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Central Corneal Thickness in Normal, Glaucomatous, and Ocular Hypertensive Eyes

Central Corneal Thickness in Normal, Glaucomatous, and Ocular Hypertensive Eyes Abstract Objective: To determine the relationship between central corneal thickness (CCT) and applanation intraocular pressure (IOP) in normal, glaucomatous, and ocular hypertensive eyes. Methods: One hundred nine subjects (184 eyes) were studied. Forty-eight patients (74 eyes) had glaucoma, 28 patients (51 eyes) had ocular hypertension, and 33 patients (59 eyes) were normal. Intraocular pressure as measured by applanation tonometry, refractive status, CCT, and axial length were measured for all subjects. Results: The CCT (mean±SD) of eyes with ocular hypertension was significantly greater (0.606±0.041 mm) than that of glaucomatous eyes (0.554±0.022 mm) (P<.001) or of normal controls (0.561±0.026 mm) (P<.001). There was no significant difference in CCT between normal and glaucomatous eyes (P=.40). The axial length (mean±SD) of eyes with ocular hypertension (23.54±1.34 mm) was not different compared with glaucomatous eyes (23.93±0.96 mm) (P=.13) or normal eyes (23.62±1.21 mm) (P=.83). There was no significant difference between the axial length for glaucomatous eyes compared with normal eyes (P=.18). Those eyes with glaucoma being treated with topical dorzolamide hydrochloride had a significantly increased CCT (0.560±0.025 mm) compared with those eyes with glaucoma not being treated with dorzolamide (0.551±0.20 mm) (P=.02). Conclusions: The mean CCT is increased in eyes with ocular hypertension when compared with normal or glaucomatous eyes, which confirms the findings of other investigators. Increased CCT may give an artificially high IOP measurement by applanation tonometry. The CCT must be considered when developing a treatment approach for patients with ocular hypertension. References 1. Drance SM. The coefficient of scleral rigidity in normal and glaucomatous eyes . Arch Ophthalmol . 1960;63:668-674.Crossref 2. Goldmann H, Schmidt T. Uber applanationstonometrie . Ophthalmologica . 1957;134:221-242.Crossref 3. Hansen FK, Ehlers N. Elevated tonometer readings caused by a thick cornea . Acta Ophthalmol . 1971;49:775-778.Crossref 4. Ehlers N, Bramsen T, Sperling S. Applanation tonometry and central corneal thickness . Acta Ophthalmol . 1975;53:34-43.Crossref 5. Whitacre MM, Stein RA, Hassanein K. The effect of corneal thickness on applanation tonometry . Am J Ophthalmol . 1993;115:592-596. 6. Epstein DL, Krug JH, Hertzmark E, Remis LL, Edelstein DJ. A long-term clinical trial of timolol therapy versus no treatment in the management of glaucoma suspects . Ophthalmology . 1989;96:1460-1467.Crossref 7. Kass MA. Timolol treatment prevents or delays glaucomatous visual field loss in individuals with ocular hypertension: a five-year, randomized, double-masked, clinical trial . Trans Am Ophthalmol Soc . 1989;87:598-609. 8. Ehlers N, Hansen FK, Aasved H. Biometric correlations of corneal thickness . Acta Ophthalmol . 1975;53:652-659.Crossref 9. Johnson M, Kass MA, Moses RA, Grodzki WJ. Increased corneal thickness simulating elevated intraocular pressure . Arch Ophthalmol . 1978;96:664-665.Crossref 10. Argus WA. Ocular hypertension and central corneal thickness . Ophthalmology . 1995;102:1810-1812.Crossref 11. Little RC, Milliken GA, Stroup WW, Wolfinger RD. SAS System for Mixed Models . Cary, NC: SAS Institute Inc; 1996. 12. Goldmann H. Applanation tonometry . In: Newell FW, eds. Glaucoma: Transactions of the Second Conference . New York, NY: Josiah Macy, Jr, Foundation; 1957:167-220. 13. Hansen FK. A clinical study of the normal human central corneal thickness . Acta Ophthalmol . 1971;49:82-88. 14. Siu A, Herse P. The effect of age on human corneal thickness . Acta Ophthalmol . 1993;71:51-56.Crossref 15. Simon G, Small RH, Ren Q, Parel JM. Effect of corneal hydration on Goldmann applanation tonometry and corneal topography . Refractive Corneal Surg . 1993;9:110-117. 16. Wilkerson M, Cyrlin M, Lippa EA, et al. Four-week safety and efficacy study of dorzolamide, a novel, active topical carbonic anhydrase inhibitor . Arch Ophthalmol . 1993;111:1343-1350.Crossref 17. Wang YL, Zhan GL, Toris CB, Yablonski ME. Fluorophotometric study of acetazolamide inhibition of fluid transport across cat corneal endothelium in vivo . Invest Ophthalmol Vis Sci . 1995;36:1385. Abstract. 18. Ehlers N. On corneal thickness and intraocular pressure, II: a clinical study on the thickness of the corneal stroma in glaucomatous eyes . Acta Ophthalmol . 1970;48:1107-1112.Crossref 19. Schipper I, Senn P, Niesen U. Are we measuring the right intraocular pressure after excimer laser photorefractive laser keratoplasty in myopia? Klinische Monatsbl Augenheilkd . 1995;206:322-324.Crossref 20. Chatterjee A, Shah S, Bessant DA, Naroo SA, Doyle SJ. Reduction in intraocular pressure after excimer laser photorefractive keratectomy: correlation with pretreatment myopia . Ophthalmology . 1997;104:355-359.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Central Corneal Thickness in Normal, Glaucomatous, and Ocular Hypertensive Eyes

