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CHANGES IN THE MORPHOLOGY AND FUNCTION OF THE BONE MARROW AFTER SPLENECTOMY

CHANGES IN THE MORPHOLOGY AND FUNCTION OF THE BONE MARROW AFTER SPLENECTOMY Abstract INTRODUCTION In this series of investigations on the bone marrow I have had a two-fold purpose: first, to devise a new method of studying marrow that would secure a connected picture of changes in the marrow, and second, to observe the function of the marrow after the removal of the spleen. The need of this investigation was suggested to me by my findings in a previous study1 of the blood changes after removal of the spleen for kala-azar.Hitherto most observations on the function of the marrow have been limited to single isolated specimens, usually secured at necropsy or by etherizing laboratory animals. A single specimen of bone marrow gives insufficient evidence. An adequate conception of the behavior of the marrow can be secured only by frequent observations (on the same person or laboratory animal) at regular intervals and over a period sufficiently long to afford a connected record References 1. Johnstone, E. M.: A Study of Blood Changes in Kala-Azar After Splenectomy , China M. J. 32:505-513, 1918. 2. Pearce, R. M.; Krumbhaar, F. B., and Frazier, C. H.: The Spleen and Anemia, Experimental and Clinical Studies , Philadelphia, J. B. Lippincott, 1918. 3. Bunting, C. H.: Experimental Anemias in the Rabbit , J. Exper. Med. 8:625-646, 1906.Crossref 4. Gruner, O. C.: The Biology of the Blood Cells, with a Glossary of Hematological Terms . Bristol, J. Wright and Sons, 1913. 5. Gulland, G. E., and Goodall, A.: The Blood, a Guide to Its Examination and to the Diagnosis and Treatment of Its Diseases , Edinburgh, W. Green and Sons, 1914, p. 96 and p. 110. 6. Warthin, A. S.: The Changes Produced in the Hemolymph Glands of the Sheep and Goat by Splenectomy, Hemolytic Poisons, and Hemorrhage , J. M. Research 7:435-463, 1902. 7. Hektoen, Ludvig: On the Formation and Fate of Antibodies, Harvey Lectures , Philadelphia. J. B. Lippincott Company, 1910, pp. 150-191. 8. Ashby, Winifred: Study of Transfused Blood. II. Blood Destruction in Pernicious Anemia , J. Exper. Med. 34:147-166 ( (Aug.) ) 1921.Crossref 9. Giffin, H. Z., and Szlapka, T. L.: The Treatment of Pernicious Anemia by Splenectomy , J. A. M. A. 76:290-295 ( (Jan. 29) ) 1921.Crossref 10. Giffin, H. Z.: Present Status of Splenectomy as a Therapeutic Measure , Minnesota Med. 4:132-138 ( (March) ) 1921. 11. Mann. F. C.: Some Bodily Changes During Anesthesia . J. A. M. A. 67:172-175 ( (July 15) ) 1916.Crossref 12. Drinker, C. K.; Drinker, Katherine, and Kreutzman, H. A.: Influence of Procedures Designed to Increase the Rate of Blood Flow Through the Blood-Forming Organs—Hemorrhage and Infusion , J. Exper. Med. 27:383-397 ( (March) ) 1918.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

CHANGES IN THE MORPHOLOGY AND FUNCTION OF THE BONE MARROW AFTER SPLENECTOMY

JOHNSTONE, ERNEST M.
Archives of Surgery , Volume 5 (1) – Jul 1, 1922
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Publisher
American Medical Association
Copyright
Copyright © 1922 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1922.01110130168006
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Abstract

