treatment of cancer in rats . Cancer Res 1:49-51, 1941. 3. Mohs FE: Chemosurgery: A microscopically controlled method of cancer excision . Arch Surg 42:279-295, 1941.Crossref 4. Mohs FE: The chemosurgical method for the microscopically controlled excision of external cancer with reference to eyelid . Trans Am Acad Ophthalmol Otolaryngol 62:355-356, 1958. 5. Mohs FE: Chemosurgery for facial neoplasms . Arch Otolaryngol 95:62-67, 1972.Crossref 6. Tromovitch TA, Stegeman SJ: Microscopically controlled excision of skin tumors: Chemosurgery (Mohs): Fresh tissue technique . Arch Dermatol 110:231-232, 1974.Crossref 7. Mohs FE: Chemosurgical treatment of melanoma: A microscopically controlled method of excision . Arch Dermatol Syphilol 62:269-279, 1950.Crossref 8. Mohs FE: Prevention and treatment of skin cancer . Wis Med J 73:85-92, 1974. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Chemosurgery for Skin Cancer: Fixed Tissue and Fresh Tissue Techniques

Mohs, Frederic E.
Archives of Dermatology , Volume 112 (2) – Feb 1, 1976
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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630260033010
Publisher site
See Article on Publisher Site

Abstract

Abstract • Complete microscopical control of the excision of cancer of the skin is achieved by removing tissues layer by layer and examining the undersurface of each layer by means of frozen sections. If the cancer is extensive and complicated or if it is of a type readily spread over an excisional surface, the tissues are fixed in situ with zinc chloride prior to excision (chemosurgery, fixed tissue technique). If the cancer is not too extensive or complicated, the tissues are excised in the fresh, unfixed state (chemosurgery, fresh tissue technique). Both techniques are highly reliable; for example, in two consecutive series of basal cell carcinomas treated chemosurgically, the five-year rate of cure was 99.3% for the 9,351 lesions removed by the fixed tissue technique and 97% for the 127 lesions removed by the fresh tissue technique. (Arch Dermatol 112:211-215, 1976) References 1. Mohs FE: Chemosurgery in Cancer, Gangrene and Infections . Springfield, Ill, Charles C Thomas Publisher, 1956. 2. Mohs FE, Guyer MF: Pre-excisional fixation of tissues in the treatment of cancer in rats . Cancer Res 1:49-51, 1941. 3. Mohs FE: Chemosurgery: A microscopically controlled method of cancer excision . Arch Surg 42:279-295, 1941.Crossref 4. Mohs FE: The chemosurgical method for the microscopically controlled excision of external cancer with reference to eyelid . Trans Am Acad Ophthalmol Otolaryngol 62:355-356, 1958. 5. Mohs FE: Chemosurgery for facial neoplasms . Arch Otolaryngol 95:62-67, 1972.Crossref 6. Tromovitch TA, Stegeman SJ: Microscopically controlled excision of skin tumors: Chemosurgery (Mohs): Fresh tissue technique . Arch Dermatol 110:231-232, 1974.Crossref 7. Mohs FE: Chemosurgical treatment of melanoma: A microscopically controlled method of excision . Arch Dermatol Syphilol 62:269-279, 1950.Crossref 8. Mohs FE: Prevention and treatment of skin cancer . Wis Med J 73:85-92, 1974.

Journal

Archives of Dermatology – American Medical Association

Published: Feb 1, 1976

References

  • Chemosurgery in Cancer, Gangrene and Infections
    Mohs FE
  • Pre-excisional fixation of tissues in the treatment of cancer in rats
    Mohs FE, Guyer MF
  • Chemosurgery: A microscopically controlled method of cancer excision
    Mohs FE
  • The chemosurgical method for the microscopically controlled excision of external cancer with reference to eyelid
    Mohs FE
  • Chemosurgery for facial neoplasms
    Mohs FE
  • Microscopically controlled excision of skin tumors: Chemosurgery (Mohs): Fresh tissue technique
    Tromovitch TA, Stegeman SJ
  • Chemosurgical treatment of melanoma: A microscopically controlled method of excision
    Mohs FE
  • Prevention and treatment of skin cancer
    Mohs FE