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Chemodectoma of the Mediastinum

Chemodectoma of the Mediastinum Abstract In 1950, the term "chemodectoma" was proposed as the generic name for tumors arising from the nonchromaffin neuroepithelial cells located in the adventitia of blood vessels derived from the branchial arches. The ganglia of the glossopharyngeal and vagus nerves are also sites of the neoplasms.1-3 These cell aggregates have neither endocrine nor motor function. They have the propensity for perceiving chemical changes in the circulatory system and thus act as a sensory component in a reflex arc which allows transmission of impulses centrally over afferent parasympathetic nerve fibers. In this way, blood flow and respiratory rate may be controlled.4,5 Although these neuroepithelial cells are found in many sites, by far the most common location of neoplasm is the carotid body at the main carotid bifurcation. This entity was first described by Marchand in 1891.6 Chemodectomas arising from aortic bodies situated in the mediastinum are rarely seen.7 References 1. Boyd, J. D.: "The Development of the Human Carotid Body," in Contributions to Embryology , publication No. 479, Washington, DC: Carnegie Institute, 1937. 2. Nonidez, J. F.: The Aortic (Depressor) Nerve and Its Associated Epitheliod Body, the Glomus Aorticum , Amer J Anat 57:259-293, 1935.Crossref 3. Smetana, H. F., and Scott, W. R., Jr.: Malignant Tumors of Non-Chromaffin Paraganglia , Milit Surg 109:330-341, 1951. 4. Schmidt, C. F., and Comroe, J. H., Jr.: Functions of Carotid and Aortic Bodies , Physiol Rev 20:115-157, 1940. 5. Dripps, R. D., Jr., and Comroe, J. H.: The Clinical Significance of the Cartoid and Aortic Bodies , Amer J Med Sci 208:681-694, 1944.Crossref 6. Marchand, F.: Beitrage sur Kenntniss der normalen und pathologischen Anatomie der Glandula Carotica und der Nebennieren , Virchow Arch Path Anat 1:535-581, 1891. 7. Lottes, R.: Non-Chromaffin Paraganglioma of Ganglion Nodosum, Carotid Body and Aortic Arch Bodies , Cancer 3:667-694, 1950.Crossref 8. LeCompte, P. M.: Tumors of the Carotid Body and Related Structures (Chemoreceptor System), sect IV, fasc 16, Atlas of Tumor Pathology, US Armed Forces Institute of Pathology, 1951. 9. Nathan, M. H.; Collins, V. P.; and Adams, R. A.: Differentiation of Benign and Malignant Pulmonary Nodules by Growth Rate , Radiology 79: 221-232, 1962.Crossref 10. Spratt, J. S., Jr.; Roper, C. L.; and Spjut, H. J.: The Frequency Distribution of the Rates of Growth and the Estimated Duration of Primary Pulmonary Carcinomas , Cancer 16:687-693, 1963.Crossref 11. Spratt, J. S., Jr., and Spratt, T. L.: The Rates of Growth of Pulmonary Metastases and Host Survival, Ann Surg, to be published. 12. Monro, R. S.: The Morphology of the Branchial Glomera and Their Tumours: With a Report of a Case of Aortico-Pulmonary Glomus Tumour , Brit J Surg 38:105-109, 1950.Crossref 13. McDonald, O. G.; Aufderheide, A. C.; and Fuller, J.: Chemodectoma (Non-Chromaffin Paraganglioma) of the Mediastinum , Ann Surg 140: 254-256, 1954.Crossref 14. Mendelow, H., and Slobodkin, M.: Aortic-Body Tumor (Chemodectoma) of the Mediastinum: Report of a Case and Review of the Literature , Cancer 10:1008-1014, 1957.Crossref 15. Madden, T. J.: Mediastinal Chemodectoma , Ann Surg 148:943-950, 1958.Crossref 16. Tama, L.; Ellis, F. J., Jr.; Hodgson, C. H.; and Dockerty, M. B.: Chemodectoma of the Mediastinum: Report on a Patient With Superior Vena Caval Obstruction Treated by a Shunt from the Right Innominate Vein to the Right Atrium , J Thorac Cardiov Surg 43:585-594, 1962. 17. Duncan, D. K., and McDonald, J. R.: Chemodectoma ("Non-Chromaffin Paraganglioma") of the Mediastinum: Report of Two Cases , Amer J Clin Path 21:515-520, 1951. 18. Davies, J. R., and Randall, K. J.: Benign Aortic-Body Tumour , J Path Bact 68:247-250, 1954.Crossref 19. MacDonald, R. A.: A Carotid-Body-Like Tumor on the Left Subclavian Artery , AMA Arch Path 62:107-111, 1956. 20. Taylor, M. J., and Evans, P. V.: Non-Chromaffin Paraganglioma (Chemodectoma) of Mediastinum: Report of Case and Review of Literature , AMA Arch Surg 77:242-247, 1958.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1963.01310180019005