Abstract INTRODUCTION In this series of investigations on the bone marrow I have had a two-fold purpose: first, to devise a new method of studying marrow that would secure a connected picture of changes in the marrow, and second, to observe the function of the marrow after the removal of the spleen. The need of this investigation was suggested to me by my findings in a previous study1 of the blood changes after removal of the spleen for kala-azar.Hitherto most observations on the function of the marrow have been limited to single isolated specimens, usually secured at necropsy or by etherizing laboratory animals. A single specimen of bone marrow gives insufficient evidence. An adequate conception of the behavior of the marrow can be secured only by frequent observations (on the same person or laboratory animal) at regular intervals and over a period sufficiently long to afford a connected record References 1. Johnstone, E. M.: A Study of Blood Changes in Kala-Azar After Splenectomy , China M. J. 32:505-513, 1918. 2. Pearce, R. M.; Krumbhaar, F. B., and Frazier, C. H.: The Spleen and Anemia, Experimental and Clinical Studies , Philadelphia, J. B. Lippincott, 1918. 3. Bunting, C. H.: Experimental Anemias in the Rabbit , J. Exper. Med. 8:625-646, 1906.Crossref 4. Gruner, O. C.: The Biology of the Blood Cells, with a Glossary of Hematological Terms . Bristol, J. Wright and Sons, 1913. 5. Gulland, G. E., and Goodall, A.: The Blood, a Guide to Its Examination and to the Diagnosis and Treatment of Its Diseases , Edinburgh, W. Green and Sons, 1914, p. 96 and p. 110. 6. Warthin, A. S.: The Changes Produced in the Hemolymph Glands of the Sheep and Goat by Splenectomy, Hemolytic Poisons, and Hemorrhage , J. M. Research 7:435-463, 1902. 7. Hektoen, Ludvig: On the Formation and Fate of Antibodies, Harvey Lectures , Philadelphia. J. B. Lippincott Company, 1910, pp. 150-191. 8. Ashby, Winifred: Study of Transfused Blood. II. Blood Destruction in Pernicious Anemia , J. Exper. Med. 34:147-166 ( (Aug.) ) 1921.Crossref 9. Giffin, H. Z., and Szlapka, T. L.: The Treatment of Pernicious Anemia by Splenectomy , J. A. M. A. 76:290-295 ( (Jan. 29) ) 1921.Crossref 10. Giffin, H. Z.: Present Status of Splenectomy as a Therapeutic Measure , Minnesota Med. 4:132-138 ( (March) ) 1921. 11. Mann. F. C.: Some Bodily Changes During Anesthesia . J. A. M. A. 67:172-175 ( (July 15) ) 1916.Crossref 12. Drinker, C. K.; Drinker, Katherine, and Kreutzman, H. A.: Influence of Procedures Designed to Increase the Rate of Blood Flow Through the Blood-Forming Organs—Hemorrhage and Infusion , J. Exper. Med. 27:383-397 ( (March) ) 1918.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Jul 1, 1922

References

  • A Study of Blood Changes in Kala-Azar After Splenectomy
    Johnstone , E. M.
  • The Spleen and Anemia, Experimental and Clinical Studies
    Pearce , R. M.; Krumbhaar, F. B., and Frazier, C. H.
  • Experimental Anemias in the Rabbit
    Bunting , C. H.
  • The Biology of the Blood Cells, with a Glossary of Hematological Terms
    Gruner , O. C.
  • The Blood, a Guide to Its Examination and to the Diagnosis and Treatment of Its Diseases
    Gulland , G. E., and Goodall, A.
  • The Changes Produced in the Hemolymph Glands of the Sheep and Goat by Splenectomy, Hemolytic Poisons, and Hemorrhage
    Warthin , A. S.
  • On the Formation and Fate of Antibodies, Harvey Lectures
    Hektoen , Ludvig
  • Study of Transfused Blood. II. Blood Destruction in Pernicious Anemia
    Ashby , Winifred
  • The Treatment of Pernicious Anemia by Splenectomy
    Giffin , H. Z., and Szlapka, T. L.
  • Present Status of Splenectomy as a Therapeutic Measure
    Giffin , H. Z.
  • Some Bodily Changes During Anesthesia
    Mann . F. C.
  • Influence of Procedures Designed to Increase the Rate of Blood Flow Through the Blood-Forming Organs—Hemorrhage and Infusion
    Drinker , C. K.; Drinker, Katherine, and Kreutzman, H. A.