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EDITORIAL Case-Control Designs for Clinical Research in Ophthalmology UBLICATIONS FROM the Eye Disease Case- of the cohorts would be prohibitive if the goal of the study Control Study Group during the past 5 were to estimate the risk of certain rare conditions (eg, 1-6 years have focused attention on the case- uveal melanoma). An example of the use of both de- control design for clinical research in oph- signs in a complementary way is the case-control study P thalmology. However, case-control studies of ocular histoplasmosis conducted by Ganley in 1970 of eye and vision disorders did not originate with the Eye and the subsequent follow-up study of the case and con- Disease Case-Control Study Group. Reports from case- trol groups for loss of visual acuity conducted by Hawk- control studies of varying size and quality have been pub- ins and Ganley in 1985. Another is the Longitudinal lished in the ophthalmologic and epidemiologic litera- Study of Cataract, which followed up participants in the 7-18 19 ture for more than 30 years. As noted by Seigel in earlier Lens Opacities Case-Control Study. Another commonly reported type of study, the cross- an editorial published in the ARCHIVES almost 10 years sectional
JAMA Ophthalmology – American Medical Association
Published: May 1, 1998
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