Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

CENTRAL NERVOUS SYSTEM IN VITAMIN E-DEFICIENT RATS

CENTRAL NERVOUS SYSTEM IN VITAMIN E-DEFICIENT RATS Abstract During the past two years there have appeared numerous articles1 dealing with the treatment of amyotrophic lateral sclerosis and other chronic degenerative diseases of the central nervous system with vitamin E in crude or purified form. These studies have been instigated by the currently accepted view that chronic vitamin E deficiency in rats brings about neurologic lesions more or less comparable to those found in human diseases. Since this is contrary to experience in this laboratory, we have undertaken anew a study of the question. REVIEW OF LITERATURE The first reference to possible alteration of neuromuscular function in cases of vitamin E deprivation is to be found in the paper of Evans and Burr,2 in which is described paralysis of suckling rats born of vitamin E—deficient mothers. No study was made at that time of the underlying pathologic process. Material from such rats, however, was available to Lipschütz, References 1. Bicknell, F.: Vitamin E in the Treatment of Muscular Dystrophies and Nervous Diseases , Lancet 1:10, 1940.Crossref 2. Stone, S.: Treatment of Muscular Dystrophies and Allied Conditions: Preliminary Report on Use of Vitamin E (Wheat Germ Oil) , J. A. M. A. 114:2187 ( (June 1) ) 1940 3. Vitamin E in the Treatment of Muscle Disorders of Infancy and Childhood , J. Pediat. 18:310, 1941.Crossref 4. Wechsler, I. S.: Recovery in Amyotrophic Lateral Sclerosis Treated with Tocopherols (Vitamin E) , J. A. M. A. 114:948 ( (March 16) ) 1940 5. The Treatment of Amyotrophic Lateral Sclerosis with Vitamin E (Tocopherols) , Am. J. M. Sc. 200:765, 1940Crossref 6. Further Progress in the Treatment of Amyotrophic Lateral Sclerosis with the Tocopherols (Synthetic Vitamin E) , Tr. Am. Neurol. A. 66:59, 1940 7. Amyotrophic Lateral Sclerosis Treated with Synthetic Vitamin E , J. Nerv. & Ment. Dis. 93:353, 1941 8. Amyotrophic Lateral Sclerosis Treated with Synthetic Vitamin E , Arch. Neurol. & Psychiat. 45:873 ( (May) ) 1941. 9. Sheldon, C. H.; Butt, H. R., and Woltman, H. W.: Vitamin E (Synthetic α-Tocopherol) Therapy in Certain Neurologic Disorders (with Negative Results) , Proc. Staff Meet., Mayo Clin. 15:577, 1940. 10. Ravina, A., and Plichet, A.: Le traitement des dystrophies musculaires (myopathies) et de la sclérose latérale amyotrophique par la vitamine E , Presse méd. 48:886, 1940. 11. Weinberg, M. A., and Knoll, A. F.: Beneficial Effect on Amyotrophic Lateral Sclerosis Syndrome: Case in Which This Syndrome Was Precipitated by Sulphathiazole (Sulphanilamide Derivative) , M. Rec. 152:447, 1940. 12. Aguirre, M. R.: Use of Tocopherol Acetate, Synthetic Vitamin E, in Multiple Sclerosis and Amyotrophic Lateral Sclerosis , M. Bull. Vet. Admin. 17:376, 1941. 13. Denker, P. G., and Scheinman, L.: Treatment of Amyotrophic Lateral Sclerosis with Vitamin E (Alpha-Tocopherol) , J. A. M. A. 116:1893 ( (April 26) ) 1941. 14. Ferrebee, J. W.; Klingman, W. O., and Frantz, A. M.: Vitamin E and Vitamin B6: Clinical Experience in the Treatment of Muscular Dystrophy and Amyotrophic Lateral Sclerosis , J. A. M. A. 116:1895 ( (April 26) ) 1941. 