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Cell Production and Migration in the Epithelial Layer of the Lens

Cell Production and Migration in the Epithelial Layer of the Lens Abstract The epithelial layer of the lens has been implicated in the pathogenesis of several types of cataract.1 These types, which are progressive, slow to develop, and usually nonreversible, include various radiation cataracts such as those caused by ultraviolet, infrared, x-ray, γ-ray, neutron, β-ray, and radiomimetic agents such as busulfan (Myleran).* In a number of animal experiments where the germinative zone of the lens epithelium was selectively irradiated a slow forming opacity was found, whereas selective irradiation in other areas of the lens required much larger doses to produce the same effect.2-4 These results give strong support to the idea that the lens epithelial cells, especially those cells of the proliferative zone, are directly involved in the developing opacity. The sequence of postulated events leading to the formation of radiation cataracts as first suggested by Rohrschneider2 and outlined in a book by Duke-Elder5 are as follows: "The References 1. 1,4-Dimethyanesulfonoxybutane. 2. von Sallmann, L.: The Lens Epithelium in the Pathogenesis of Cataract , Amer. J. Ophthal. 44: 159, 1957. 3. Rohrschneider, W.: Experimentelle Erzeugung von Röntgenstrahlenkatarakt , Strahlentherapie 31:596, 1929 4. Experimentelle Untersuchungen über die Veränderungen normaler Augengewebe nach Röntgenbestrahlung: Veränderungen der Linse, der Natzhaut und des Sehnerven nach Röntgenbestrahlung , Arch. f. Ophthal. 122:282, 1929 5. Über die Wirkung der Röntgenstraheln auf das Auge , Strahlentherapie 38:665, 1930. 6. Alter, A. J., and Leinfelder, P. J.: Roentgen-Ray Cataract: Effects of Shielding of the Lens and Ciliary Body , A.M.A. Arch. Ophthal. 49:257, 1953.Crossref 7. Pirie, A., and Flanders, P. H.: Effect of X-Rays on Partially Shielded Lens of the Rabbit , A.M.A. Arch. Ophthal. 57:854, 1957.Crossref 8. Duke-Elder, S.: Text-Book of Ophthalmology , Vol. 6, The C. V. Mosby Company, 1954, p. 6557. 9. Cogan, D. G., and Donaldson, D. D.: Experimental Radiation Cataracts: I. Cataracts in the Rabbit Following Single X-Ray Exposure , A.M.A. Arch. Ophthal. 45:508, 1951.Crossref 10. Leinfelder, P. J., and Kerr, H. D.: Roentgen-Ray Cataract: An Experimental, Clinical and Microscopic Study , Amer. J. Ophthal. 19:739, 1936. 11. Hanna, C., and O'Brien, J. E.: Studies on Galactose Cataract Formation Utilizing Thymidine-Tritium , Arch. Ophthal. 64:708, 1960.Crossref 12. Hanna, C., and O'Brien, J. E.: Cell Production and Migration in the Epithelial Layer of the Cornea , Arch. Ophthal. 64:536, 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Cell Production and Migration in the Epithelial Layer of the Lens

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1961.00960010105023
Publisher site
See Article on Publisher Site

Abstract

Abstract The epithelial layer of the lens has been implicated in the pathogenesis of several types of cataract.1 These types, which are progressive, slow to develop, and usually nonreversible, include various radiation cataracts such as those caused by ultraviolet, infrared, x-ray, γ-ray, neutron, β-ray, and radiomimetic agents such as busulfan (Myleran).* In a number of animal experiments where the germinative zone of the lens epithelium was selectively irradiated a slow forming opacity was found, whereas selective irradiation in other areas of the lens required much larger doses to produce the same effect.2-4 These results give strong support to the idea that the lens epithelial cells, especially those cells of the proliferative zone, are directly involved in the developing opacity. The sequence of postulated events leading to the formation of radiation cataracts as first suggested by Rohrschneider2 and outlined in a book by Duke-Elder5 are as follows: "The References 1. 1,4-Dimethyanesulfonoxybutane. 2. von Sallmann, L.: The Lens Epithelium in the Pathogenesis of Cataract , Amer. J. Ophthal. 44: 159, 1957. 3. Rohrschneider, W.: Experimentelle Erzeugung von Röntgenstrahlenkatarakt , Strahlentherapie 31:596, 1929 4. Experimentelle Untersuchungen über die Veränderungen normaler Augengewebe nach Röntgenbestrahlung: Veränderungen der Linse, der Natzhaut und des Sehnerven nach Röntgenbestrahlung , Arch. f. Ophthal. 122:282, 1929 5. Über die Wirkung der Röntgenstraheln auf das Auge , Strahlentherapie 38:665, 1930. 6. Alter, A. J., and Leinfelder, P. J.: Roentgen-Ray Cataract: Effects of Shielding of the Lens and Ciliary Body , A.M.A. Arch. Ophthal. 49:257, 1953.Crossref 7. Pirie, A., and Flanders, P. H.: Effect of X-Rays on Partially Shielded Lens of the Rabbit , A.M.A. Arch. Ophthal. 57:854, 1957.Crossref 8. Duke-Elder, S.: Text-Book of Ophthalmology , Vol. 6, The C. V. Mosby Company, 1954, p. 6557. 9. Cogan, D. G., and Donaldson, D. D.: Experimental Radiation Cataracts: I. Cataracts in the Rabbit Following Single X-Ray Exposure , A.M.A. Arch. Ophthal. 45:508, 1951.Crossref 10. Leinfelder, P. J., and Kerr, H. D.: Roentgen-Ray Cataract: An Experimental, Clinical and Microscopic Study , Amer. J. Ophthal. 19:739, 1936. 11. Hanna, C., and O'Brien, J. E.: Studies on Galactose Cataract Formation Utilizing Thymidine-Tritium , Arch. Ophthal. 64:708, 1960.Crossref 12. Hanna, C., and O'Brien, J. E.: Cell Production and Migration in the Epithelial Layer of the Cornea , Arch. Ophthal. 64:536, 1960.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1961

References