Key PointsQuestionHow do the characteristics and outcomes of children and adolescents with multisystem inflammatory syndrome in children (MIS-C) compare with severe coronavirus disease 2019 (COVID-19)? FindingsIn this case series that included 539 patients with MIS-C and 577 patients with severe COVID-19, patients with MIS-C were more likely than those with severe COVID-19 to be 6 to 12 years old, be non-Hispanic Black, and have severe cardiovascular or mucocutaneous involvement and more extreme inflammation. MeaningThe study findings suggest patterns of clinical presentation and organ involvement that distinguish between patients with MIS-C and severe acute COVID-19.
JAMA – American Medical Association
Published: Mar 16, 2021