15. Viets, H. R.; Trowbridge, S. H., Jr., and Gunderson, T.: Therapeutic Use of Vitamin E in Amyotrophic Lateral Sclerosis , J. Nerv. & Ment. Dis. 94:101, 1941. 16. Fitzgerald, G., and McArdle, B.: Vitamins E and B6 in Treatment of Muscular Dystrophy and Motor Neuron Disease , Brain 64:19, 1941. 17. Worster-Drought, C., and Shafar, J.: Motor Neurone Degeneration Treated with Vitamin E , Lancet 2:209, 1941. 18. Rosenberger, A. I.: Observations on the Treatment of Amyotrophic Lateral Sclerosis (Leucopoliomyelopathy) with Vitamin E , M. Rec. 154:97, 1941. 19. Slaughter, R. F., and Cleckley, H.: The Treatment of Intrinsic Cord Disease with Vitamin E , J. M. A. Georgia 3:106, 1941. 20. Doyle, A. M., and Merritt, H. H.: Vitamin Therapy of Diseases of the Neuro-Muscular Apparatus , Arch. Neurol. & Psychiat. 45:672 ( (April) ) 1941. 21. De Jong, R. N.: Vitamin E and Alpha-Tocopherol Therapy of Neuro-Muscular and Muscular Disorders , Arch. Neurol. & Psychiat. 46:375 ( (Dec.) ) 1941. 22. Mahoney, W. de G.: Neural Myatrophy and Vitamin E , South. M. J. 34:389, 1941. 23. Harvey, R. W., and Hume, P. B.: Vitamin E and Nervous Disease , California & West. Med. 55:293, 1941. 24. Meller, R. L.: An Evaluation of Vitamin E in the Treatment of Multiple Sclerosis and the Progressive Muscular Dystrophies , Journal-Lancet 61:471, 1941. 25. Bang, J.; Einarson, L.; Fog, A. M., and Ringsted, A.: Treatment of Some Neuro-Muscular Diseases with Synthetic Vitamin E (Amyotrophic Lateral Sclerosis and Progressive Muscular Dystrophy) , Nord. med. (Hospitalstid.) 10:1201, 1941. 26. Evans, H. M., and Burr, G. O.: Development of Paralysis in the Suckling Young of Mothers Deprived of Vitamin E , J. Biol. Chem. 76:273, 1928. 27. Lipschütz, M.: Les voies atteintes chez les jeunes rats manquant de vitamine E , Rev. neurol. 65:221, 1936. 28. Olcott, H. S.: The Paralysis in the Young of Vitamin E Deficient Female Rats , J. Nutrition 15:221, 1938. 29. Pappenheimer, A. M.: The Pathology of Nutritional Muscular Dystrophy in Young Rats , Am. J. Path. 15:179, 1939. 30. Barrie, M. M. O.: Vitamin E Deficiency in the Suckling Rat , Nature , London 142:799, 1938. 31. Verzàr, F.: Der Kreatin-Stoffwechsel bei der Muskeldystrophie durch E Vitamin-Mangel und seine Beeinflussung durch Tocopherol , Ztschr. f. Vitaminforsch. 9:242, 1939. 32. Demole, V., and Pfalz, H.: Neuromuskuläre Schädigungen von Jungtieren E- hypovitaminische Ratten, und ihre Behandlung mit synthetische Vitamin E . Schweiz. med. Wchnschr. 69:123, 1939. 33. Telford, I. R.; Emerson, G. A., and Evans, H. M.: Histological Changes in Skeletal Musculature of Paralysed Suckling Young of E-Low Rats , Proc. Soc. Exper. Biol. & Med. 41:291, 1939. 34. Einarson, L., and Ringsted, A.: Effect of Chronic Vitamin E Deficiency on the Nervous System and the Skeletal Musculature in Adult Rats , London. Oxford University Press, 1938. 35. Ringsted, A.: A Preliminary Note on the Appearance of Paresis in Adult Rats Suffering from Chronic Avitaminosis E , Biochem. J. 29:788, 1935. 36. Monnier, M.: Les altérations du systéme nerveux et des muscles striées chez le rat adulte carencé en vitamin E , Compt. rend. Soc. de phys. et hist. nat. 57:252, 1940. 37. Gutiérrez-Mahoney, W.; Mason, K. E., and Swanson, H.: The Neuropathology of Vitamin E Deficiency in the Rat , Am. J. Physiol. 