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Cerebral Ventricular Size and Neuropsychological Impairment in Young Chronic Schizophrenics: Measurement by the Standardized Luria-Nebraska Neuropsychological Battery

Cerebral Ventricular Size and Neuropsychological Impairment in Young Chronic Schizophrenics:... Abstract • The relationship between size of cerebral ventricles in chronic schizophrenics and performance on a comprehensive neuropsychological battery, the Standardized Luria-Nebraska Neuropsychological Battery, was investigated. Ventricular size was determined by using a planimeter to measure the size of the lateral ventricles and the ventricular body, if present, on the computerized tomographic (CT) scan image that showed the largest lateral ventricles. This number was divided by the size of the brain as a whole on the same image of the CT scan to yield a ventricular brain ratio. This ratio was then correlated with the scores on the Luria-Nebraska Neuropsychological Battery. Eight of the 14 scales of the Luria-Nebraska Neuropsychological Battery correlated significantly at the .05 level with the ventricular brain ratio in a sample of 42 chronic schizophrenics with an average age of 32.3 years. Overall, there was a multiple correlation of .72 between the ventricular brain ratio and Luria scores. The overall ventricular brain ratio for the schizophrenics was significantly above that found in normal populations. Changes in the size of the ventricles in schizophrenics appear to have significant correlates with measures of neuropsychological performance. References 1. Golden CJ: Diagnosis and Rehabilitation in Clinical Neuropsychology . Springfield, Ill, Charles C Thomas Publisher, 1978. 2. Lezak M: Neuropsychological assessment . New York, Oxford Press, 1976. 3. Heaton RK, Baade LE, Johnson KL: Neuropsychological test results associated with psychiatric disorders in adults . Psychol Bull 85:141-162, 1978.Crossref 4. Klonoff H, Fibiger C, Hutton GH: Neuropsychological patterns in chronic schizophrenia . J Nerv Ment Dis 150:291-300, 1970.Crossref 5. Watson CG, Thomas RW, Andersen D, et al: Differentiation of organics from schizophrenics at two chronicity levels by use of the Reitan-Halstead organic test battery . J Consult Clin Psychol 32:679-684, 1968.Crossref 6. Watson CG: Separation of brain-damaged from schziophrenic patients by Reitan-Halstead pattern analysis: An unsuccessful replication . Psychol Rep 29:1343-1346, 1971.Crossref 7. DeWolfe AS, Barrell RP, Becker BC, et al: Intellectual deficit in chronic schizophrenia and brain damage . J Consult Clin Psychol 36:197-204, 1971.Crossref 8. L'Abate L, Boelling GM, Hutton RD, et al: The diagnostic usefulness of four potential tests of brain damage . J Clin Psychol 26:479, 1962. 9. Corsellis JAN: Psychoses of obscure pathology , in Blackwood W, Corsellis JAN (eds): Greenfield's Neuropathology , ed 3. Chicago, Year Book Medical Publishers, 1976. 10. Mirsky AF: Neuropsychological bases of schizophrenia . Annu Rev Psychol 20:321-348, 1969.Crossref 11. Wolfe SG, Berle BB: The Biology of the Schizophrenic Process . New York, Plenum Press Inc, 1976. 