Access the full text.
Sign up today, get DeepDyve free for 14 days.
Maria Rio, G. McCracken, John Nelson, D. Chrane, S. Shelton (1982)
Pharmacokinetics and cerebrospinal fluid bactericidal activity of ceftriaxone in the treatment of pediatric patients with bacterial meningitisAntimicrobial Agents and Chemotherapy, 22
J. Gnann, W. Goetter, A. Elliott, C. Cobbs (1982)
Ceftriaxone: in vitro studies and clinical evaluationAntimicrobial Agents and Chemotherapy, 22
R. Steele, Linda Eyre, R. Bradsher, R. Weinfeld, I. Patel, J. Spicehandler (1983)
Pharmacokinetics of Ceftriaxone in Pediatric Patients With MeningitisAntimicrobial Agents and Chemotherapy, 23
I. Patel, S. Chen, M. Parsonnet, M. Hackman, M. Brooks, J. Konikoff, S. Kaplan (1981)
Pharmacokinetics of ceftriaxone in humansAntimicrobial Agents and Chemotherapy, 20
R. Bradsher (1982)
Ceftriaxone (Ro 13-9904) therapy of serious infectionAntimicrobial Agents and Chemotherapy, 22
T. Eickhoff, J. Ehret (1981)
Comparative in vitro studies of Ro 13-9904, a new cephalosporin derivativeAntimicrobial Agents and Chemotherapy, 19
Barry AL Gavan TL (1980)
Manual for Clinical Microbiology
J. Bennett, J. Brodie, E. Benner, W. Kirby (1966)
Simplified, accurate method for antibiotic assay of clinical specimens.Applied microbiology, 14 2
Abstract • Ceftriaxone Is an investigational cephalosporin with a half-life of five to eight hours. In an uncontrolled study, we evaluated its efficacy and safety In 30 pediatric and 12 young adult patients with serious bacterial infections. This agent was administered to children at a dosage of 50 to 75 mg/kg/day intravenously in two divided doses. Those with CNS infections received 100 mg/kg/day. In adults, the dosage was 1 g either once or twice daily. The diseases we treated included pneumonia (17), sepsis (eight), ventriculoperitoneal shunt infections (three), osteomyelitis (three), brain abscess (two), peritonitis (two), and miscellaneous (seven). Clinical cures were achieved in all cases, although one child with cystic fibrosis and Pseudomonas pneumonia had persistent colonization in his sputum. No serious side effects were observed. Although not the agent of choice for many of these pathogens, ceftriaxone appears to represent an important alternative to therapy. (Am J Dis Child 1983;137:1044-1047) References 1. Eickhoff TC, Ehret J: Comparative in vitro studies of RO13-9904, a new cephalosporin derivative . Antimicrob Agents Chemother 1981;19: 435-442.Crossref 2. Steele RW, Eyre LB, Bradsher RW, et al: Pharmacokinetics of ceftriaxone in pediatric patients with meningitis . Antimicrob Agents Chemother 1983;23:191-194.Crossref 3. Bradsher RW: Ceftriaxone (RO 13-9904) therapy of serious infections . Antimicrob Agents Chemother 1982;22:36-42.Crossref 4. Steele RW, Bradsher RW: A comparison of ceftriaxone to standard therapy for bacterial meningitis. J Pediatr, in press. 5. Gnann JW Jr, Goetter WE, Elliott AM, et al: Ceftriaxone: In vitro studies and clinical evaluations . Antimicrob Agents Chemother 1982;22: 1-9.Crossref 6. Gavan TL, Barry AL: Microdilution test procedures , in Lennette EH, Balows A, Hausler WJ Jr, et al (eds): Manual for Clinical Microbiology . Washington, DC, American Society for Microbiology, 1980. 7. Patel IH, Chen S, Parsonnet M, et al: Pharmacokinetics of ceftriaxone in humans . Antimicrob Agents Chemother 1981;20:634-641.Crossref 8. Bennett JV, Brodie EJ, Benner EJ, et al: Simplified, accurate method for antibiotic assay of clinical specimens . Appl Microbiol 1966;14: 170-177. 9. Bradsher RW, Ulmer WC: β-Lactam antibiotic susceptibility of bacteria responsible for neonatal meningitis. Chemotherapy, in press. 10. Del Rio M, McCracken GH Jr, Nelson JD, et al: Pharmacokinetics and cerebrospinal fluid bactericidal activity of ceftriaxone in the treatment of pediatric patients with bacterial meningitis . Antimicrob Agents Chemother 1982;22: 622-627.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Nov 1, 1983
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.