133:308, 1941. 38. Mahoney.1q 39. Goettsch, M., and Pappenheimer, A. M.: α-Tocopherol Requirement of the Rat for Reproduction in the Female and Prevention of Muscular Dystrophy in the Young , J. Nutrition 22:463, 1941. 40. It is interesting that Einarson and Ringsted found that the disease developed less rapidly when oxidized lard was given. It has been the general experience that a diet with a high lard content favors the destruction of vitamin E. 41. De Gutierrez-Mahoney and associates used the Wesson modification of the Osborne-Mendel salt mixture, and Goettsch and Pappenheimer, the Hawk-Oser mixture. 42. Jakob, A.: Normale und pathologische Anatomie und Histologie des Grosshirns , Leipzig, Franz Deuticke, 1927. 43. Gurewitsch, M., and Bychowsky, G.: Zur Architektonik der Hirnrinde (Isocortex) des Hundes , J. f. Psychol. u. Neurol. 35:283, 1928. 44. Mettler, F. A.: Stain Technol. 7:95, 1932. 45. Ranson, S. W.: The Fasciculus Cerebrospinalis in the Albino Rat , Am. J. Anat. 14:411, 1914. 46. Burr, G. O.; Brown, W. R., and Mosely, R. L.: Paralysis in Old Age in Rats on a Diet Deficient in Vitamin E , Proc. Soc. Exper. Biol. & Med. 36:780, 1937. 47. Evans, H. M.; Emerson, G. A., and Telford, I. R.: Degeneration of Cross Striated Musculature in Vitamin E-Low Rats , Proc. Soc. Exper. Biol. & Med. 38:625, 1938. 48. Knowlton, G. C., and Hines, H. M.: Effect of Vitamin E Deficient Diet upon Skeletal Muscle , Proc. Soc. Exper. Biol. & Med. 38:665, 1938. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

CENTRAL NERVOUS SYSTEM IN VITAMIN E-DEFICIENT RATS

Loading next page...
 
/lp/american-medical-association/central-nervous-system-in-vitamin-e-deficient-rats-00a0XbFpPu
Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1942.02290100038004
Publisher site
See Article on Publisher Site

Abstract

Abstract During the past two years there have appeared numerous articles1 dealing with the treatment of amyotrophic lateral sclerosis and other chronic degenerative diseases of the central nervous system with vitamin E in crude or purified form. These studies have been instigated by the currently accepted view that chronic vitamin E deficiency in rats brings about neurologic lesions more or less comparable to those found in human diseases. Since this is contrary to experience in this laboratory, we have undertaken anew a study of the question. REVIEW OF LITERATURE The first reference to possible alteration of neuromuscular function in cases of vitamin E deprivation is to be found in the paper of Evans and Burr,2 in which is described paralysis of suckling rats born of vitamin E—deficient mothers. No study was made at that time of the underlying pathologic process. Material from such rats, however, was available to Lipschütz, References 1. Bicknell, F.: Vitamin E in the Treatment of Muscular Dystrophies and Nervous Diseases , Lancet 1:10, 1940.Crossref 2. Stone, S.: Treatment of Muscular Dystrophies and Allied Conditions: Preliminary Report on Use of Vitamin E (Wheat Germ Oil) , J. A. M. A. 114:2187 ( (June 1) ) 1940 3. Vitamin E in the Treatment of Muscle Disorders of Infancy and Childhood , J. Pediat. 