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Changes in the Risk of Death After HIV Seroconversion Compared With Mortality in the General Population

Changes in the Risk of Death After HIV Seroconversion Compared With Mortality in the General... ORIGINAL CONTRIBUTION Changes in the Risk of Death After HIV Seroconversion Compared With Mortality in the General Population Krishnan Bhaskaran, MSc Context Mortality among human immunodeficiency virus (HIV)–infected individu- Osamah Hamouda, MD als has decreased dramatically in countries with good access to treatment and may now be close to mortality in the general uninfected population. Mette Sannes, MLabTech Objective To evaluate changes in the mortality gap between HIV-infected individu- Faroudy Boufassa, MD als and the general uninfected population. Anne M. Johnson, MD Design, Setting, and Population Mortality following HIV seroconversion in a large Paul C. Lambert, PhD multinational collaboration of HIV seroconverter cohorts (CASCADE) was compared with expected mortality, calculated by applying general population death rates matched Kholoud Porter, PhD on demographic factors. A Poisson-based model adjusted for duration of infection was for the CASCADE Collaboration constructed to assess changes over calendar time in the excess mortality among HIV- infected individuals. Data pooled in September 2007 were analyzed in March 2008, covering years at risk 1981-2006. NUMBER OF STUDIES HAVE RE- ported the dramatic de- Main Outcome Measure Excess mortality among HIV-infected individuals com- creases in mortality among pared with that of the general uninfected population. Aindividuals infected with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Changes in the Risk of Death After HIV Seroconversion Compared With Mortality in the General Population

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Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.300.1.51
pmid
18594040
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Changes in the Risk of Death After HIV Seroconversion Compared With Mortality in the General Population Krishnan Bhaskaran, MSc Context Mortality among human immunodeficiency virus (HIV)–infected individu- Osamah Hamouda, MD als has decreased dramatically in countries with good access to treatment and may now be close to mortality in the general uninfected population. Mette Sannes, MLabTech Objective To evaluate changes in the mortality gap between HIV-infected individu- Faroudy Boufassa, MD als and the general uninfected population. Anne M. Johnson, MD Design, Setting, and Population Mortality following HIV seroconversion in a large Paul C. Lambert, PhD multinational collaboration of HIV seroconverter cohorts (CASCADE) was compared with expected mortality, calculated by applying general population death rates matched Kholoud Porter, PhD on demographic factors. A Poisson-based model adjusted for duration of infection was for the CASCADE Collaboration constructed to assess changes over calendar time in the excess mortality among HIV- infected individuals. Data pooled in September 2007 were analyzed in March 2008, covering years at risk 1981-2006. NUMBER OF STUDIES HAVE RE- ported the dramatic de- Main Outcome Measure Excess mortality among HIV-infected individuals com- creases in mortality among pared with that of the general uninfected population. Aindividuals infected with

Journal

JAMAAmerican Medical Association

Published: Jul 2, 2008

References