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CEREBRAL CALCIFICATION IN A CASE OF CHRONIC PROGRESSIVE CHOREA

CEREBRAL CALCIFICATION IN A CASE OF CHRONIC PROGRESSIVE CHOREA Abstract Pathologic infiltration of calcium in the central nervous system is not easily recognized symptomatically. The clinical picture ranges from absence of signs during life, with infiltration as an observation at autopsy, to milder symptoms of headache, dizziness and vomiting and to grand and petit mal attacks, which Geyelin and Penfield1 called "cerebral calcification epilepsy," related to "endarteritis calcificans cerebri." Symptoms in which psychiatrists are particularly interested are the organic psychoses associated with such a pathologic process. The problem of diagnosis in these cases is well demonstrated in the reports of Holschewnekoff,2 Mallory,3 Hansemann,4 Bassoe and Hassin,5 Lisa and Hirschhorn,6 Pick,7 Simon8 and Jervis.9 The case of cerebral calcification reported here has both clinical and pathologic importance. Clinically, the case was repeatedly diagnosed as one of Huntington's chorea with psychosis. Pathologically, the changes were those fundamental in chronic progressive chorea, with additional References 1. Geyelin, H. R., and Penfield, W.: Cerebral Calcification Epilepsy , Arch. Neurol. & Psychiat. 21:1020 ( (May) ) 1929. 2. Holschewnekoff, O.: Ueber Degeneration der Hirngefässe , Virchows Arch. f. path. Anat. 112:552, 1888. 3. Mallory, F. B.: Contribution to the Study of Calcareous Concretions in the Brain , J. Path. & Bact. 3:110, 1892. 4. Hansemann: Ein casuistischer Beitrag zur Verkalkung der Gehirngefässe , Verhandl. d. deutsch. path. Gesellsch. 2:399, 1900. 5. Bassoe, P., and Hassin, G. B.: Calcification of the Cerebral Vessels, with a Clinical Picture Simulating Brain Tumor , Arch. Neurol. & Psychiat. 6:359 ( (Oct.) ) 1921. 6. Lisa, J. R., and Hirschhorn, L.: Subdural Calcium Deposit of the Spinal Cord , Arch. Neurol. & Psychiat. 28:416 ( (Aug.) ) 1932. 7. Pick, A.: Calcification of the Finer Cerebral Vessels with Remarks upon Its Clinical Significance , Am. J. Insan. 61:419, 1905. 8. Simon, T.: Ausgedehnte Verkalkung der Hirngefässe bei einer Idioten , Virchows Arch. f. path. Anat. 55:534, 1872. 9. Jervis, G.: Calcification in an Idiot, personal communication to the author. 10. Davidson, C.; Goodhart, S. P., and Shlionsky, H.: Chronic Progressive Chorea: The Pathogenesis and Mechanism; a Histopathologic Study , Arch. Neurol. & Psychiat. 27:906 ( (April) ) 1932. 11. Adrian, W.: Verbesserte Methode der Gelatineinbettung für Gefrierschnitte , Centralbl. f. allg. Path. u. path. Anat. 33:201, 1922. 12. Cameron, G. R.: The Staining of Calcium , J. Path. & Bact. 33:201, 1922. 13. Lipshutz, D. M.: Etude anatomo-pathologique des chorées chroniques . Rev. neurol. 66:201 ( (Aug.) ) 1936. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

CEREBRAL CALCIFICATION IN A CASE OF CHRONIC PROGRESSIVE CHOREA

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Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1939.02270240166011
Publisher site
See Article on Publisher Site

Abstract

Abstract Pathologic infiltration of calcium in the central nervous system is not easily recognized symptomatically. The clinical picture ranges from absence of signs during life, with infiltration as an observation at autopsy, to milder symptoms of headache, dizziness and vomiting and to grand and petit mal attacks, which Geyelin and Penfield1 called "cerebral calcification epilepsy," related to "endarteritis calcificans cerebri." Symptoms in which psychiatrists are particularly interested are the organic psychoses associated with such a pathologic process. The problem of diagnosis in these cases is well demonstrated in the reports of Holschewnekoff,2 Mallory,3 Hansemann,4 Bassoe and Hassin,5 Lisa and Hirschhorn,6 Pick,7 Simon8 and Jervis.9 The case of cerebral calcification reported here has both clinical and pathologic importance. Clinically, the case was repeatedly diagnosed as one of Huntington's chorea with psychosis. Pathologically, the changes were those fundamental in chronic progressive chorea, with additional References 1. Geyelin, H. R., and Penfield, W.: Cerebral Calcification Epilepsy , Arch. Neurol. & Psychiat. 21:1020 ( (May) ) 1929. 2. Holschewnekoff, O.: Ueber Degeneration der Hirngefässe , Virchows Arch. f. path. Anat. 112:552, 1888. 3. Mallory, F. B.: Contribution to the Study of Calcareous Concretions in the Brain , J. Path. & Bact. 3:110, 1892. 4. Hansemann: Ein casuistischer Beitrag zur Verkalkung der Gehirngefässe , Verhandl. d. deutsch. path. Gesellsch. 2:399, 1900. 5. Bassoe, P., and Hassin, G. B.: Calcification of the Cerebral Vessels, with a Clinical Picture Simulating Brain Tumor , Arch. Neurol. & Psychiat. 6:359 ( (Oct.) ) 1921. 6. Lisa, J. R., and Hirschhorn, L.: Subdural Calcium Deposit of the Spinal Cord , Arch. Neurol. & Psychiat. 28:416 ( (Aug.) ) 1932. 7. Pick, A.: Calcification of the Finer Cerebral Vessels with Remarks upon Its Clinical Significance , Am. J. Insan. 61:419, 1905. 8. Simon, T.: Ausgedehnte Verkalkung der Hirngefässe bei einer Idioten , Virchows Arch. f. path. Anat. 55:534, 1872. 9. Jervis, G.: Calcification in an Idiot, personal communication to the author. 10. Davidson, C.; Goodhart, S. P., and Shlionsky, H.: Chronic Progressive Chorea: The Pathogenesis and Mechanism; a Histopathologic Study , Arch. Neurol. & Psychiat. 27:906 ( (April) ) 1932. 11. Adrian, W.: Verbesserte Methode der Gelatineinbettung für Gefrierschnitte , Centralbl. f. allg. Path. u. path. Anat. 33:201, 1922. 12. Cameron, G. R.: The Staining of Calcium , J. Path. & Bact. 33:201, 1922. 13. Lipshutz, D. M.: Etude anatomo-pathologique des chorées chroniques . Rev. neurol. 66:201 ( (Aug.) ) 1936.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Dec 1, 1939

References