12. Fisman M: The brain stem in psychosis . Br J Psychiatry 126:414-422, 1975.Crossref 13. Tatetsu S: A contribution to the morphological background of schizophrenia with special reference to the findings in the telencephalon . Acta Neuropathol 3:558-571, 1964.Crossref 14. Feinberg I: Recent sleep research: Findings in schizophrenia and some possible implications for the mechanisms of action of chlorpromazine and for the neurophysiology of delirium , in Sinkar D (ed): Schizophrenia: Current Concepts and Research . New York, PJD Publications, 1969. 15. Tucker GJ, Detre T, Harrow M, et al: Behavior and symptoms of psychiatric patients and the electroencephalogram . Arch Gen Psychiatry 12:278-286, 1965.Crossref 16. Haug JO: Pneumoencephalographic studies in mental disease . Acta Psychiatr Scand 38:1-115, 1962.Crossref 17. Young IJ, Crampton AR: Cerebrospinal fluid uric acid levels in cerebral atrophy occurring in psychiatric and neurologic patients . Biol Psychiatry 8:281-292, 1974. 18. Weinberger DR, Torrey EF, Neophytides AN, et al: Lateral cerebral ventricular enlargement in chronic schizophrenics . Arch Gen Psychiatry 36:735-739, 1979.Crossref 19. Johnstone EC, Crowe TJ, Frith CD, et al: Cerebral ventricular size and cognitive impairment in chronic schizophrenia . Lancet 2:924-926, 1976.Crossref 20. Kingsley D, Trimble M: Cerebral ventricular size in chronic schizophrenia . Lancet 1:278-279, 1978. 21. Moore MT, Nathan D, Elliott AR, et al: Encephalographic studies in schizophrenia (dementia praecox) . Am J Psychiatry 89:801-810, 1933. 22. Matthews CG, Booker HE: Pneumoencephalographic measurements and neuropsychological test performance in human adults . Cortex 8:69-92, 1972.Crossref 23. Lindgren E: Some aspects on the technique of encephalography . Acta Radiol 31:161-177, 1949.Crossref 24. Weiner WB: Psychodiagnosis of Schizophrenia . New York, John Wiley & Sons Inc, 1966. 25. Withers E, Hinton J: Three forms of the clinical tests of the sensorium and their reliability . Br J Psychiatry 119:1-8, 1971.Crossref 26. Christensen AL: The Luria Neuropsychological Investigation . New York, Spectrum Press, 1975. 27. Golden CJ, Hammeke TA, Purisch AD: Diagnostic validity of a standardized neuropsychological battery derived from Luria's neuropsychological tests . J Consult Clin Psychol 46:1258-1265, 1978.Crossref 28. Golden CJ, Purisch AD, Hammeke TA: The Luria-Nebraska Neuropsychological Battery: A Manual for Clinical and Experimental Uses . Lincoln, Neb, University of Nebraska Press, 1979. 29. Hammeke TA, Golden CJ, Purisch AD: Standardized, short and comprehensive neuropsychological test battery based on Luria's neuropsychological evaluation . Int J Neurosci 8:135-141, 1978.Crossref 30. Moses J, Golden CJ: Cross validation of the discriminative effectiveness of the standardized Luria neuropsychological battery . Int J Neurosci 9:149-155, 1979.Crossref 31. Purisch AD, Golden CJ, Hammeke TA: Discrimination of schizophrenic and brain injured patients by a standardized version of Luria's neuropsychological tests . J Consult Clin Psychol 46:1266-1273, 1978.Crossref 32. Moses J, Golden CJ: The discrimination between schizophrenic and brain damaged patients using the Luria-Nebraska neuropsychological test battery . Int J Neurosci , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Cerebral Ventricular Size and Neuropsychological Impairment in Young Chronic Schizophrenics: Measurement by the Standardized Luria-Nebraska Neuropsychological Battery