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1950, the term "chemodectoma" was proposed as the generic name for tumors arising from the nonchromaffin neuroepithelial cells located in the adventitia of blood vessels derived from the branchial arches. The ganglia of the glossopharyngeal and vagus nerves are also sites of the neoplasms.1-3 These cell aggregates have neither endocrine nor motor function. They have the propensity for perceiving chemical changes in the circulatory system and thus act as a sensory component in a reflex arc which allows transmission of impulses centrally over afferent parasympathetic nerve fibers. In this way, blood flow and respiratory rate may be controlled.4,5 Although these neuroepithelial cells are found in many sites, by far the most common location of neoplasm is the carotid body at the main carotid bifurcation. This entity was first described by Marchand in 1891.6 Chemodectomas arising from aortic bodies situated in the mediastinum are rarely seen.7 References 1. Boyd, J. D.: "The Development of the Human Carotid Body," in Contributions to Embryology , publication No. 479, Washington, DC: Carnegie Institute, 1937. 2. Nonidez, J. F.: The Aortic (Depressor) Nerve and Its Associated Epitheliod Body, the Glomus Aorticum , Amer J Anat 57:259-293, 1935.Crossref 3. Smetana, H. F., and Scott, W. R., Jr.: Malignant Tumors of Non-Chromaffin Paraganglia , Milit Surg 109:330-341, 1951. 4. Schmidt, C. F., and Comroe, J. H., Jr.: Functions of Carotid and Aortic Bodies , Physiol Rev 20:115-157, 1940. 5. Dripps, R. D., Jr., and Comroe, J. H.: The Clinical Significance of the Cartoid and Aortic Bodies , Amer J Med Sci 208:681-694, 1944.Crossref 6. Marchand, F.: Beitrage sur Kenntniss der normalen und pathologischen Anatomie der Glandula Carotica und der Nebennieren , Virchow Arch Path Anat 1:535-581, 1891. 7. Lottes, R.: Non-Chromaffin Paraganglioma of Ganglion Nodosum, Carotid Body and Aortic Arch Bodies , Cancer 3:667-694, 1950.Crossref 8. LeCompte, P. M.: Tumors of the Carotid Body and Related Structures (Chemoreceptor System), sect IV, fasc 16, Atlas of Tumor Pathology, US Armed Forces Institute of Pathology, 1951. 9. Nathan, M. H.; Collins, V. P.; and Adams, R. A.: Differentiation of Benign and Malignant Pulmonary Nodules by Growth Rate , Radiology 79: 221-232, 1962.Crossref 10. Spratt, J. S., Jr.; Roper, C. L.; and Spjut, H. J.: The Frequency Distribution of the Rates of Growth and the Estimated Duration of Primary Pulmonary Carcinomas , Cancer 16:687-693, 1963.Crossref 11. Spratt, J. S., Jr., and Spratt, T. L.: The Rates of Growth of Pulmonary Metastases and Host Survival, Ann Surg, to be published. 12. Monro, R. S.: The Morphology of the Branchial Glomera and Their Tumours: With a Report of a Case of Aortico-Pulmonary Glomus Tumour , Brit J Surg 38:105-109, 1950.Crossref 13. McDonald, O. G.; Aufderheide, A. C.; and Fuller, J.: Chemodectoma (Non-Chromaffin Paraganglioma) of the Mediastinum , Ann Surg 140: 254-256, 1954.Crossref 14. Mendelow, H., and Slobodkin, M.: Aortic-Body Tumor (Chemodectoma) of the Mediastinum: Report of a Case and Review of the Literature , Cancer 10:1008-1014, 1957.Crossref 15. Madden, T. J.: Mediastinal Chemodectoma , Ann Surg 148:943-950, 1958.Crossref 16. Tama, L.; Ellis, F. J., Jr.; Hodgson, C. H.; and Dockerty, M. B.: Chemodectoma of the Mediastinum: Report on a Patient With Superior Vena Caval Obstruction Treated by a Shunt from the Right Innominate Vein to the Right Atrium , J Thorac Cardiov Surg 43:585-594, 1962. 17. Duncan, D. K., and McDonald, J. R.: Chemodectoma ("Non-Chromaffin Paraganglioma") of the Mediastinum: Report of Two Cases , Amer J Clin Path 21:515-520, 1951. 18. Davies, J. R., and Randall, K. J.: Benign Aortic-Body Tumour , J Path Bact 68:247-250, 1954.Crossref 19. MacDonald, R. A.: A Carotid-Body-Like Tumor on the Left Subclavian Artery , AMA Arch Path 62:107-111, 1956. 20. Taylor, M. J., and Evans, P. V.: Non-Chromaffin Paraganglioma (Chemodectoma) of Mediastinum: Report of Case and Review of Literature , AMA Arch Surg 77:242-247, 1958.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Dec 1, 1963

References

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