18:310, 1941.Crossref 4. Wechsler, I. S.: Recovery in Amyotrophic Lateral Sclerosis Treated with Tocopherols (Vitamin E) , J. A. M. A. 114:948 ( (March 16) ) 1940 5. The Treatment of Amyotrophic Lateral Sclerosis with Vitamin E (Tocopherols) , Am. J. M. Sc. 200:765, 1940Crossref 6. Further Progress in the Treatment of Amyotrophic Lateral Sclerosis with the Tocopherols (Synthetic Vitamin E) , Tr. Am. Neurol. A. 66:59, 1940 7. Amyotrophic Lateral Sclerosis Treated with Synthetic Vitamin E , J. Nerv. & Ment. Dis. 93:353, 1941 8. Amyotrophic Lateral Sclerosis Treated with Synthetic Vitamin E , Arch. Neurol. & Psychiat. 45:873 ( (May) ) 1941. 9. Sheldon, C. H.; Butt, H. R., and Woltman, H. W.: Vitamin E (Synthetic α-Tocopherol) Therapy in Certain Neurologic Disorders (with Negative Results) , Proc. Staff Meet., Mayo Clin. 15:577, 1940. 10. Ravina, A., and Plichet, A.: Le traitement des dystrophies musculaires (myopathies) et de la sclérose latérale amyotrophique par la vitamine E , Presse méd. 48:886, 1940. 11. Weinberg, M. A., and Knoll, A. F.: Beneficial Effect on Amyotrophic Lateral Sclerosis Syndrome: Case in Which This Syndrome Was Precipitated by Sulphathiazole (Sulphanilamide Derivative) , M. Rec. 152:447, 1940. 12. Aguirre, M. R.: Use of Tocopherol Acetate, Synthetic Vitamin E, in Multiple Sclerosis and Amyotrophic Lateral Sclerosis , M. Bull. Vet. Admin. 17:376, 1941. 13. Denker, P. G., and Scheinman, L.: Treatment of Amyotrophic Lateral Sclerosis with Vitamin E (Alpha-Tocopherol) , J. A. M. A. 116:1893 ( (April 26) ) 1941. 14. Ferrebee, J. W.; Klingman, W. O., and Frantz, A. M.: Vitamin E and Vitamin B6: Clinical Experience in the Treatment of Muscular Dystrophy and Amyotrophic Lateral Sclerosis , J. A. M. A. 116:1895 ( (April 26) ) 1941. 15. Viets, H. R.; Trowbridge, S. H., Jr., and Gunderson, T.: Therapeutic Use of Vitamin E in Amyotrophic Lateral Sclerosis , J. Nerv. & Ment. Dis. 94:101, 1941. 16. Fitzgerald, G., and McArdle, B.: Vitamins E and B6 in Treatment of Muscular Dystrophy and Motor Neuron Disease , Brain 64:19, 1941. 17. Worster-Drought, C., and Shafar, J.: Motor Neurone Degeneration Treated with Vitamin E , Lancet 2:209, 1941. 18. Rosenberger, A. I.: Observations on the Treatment of Amyotrophic Lateral Sclerosis (Leucopoliomyelopathy) with Vitamin E , M. Rec. 154:97, 1941. 19. Slaughter, R. F., and Cleckley, H.: The Treatment of Intrinsic Cord Disease with Vitamin E , J. M. A. Georgia 3:106, 1941. 20. Doyle, A. M., and Merritt, H. H.: Vitamin Therapy of Diseases of the Neuro-Muscular Apparatus , Arch. Neurol. & Psychiat. 45:672 ( (April) ) 1941. 21. De Jong, R. N.: Vitamin E and Alpha-Tocopherol Therapy of Neuro-Muscular and Muscular Disorders , Arch. Neurol. & Psychiat. 46:375 ( (Dec.) ) 1941. 22. Mahoney, W. de G.: Neural Myatrophy and Vitamin E , South. M. J. 34:389, 1941. 23. Harvey, R. W., and Hume, P. B.: Vitamin E and Nervous Disease , California & West. Med. 55:293, 1941. 24. Meller, R. L.: An Evaluation of Vitamin E in the Treatment of Multiple Sclerosis and the Progressive Muscular Dystrophies , Journal-Lancet 61:471, 1941. 25. Bang, J.; Einarson, L.; Fog, A. M., and Ringsted, A.: Treatment of Some Neuro-Muscular Diseases with Synthetic Vitamin E (Amyotrophic Lateral Sclerosis and Progressive Muscular Dystrophy) , Nord. med. (Hospitalstid.) 10:1201, 1941. 