Abstract In a recent experimental study of the factors causing death in cases of uncomplicated acute intestinal obstruction a serious and rapid fall in the volume of circulating plasma was observed.1 This extreme loss of plasma occurred as a result of distention of the obstructed small intestine and continued as long as the distention continued. Evidence was obtained that "intravenous plasma in amounts adequate to replace that lost as a result of obstructing and distending the empty small intestine confers a protective influence sufficient to markedly prolong the life of the animal."2 This effect was not secured by the use of equal or larger amounts of physiologic solution of sodium chloride. Since distention is responsible for the loss of plasma, decompression should be accompanied by a retardation of the loss or indeed by a gain of plasma volume. Experimental data in confirmation of this inference are presented here. METHOD References 1. Gendel, S., and Fine, J.: The Effect of Acute Intestinal Obstruction on the Blood and Plasma Volume , Ann. Surg. 110:25, 1939.Crossref 2. Fine, J., and Gendel, S.: Plasma Transfusion in Experimental Intestinal Obstruction, Ann. Surg., to be published. 3. Gibson, J. G., and Evelyn, K. A.: Clinical Studies of the Blood Volume: IV. Adaptation of the Method to the Photoelectric Microcolorimeter , J. Clin. Investigation 17:153, 1938.Crossref 4. Fine, J.; Frehling, S., and Starr, A.: Experimental Observations on the Effect of Ninety-Five Per Cent Oxygen on the Absorption of Air from the Body Tissues , J. Thoracic Surg. 4:635, 1935. 5. Unpublished data. 6. Elman, R.: The Danger of Sudden Deflation of Acutely Distended Bowel in Late Low Intestinal Obstruction , Am. J. Surg. 26:438, 1934.Crossref
Archives of Surgery – American Medical Association
Published: Apr 1, 1940
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