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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1997.01100160307007
Publisher site
See Article on Publisher Site

Abstract

Abstract Objective: To determine the relationship between central corneal thickness (CCT) and applanation intraocular pressure (IOP) in normal, glaucomatous, and ocular hypertensive eyes. Methods: One hundred nine subjects (184 eyes) were studied. Forty-eight patients (74 eyes) had glaucoma, 28 patients (51 eyes) had ocular hypertension, and 33 patients (59 eyes) were normal. Intraocular pressure as measured by applanation tonometry, refractive status, CCT, and axial length were measured for all subjects. Results: The CCT (mean±SD) of eyes with ocular hypertension was significantly greater (0.606±0.041 mm) than that of glaucomatous eyes (0.554±0.022 mm) (P<.001) or of normal controls (0.561±0.026 mm) (P<.001). There was no significant difference in CCT between normal and glaucomatous eyes (P=.40). The axial length (mean±SD) of eyes with ocular hypertension (23.54±1.34 mm) was not different compared with glaucomatous eyes (23.93±0.96 mm) (P=.13) or normal eyes (23.62±1.21 mm) (P=.83). There was no significant difference between the axial length for glaucomatous eyes compared with normal eyes (P=.18). Those eyes with glaucoma being treated with topical dorzolamide hydrochloride had a significantly increased CCT (0.560±0.025 mm) compared with those eyes with glaucoma not being treated with dorzolamide (0.551±0.20 mm) (P=.02). Conclusions: The mean CCT is increased in eyes with ocular hypertension when compared with normal or glaucomatous eyes, which confirms the findings of other investigators. Increased CCT may give an artificially high IOP measurement by applanation tonometry. The CCT must be considered when developing a treatment approach for patients with ocular hypertension. References 1. Drance SM. The coefficient of scleral rigidity in normal and glaucomatous eyes . Arch Ophthalmol . 1960;63:668-674.Crossref 2. Goldmann H, Schmidt T. Uber applanationstonometrie . Ophthalmologica . 1957;134:221-242.Crossref 3. Hansen FK, Ehlers N. Elevated tonometer readings caused by a thick cornea . Acta Ophthalmol . 1971;49:775-778.Crossref 4. Ehlers N, Bramsen T, Sperling S. Applanation tonometry and central corneal thickness . Acta Ophthalmol . 1975;53:34-43.Crossref 5. Whitacre MM, Stein RA, Hassanein K. The effect of corneal thickness on applanation tonometry . Am J Ophthalmol . 1993;115:592-596. 6. Epstein DL, Krug JH, Hertzmark E, Remis LL, Edelstein DJ. A long-term clinical trial of timolol therapy versus no treatment in the management of glaucoma suspects . Ophthalmology . 1989;96:1460-1467.Crossref 7. Kass MA. Timolol treatment prevents or delays glaucomatous visual field loss in individuals with ocular hypertension: a five-year, randomized, double-masked, clinical trial . Trans Am Ophthalmol Soc . 1989;87:598-609. 8. Ehlers N, Hansen FK, Aasved H. Biometric correlations of corneal thickness . Acta Ophthalmol . 1975;53:652-659.Crossref 9. Johnson M, Kass MA, Moses RA, Grodzki WJ. Increased corneal thickness simulating elevated intraocular pressure . Arch Ophthalmol . 1978;96:664-665.Crossref 10. Argus WA. Ocular hypertension and central corneal thickness . Ophthalmology . 1995;102:1810-1812.Crossref 11. Little RC, Milliken GA, Stroup WW, Wolfinger RD. SAS System for Mixed Models . Cary, NC: SAS Institute Inc; 1996. 12. Goldmann H. Applanation tonometry . In: Newell FW, eds. Glaucoma: Transactions of the Second Conference . New York, NY: Josiah Macy, Jr, Foundation; 1957:167-220. 13. Hansen FK. A clinical study of the normal human central corneal thickness . Acta Ophthalmol . 1971;49:82-88. 14. Siu A, Herse P. The effect of age on human corneal thickness . Acta Ophthalmol . 1993;71:51-56.Crossref 15. Simon G, Small RH, Ren Q, Parel JM. Effect of corneal hydration on Goldmann applanation tonometry and corneal topography . Refractive Corneal Surg . 1993;9:110-117. 16. Wilkerson M, Cyrlin M, Lippa EA, et al. Four-week safety and efficacy study of dorzolamide, a novel, active topical carbonic anhydrase inhibitor . Arch Ophthalmol . 1993;111:1343-1350.Crossref 17. Wang YL, Zhan GL, Toris CB, Yablonski ME. Fluorophotometric study of acetazolamide inhibition of fluid transport across cat corneal endothelium in vivo . Invest Ophthalmol Vis Sci . 1995;36:1385. Abstract. 18. Ehlers N. On corneal thickness and intraocular pressure, II: a clinical study on the thickness of the corneal stroma in glaucomatous eyes . Acta Ophthalmol . 1970;48:1107-1112.Crossref 19. Schipper I, Senn P, Niesen U. Are we measuring the right intraocular pressure after excimer laser photorefractive laser keratoplasty in myopia? Klinische Monatsbl Augenheilkd . 1995;206:322-324.Crossref 20. Chatterjee A, Shah S, Bessant DA, Naroo SA, Doyle SJ. Reduction in intraocular pressure after excimer laser photorefractive keratectomy: correlation with pretreatment myopia . Ophthalmology . 1997;104:355-359.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1997

References