26. Evans, H. M., and Burr, G. O.: Development of Paralysis in the Suckling Young of Mothers Deprived of Vitamin E , J. Biol. Chem. 76:273, 1928. 27. Lipschütz, M.: Les voies atteintes chez les jeunes rats manquant de vitamine E , Rev. neurol. 65:221, 1936. 28. Olcott, H. S.: The Paralysis in the Young of Vitamin E Deficient Female Rats , J. Nutrition 15:221, 1938. 29. Pappenheimer, A. M.: The Pathology of Nutritional Muscular Dystrophy in Young Rats , Am. J. Path. 15:179, 1939. 30. Barrie, M. M. O.: Vitamin E Deficiency in the Suckling Rat , Nature , London 142:799, 1938. 31. Verzàr, F.: Der Kreatin-Stoffwechsel bei der Muskeldystrophie durch E Vitamin-Mangel und seine Beeinflussung durch Tocopherol , Ztschr. f. Vitaminforsch. 9:242, 1939. 32. Demole, V., and Pfalz, H.: Neuromuskuläre Schädigungen von Jungtieren E- hypovitaminische Ratten, und ihre Behandlung mit synthetische Vitamin E . Schweiz. med. Wchnschr. 69:123, 1939. 33. Telford, I. R.; Emerson, G. A., and Evans, H. M.: Histological Changes in Skeletal Musculature of Paralysed Suckling Young of E-Low Rats , Proc. Soc. Exper. Biol. & Med. 41:291, 1939. 34. Einarson, L., and Ringsted, A.: Effect of Chronic Vitamin E Deficiency on the Nervous System and the Skeletal Musculature in Adult Rats , London. Oxford University Press, 1938. 35. Ringsted, A.: A Preliminary Note on the Appearance of Paresis in Adult Rats Suffering from Chronic Avitaminosis E , Biochem. J. 29:788, 1935. 36. Monnier, M.: Les altérations du systéme nerveux et des muscles striées chez le rat adulte carencé en vitamin E , Compt. rend. Soc. de phys. et hist. nat. 57:252, 1940. 37. Gutiérrez-Mahoney, W.; Mason, K. E., and Swanson, H.: The Neuropathology of Vitamin E Deficiency in the Rat , Am. J. Physiol. 133:308, 1941. 38. Mahoney.1q 39. Goettsch, M., and Pappenheimer, A. M.: α-Tocopherol Requirement of the Rat for Reproduction in the Female and Prevention of Muscular Dystrophy in the Young , J. Nutrition 22:463, 1941. 40. It is interesting that Einarson and Ringsted found that the disease developed less rapidly when oxidized lard was given. It has been the general experience that a diet with a high lard content favors the destruction of vitamin E. 41. De Gutierrez-Mahoney and associates used the Wesson modification of the Osborne-Mendel salt mixture, and Goettsch and Pappenheimer, the Hawk-Oser mixture. 42. Jakob, A.: Normale und pathologische Anatomie und Histologie des Grosshirns , Leipzig, Franz Deuticke, 1927. 43. Gurewitsch, M., and Bychowsky, G.: Zur Architektonik der Hirnrinde (Isocortex) des Hundes , J. f. Psychol. u. Neurol. 35:283, 1928. 44. Mettler, F. A.: Stain Technol. 7:95, 1932. 45. Ranson, S. W.: The Fasciculus Cerebrospinalis in the Albino Rat , Am. J. Anat. 14:411, 1914. 46. Burr, G. O.; Brown, W. R., and Mosely, R. L.: Paralysis in Old Age in Rats on a Diet Deficient in Vitamin E , Proc. Soc. Exper. Biol. & Med. 36:780, 1937. 47. Evans, H. M.; Emerson, G. A., and Telford, I. R.: Degeneration of Cross Striated Musculature in Vitamin E-Low Rats , Proc. Soc. Exper. Biol. & Med. 38:625, 1938. 48. Knowlton, G. C., and Hines, H. M.: Effect of Vitamin E Deficient Diet upon Skeletal Muscle , Proc. Soc. Exper. Biol. & Med. 38:665, 1938.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Oct 1, 1942

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month