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1980.01780190017001
Publisher site
See Article on Publisher Site

Abstract

Abstract • The relationship between size of cerebral ventricles in chronic schizophrenics and performance on a comprehensive neuropsychological battery, the Standardized Luria-Nebraska Neuropsychological Battery, was investigated. Ventricular size was determined by using a planimeter to measure the size of the lateral ventricles and the ventricular body, if present, on the computerized tomographic (CT) scan image that showed the largest lateral ventricles. This number was divided by the size of the brain as a whole on the same image of the CT scan to yield a ventricular brain ratio. This ratio was then correlated with the scores on the Luria-Nebraska Neuropsychological Battery. Eight of the 14 scales of the Luria-Nebraska Neuropsychological Battery correlated significantly at the .05 level with the ventricular brain ratio in a sample of 42 chronic schizophrenics with an average age of 32.3 years. Overall, there was a multiple correlation of .72 between the ventricular brain ratio and Luria scores. The overall ventricular brain ratio for the schizophrenics was significantly above that found in normal populations. Changes in the size of the ventricles in schizophrenics appear to have significant correlates with measures of neuropsychological performance. References 1. Golden CJ: Diagnosis and Rehabilitation in Clinical Neuropsychology . Springfield, Ill, Charles C Thomas Publisher, 1978. 2. Lezak M: Neuropsychological assessment . New York, Oxford Press, 1976. 3. Heaton RK, Baade LE, Johnson KL: Neuropsychological test results associated with psychiatric disorders in adults . Psychol Bull 85:141-162, 1978.Crossref 4. Klonoff H, Fibiger C, Hutton GH: Neuropsychological patterns in chronic schizophrenia . J Nerv Ment Dis 150:291-300, 1970.Crossref 5. Watson CG, Thomas RW, Andersen D, et al: Differentiation of organics from schizophrenics at two chronicity levels by use of the Reitan-Halstead organic test battery . J Consult Clin Psychol 32:679-684, 1968.Crossref 6. Watson CG: Separation of brain-damaged from schziophrenic patients by Reitan-Halstead pattern analysis: An unsuccessful replication . Psychol Rep 29:1343-1346, 1971.Crossref 7. DeWolfe AS, Barrell RP, Becker BC, et al: Intellectual deficit in chronic schizophrenia and brain damage . J Consult Clin Psychol 36:197-204, 1971.Crossref 8. L'Abate L, Boelling GM, Hutton RD, et al: The diagnostic usefulness of four potential tests of brain damage . J Clin Psychol 26:479, 1962. 9. Corsellis JAN: Psychoses of obscure pathology , in Blackwood W, Corsellis JAN (eds): Greenfield's Neuropathology , ed 3. Chicago, Year Book Medical Publishers, 1976. 10. Mirsky AF: Neuropsychological bases of schizophrenia . Annu Rev Psychol 20:321-348, 1969.Crossref 11. Wolfe SG, Berle BB: The Biology of the Schizophrenic Process . New York, Plenum Press Inc, 1976. 12. Fisman M: The brain stem in psychosis . Br J Psychiatry 126:414-422, 1975.Crossref 13. Tatetsu S: A contribution to the morphological background of schizophrenia with special reference to the findings in the telencephalon . Acta Neuropathol 3:558-571, 1964.Crossref 14. Feinberg I: Recent sleep research: Findings in schizophrenia and some possible implications for the mechanisms of action of chlorpromazine and for the neurophysiology of delirium , in Sinkar D (ed): Schizophrenia: Current Concepts and Research . New York, PJD Publications, 1969. 15. Tucker GJ, Detre T, Harrow M, et al: Behavior and symptoms of psychiatric patients and the electroencephalogram . Arch Gen Psychiatry 12:278-286, 1965.Crossref 16. Haug JO: Pneumoencephalographic studies in mental disease . Acta Psychiatr Scand 38:1-115, 1962.Crossref 17. Young IJ, Crampton AR: Cerebrospinal fluid uric acid levels in cerebral atrophy occurring in psychiatric and neurologic patients . Biol Psychiatry 8:281-292, 1974. 18. Weinberger DR, Torrey EF, Neophytides AN, et al: Lateral cerebral ventricular enlargement in chronic schizophrenics . Arch Gen Psychiatry 36:735-739, 1979.Crossref 19. Johnstone EC, Crowe TJ, Frith CD, et al: Cerebral ventricular size and cognitive impairment in chronic schizophrenia . Lancet 2:924-926, 1976.Crossref 20. Kingsley D, Trimble M: Cerebral ventricular size in chronic schizophrenia . Lancet 1:278-279, 1978. 21. Moore MT, Nathan D, Elliott AR, et al: Encephalographic studies in schizophrenia (dementia praecox) . Am J Psychiatry 89:801-810, 1933. 22. Matthews CG, Booker HE: Pneumoencephalographic measurements and neuropsychological test performance in human adults . Cortex 8:69-92, 1972.Crossref 23. Lindgren E: Some aspects on the technique of encephalography . Acta Radiol 31:161-177, 1949.Crossref 24. Weiner WB: Psychodiagnosis of Schizophrenia . New York, John Wiley & Sons Inc, 1966. 25. Withers E, Hinton J: Three forms of the clinical tests of the sensorium and their reliability . Br J Psychiatry 119:1-8, 1971.Crossref 26. Christensen AL: The Luria Neuropsychological Investigation . New York, Spectrum Press, 1975. 27. Golden CJ, Hammeke TA, Purisch AD: Diagnostic validity of a standardized neuropsychological battery derived from Luria's neuropsychological tests . J Consult Clin Psychol 46:1258-1265, 1978.Crossref 28. Golden CJ, Purisch AD, Hammeke TA: The Luria-Nebraska Neuropsychological Battery: A Manual for Clinical and Experimental Uses . Lincoln, Neb, University of Nebraska Press, 1979. 29. Hammeke TA, Golden CJ, Purisch AD: Standardized, short and comprehensive neuropsychological test battery based on Luria's neuropsychological evaluation . Int J Neurosci 8:135-141, 1978.Crossref 30. Moses J, Golden CJ: Cross validation of the discriminative effectiveness of the standardized Luria neuropsychological battery . Int J Neurosci 9:149-155, 1979.Crossref 31. Purisch AD, Golden CJ, Hammeke TA: Discrimination of schizophrenic and brain injured patients by a standardized version of Luria's neuropsychological tests . J Consult Clin Psychol 46:1266-1273, 1978.Crossref 32. Moses J, Golden CJ: The discrimination between schizophrenic and brain damaged patients using the Luria-Nebraska neuropsychological test battery . Int J Neurosci , to be published.

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Jun 1, 1980

References

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