Letters Mirzakhani et al state that data suggest the safety of LDA Antonis Voutetakis, MD, PhD treatment based on the Etude EPIdémiologique sur les Petits Panagiota Pervanidou, MD, PhD Ages Gestationnels (EPIPAGE) study, a significant observa- Christina Kanaka-Gantenbein, MD, PhD tional study that recruited participants more than 20 years ago Author Affiliations: First Department of Pediatrics, School of Medicine, and obtained medical information retrospectively. There- National and Kapodistrian University of Athens, Athens, Greece. fore, important limitations with respect to the study’s evalu- Corresponding Author: Antonis Voutetakis, MD, PhD, First Department of ation of LDA treatment exist: nonrandomization (reflected in Pediatrics, School of Medicine, National and Kapodistrian University of Athens, significant differences between the aspirin-treated and non- Thivon 1, Athens, 11527, Greece (firstname.lastname@example.org). treated group), the rate of loss to follow-up (significantly higher Published Online: November 4, 2019. doi:10.1001/jamapediatrics.2019 in the no-LDA group compared with the LDA group; 27% vs .4021 16%), and inability to control or follow actual dosing and com- Conflict of Interest Disclosures: None reported. pliance. Notably, the study focused in neonates born very pre- 1. Voutetakis A, Pervanidou P, Kanaka-Gantenbein C. Aspirin for the prevention of preeclampsia and potential consequences for fetal brain development. JAMA term
JAMA Pediatrics – American Medical Association
Published: Jan 11, 2020
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