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Cephalothoracopagus Janiceps Malformation: A Contribution to the Pathogenesis of Cerebral Malformation

Cephalothoracopagus Janiceps Malformation: A Contribution to the Pathogenesis of Cerebral... Abstract • We report the first histologic findings of the CNS in cephalothoracopagus janiceps monosymmetros. The findings are compared with the other ten reported cases of this type of conjoined twin. The faces and CNSs showed asymmetry of development manifested chiefly in the prosencephalon, specifically the cortical gyri, corpus callosum, and subependymal mantle layer. It is difficult to explain discordance for congenital malformations in monovular or conjoined twins by either genetic or environmental mechanisms. It appears related to the vascular supply of the brain and a state of chronic ischemia rather than to a discrete insult and developmental arrest at a specific time during embryogenesis. References 1. Grundfest TH, Weisenfeld S: A case of cephalothoracopagus . NY State J Med . 1950;50:576-579. 2. Musset R, Roux Ch, Agogué M, et al: Une observation de monstre double type Janus . Bull Fed Soc Gynecol Obstet Lang Fr 1970;22:500-506. 3. Buchta RM: Anencephaly in female thoracopagus conjoined twins . Clin Pediatr 1973;12:598-599.Crossref 4. Wilson JG, Fraser FC (eds): Handbook of Teratology I . New York, Plenum Press, 1977, pp 3-45. 5. Slipka J, Kočová J: The absence of one umbilical artery in malformed monozygous twins . Acta Genet Med Gemellol 1970;19:567-575. 6. Schwalbe E: Die Morphologie der Misbildungen des Menschen und der Tiere. II . Jena, East Germany, Gustav Fischer Verlag, 1907, pp 175-220. 7. Gunter JU: Cephalothoracopagus monosymmetros: Report of a case . Am J Pathol 1946;22:855-865. 8. Shaaban WH, Hussein M, El-Minawi MF, et al: Conjoined twins . J Egypt Med Assoc 1970;53:442-466. 9. Finola GC: Cephalothoracopagus (double monster) . Am J Obstet Gynecol 1934;28:455-456. 10. Forthomme J: Janus symétrique . Ann Anat Pathol 1968;13:347-359. 11. Storrock MM, McKenzie J: The abnormalities and genesis of cephalothoracopagus (Janiceps) twins . Anat Anz 1973;133:350-362. 12. Abbot ME, Kaufmann J: Double monster of Janus type (cephalothoracopagus monosymmetros cyclopos synotus) . Int Assoc Med Mus Bull 1916;6:95-101. 13. Bartlett RC: Cephalothoracopagus: Report of a case . Arch Pathol 1959;68:292-298. 14. Jawa F: A case of cephalothoracopagus syncephalus . Sb Ved Pr Lek Fak Univ Karlovy 1972;15( (suppl) ):417-420. 15. Khudr G, Benirschke K: Discordant monozygous twins associated with amnion rupture: A case report . Obstet Gynecol 1972;39:713-716. 16. Kudhr G, Benirschke K: Discordant monozygous twins associted with amnion rupture: A case report . Obstet Gynecol 1972;39:713-716. 17. Potter EL, Craig JM: Pathology of the Fetus and the Infant , ed 3. Chicago, Year Book Medical Publishers Inc, 1975. 18. Nance WE: Anencephaly and spina bifida: A possible example of cytoplasmic inheritance in man . Nature 1969;224:373-375.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Cephalothoracopagus Janiceps Malformation: A Contribution to the Pathogenesis of Cerebral Malformation

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Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1981.00510020061009
Publisher site
See Article on Publisher Site

Abstract

Abstract • We report the first histologic findings of the CNS in cephalothoracopagus janiceps monosymmetros. The findings are compared with the other ten reported cases of this type of conjoined twin. The faces and CNSs showed asymmetry of development manifested chiefly in the prosencephalon, specifically the cortical gyri, corpus callosum, and subependymal mantle layer. It is difficult to explain discordance for congenital malformations in monovular or conjoined twins by either genetic or environmental mechanisms. It appears related to the vascular supply of the brain and a state of chronic ischemia rather than to a discrete insult and developmental arrest at a specific time during embryogenesis. References 1. Grundfest TH, Weisenfeld S: A case of cephalothoracopagus . NY State J Med . 1950;50:576-579. 2. Musset R, Roux Ch, Agogué M, et al: Une observation de monstre double type Janus . Bull Fed Soc Gynecol Obstet Lang Fr 1970;22:500-506. 3. Buchta RM: Anencephaly in female thoracopagus conjoined twins . Clin Pediatr 1973;12:598-599.Crossref 4. Wilson JG, Fraser FC (eds): Handbook of Teratology I . New York, Plenum Press, 1977, pp 3-45. 5. Slipka J, Kočová J: The absence of one umbilical artery in malformed monozygous twins . Acta Genet Med Gemellol 1970;19:567-575. 6. Schwalbe E: Die Morphologie der Misbildungen des Menschen und der Tiere. II . Jena, East Germany, Gustav Fischer Verlag, 1907, pp 175-220. 7. Gunter JU: Cephalothoracopagus monosymmetros: Report of a case . Am J Pathol 1946;22:855-865. 8. Shaaban WH, Hussein M, El-Minawi MF, et al: Conjoined twins . J Egypt Med Assoc 1970;53:442-466. 9. Finola GC: Cephalothoracopagus (double monster) . Am J Obstet Gynecol 1934;28:455-456. 10. Forthomme J: Janus symétrique . Ann Anat Pathol 1968;13:347-359. 11. Storrock MM, McKenzie J: The abnormalities and genesis of cephalothoracopagus (Janiceps) twins . Anat Anz 1973;133:350-362. 12. Abbot ME, Kaufmann J: Double monster of Janus type (cephalothoracopagus monosymmetros cyclopos synotus) . Int Assoc Med Mus Bull 1916;6:95-101. 13. Bartlett RC: Cephalothoracopagus: Report of a case . Arch Pathol 1959;68:292-298. 14. Jawa F: A case of cephalothoracopagus syncephalus . Sb Ved Pr Lek Fak Univ Karlovy 1972;15( (suppl) ):417-420. 15. Khudr G, Benirschke K: Discordant monozygous twins associated with amnion rupture: A case report . Obstet Gynecol 1972;39:713-716. 16. Kudhr G, Benirschke K: Discordant monozygous twins associted with amnion rupture: A case report . Obstet Gynecol 1972;39:713-716. 17. Potter EL, Craig JM: Pathology of the Fetus and the Infant , ed 3. Chicago, Year Book Medical Publishers Inc, 1975. 18. Nance WE: Anencephaly and spina bifida: A possible example of cytoplasmic inheritance in man . Nature 1969;224:373-375.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Feb 1, 1981

References