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Challenges of Non–Intention-to-Treat Analyses

Challenges of Non–Intention-to-Treat Analyses This Viewpoint reviews the rationale for intention-to-treat (ITT) analyses of randomized trials, explains how commonly used alternatives reintroduce confounding that randomization is intended to eliminate, and emphasizes that even an ITT analysis is no substitute for informed scientific and clinical judgement when interpreting trial results. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Challenges of Non–Intention-to-Treat Analyses

JAMA , Volume 321 (2) – Jan 15, 2019

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.19192
Publisher site
See Article on Publisher Site

Abstract

This Viewpoint reviews the rationale for intention-to-treat (ITT) analyses of randomized trials, explains how commonly used alternatives reintroduce confounding that randomization is intended to eliminate, and emphasizes that even an ITT analysis is no substitute for informed scientific and clinical judgement when interpreting trial results.

Journal

JAMAAmerican Medical Association

Published: Jan 15, 2019

References