Opinion EDITORIAL David J. Kerr, MD, DSc; Sarah Chamberlain, BMedSci, MBChB; Rachel S. Kerr, MBChB, PhD Observational studies have linked aspirin and selective ing that perhaps if there is a small beneficial effect, this cyclooxygenase-2 (COX-2) inhibitors to prevention of colorec- occurs early and is maintained. Assuming the reported esti- tal adenomas and colorectal cancer, and reduction in recur- mated difference in disease-free survival and overall survival rates reported (2.9%) could be repeated in a larger trial, with rence following resection or improved survival for patients with advanced or metastatic statistical certainty, it is possible this observation may trans- 1-3 disease. There are plau- late to a clinically acceptable patient benefit. Related article page 1277 sible mechanistic hypoth- Second, the authors highlight that the original statistical eses linking inhibition of prostaglandin synthesis, nuclear assumptions of the trial assumed more rapid enrollment and 4 5 factor κB activation, and the transcription factor RUNX1 to more events than were achieved. This is a common occur- the anticancer effects of aspirin and celecoxib. In addition, rence in contemporary randomized adjuvant therapy trials there is evidence from a meta-analysis across multiple stud- globally. Both groups (treatment and placebo) generally expe- ies of the
JAMA – American Medical Association
Published: Apr 6, 2021
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera