Abstract If psoriasis is a disease of systemic lipid metabolism, some deviation from the normal should be found in the serum lipoprotein levels of psoriatic patients. It has been shown that the lipid constituents in the serum, including phospholipids, neutral fats, triglycerides, cholesterol, and cholesterol esters, are carried primarily as lipid-protein complexes called lipoproteins.1,2 The best method at present for studying these relatively unstable compounds is by the technique of ultracentrifugation. This study was undertaken to determine what changes, if any, occur in serum lipoprotein fractions of patients with psoriasis when treated by various means. In recent publications it has been demonstrated that patients with psoriasis show no consistent variation from the normal with regard to serum lipoproteins. No significant abnormalities were found by Lea et al.3 in the serum lipoproteins of patients with psoriasis, and these findings were confirmed in our own preliminary report.4 The possibility remains, References 1. Gofman, J. W.; Lindgren, F. T., and Elliott, H. A.: Ultracentrifugal Studies of Lipoproteins of Human Serum , J. Biol. Chem. 179:973-979, 1949. 2. De Lalla, O. F., and Gofman, J. W.: Ultracentrifugal Analysis of Serum Lipoproteins , in Glick, D.: Methods of Biochemical Analysis , Vol. 1, New York, Interstate Publishers, Inc., 1954. 3. Lea, W. A., Jr.; Cornish, H. H., and Block, W. D.: Studies on Serum Lipids, Proteins, and Lipoproteins in Psoriasis , J. Invest. Dermat. 30: 181-185 ( (April) ) 1958. 4. Shapiro, E. M.; Knox, J. M., and Grundy, S.: Serum Lipoproteins in Psoriasis , J. Invest. Dermat. 31:215-217 ( (Oct.) ) 1958.Crossref 5. Pearson, S.; Stern, S., and McGavack, T. H.: A Rapid Procedure for the Determination of Serum Cholesterol , J. Clin. Endocrinol. 12:1245-1246, 1952.Crossref 6. Gross, P., and Kesten, B. M.: The Treatment of Psoriasis as a Disturbance of Lipid Metabolism , New York J. Med. 50:2683-2686 ( (Nov. 15) ) 1950. 7. Combes, F.: Management of Psoriasis as a Metabolic Lipid Disturbance , New York J. Med. 54:1945-1949 ( (July 1) ) 1954.
A.M.A. Archives of Dermatology – American Medical Association
Published: Jun 1, 1960