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Cartilage Speeds Healing in Diabetic Wounds

Cartilage Speeds Healing in Diabetic Wounds Abstract Prudden and his collaborators have consistently shown an acceleration of wound healing in normal rats by the topical application of digested bovine cartilage powder, or by the subcutaneous implantation of cartilage pellets at a distance from the wound.9 Prior work in our laboratory has shown that the healing of sutured incised wounds is impaired in animals with alloxan diabetes, and that this impairment may be partially or completely corrected by adequate control of the diabetic state.11,12 It seemed appropriate, therefore, to determine whether or not locally applied bovine cartilage powder would correct the healing defect in poorly controlled diabetic animals. Methods Male albino Wistar rats weighing from 150 to 200 gm were used. The normal blood sugar values in this strain range from 65 to 120 mg%. Diabetes was induced in animals which had been fasting for 48 hours by intraperitoneal injection of alloxan (150 mg/kg), one hour References 1. Forscher, B. K., and Cecil, H. C.: Biochemical Studies of Acute Inflammation , Arch Biochem 70:367, 1957.Crossref 2. Greene, J. A.; Swanson, L. W.; and Jacobs, C. A.: Control of Diabetes Mellitus: Relation to the Healing of Clean and Infected Wounds and to Incidences of Infection in Clean Wounds , JAMA 115:1518, 1940.Crossref 3. Houck, J. C., and Vickers, K.: The Inhibition of Inflammation and the Acceleration of Tissue Repair by Cartilage Powder , Surgery 51:632, 1962. 4. Inoue, T.: The "Cartilage Effect" on Healing Wounds: A Study of the Specificity of the Phenomenon , Arch Surg 82:432, 1961.Crossref 5. Lattes, R.; Martin, J. R.; Meyer, K.; and Ragan, C.: Effect of Cartilage and Other Suspensions on Reparative Process of Cortisone Treated Animals , Amer J Path 32:979, 1956. 6. Paulette, R. E., and Prudden, J. E.: Studies on the Acceleration of Wound Healing With Cartilage: II. Histologic Observations , Surg Gynec Obstet 108:406, 1958. 7. Prudden, J. F.; Nishihara, G.; and Baker, L.: The Acceleration of Wound Healing With Cartilage , Surg Gynec Obset 105:283, 1957. 8. Prudden, J. F.: The Stimulation of Wound Healing With Heterologous Cartilage , Transplant Bull 5:14, 1958.Crossref 9. Prudden, J. F.; Inoue, T.; and Ocampo, L.: Subcutaneous Cartilage Pellets , Arch Surg 85:245, 1962.Crossref 10. Prudden, J. F.; Gabriel, O.; and Allen, B.: The Acceleration of Wound Healing , Arch Surg 86:157, 1963.Crossref 11. Rosen, R. G., and Enquist, I. F.: The Healing Wound in Experimental Diabetes , Surgery 50: 525, 1961. 12. Rosenthal, S.; Lerner, B.; DiBiase, F.; and Enquist, I. F.: Relation of Strength to Composition in Diabetic Wounds , Surg Gynec Obstet 115:437, 1962. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Cartilage Speeds Healing in Diabetic Wounds

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1963.01310160109021
Publisher site
See Article on Publisher Site

Abstract

Abstract Prudden and his collaborators have consistently shown an acceleration of wound healing in normal rats by the topical application of digested bovine cartilage powder, or by the subcutaneous implantation of cartilage pellets at a distance from the wound.9 Prior work in our laboratory has shown that the healing of sutured incised wounds is impaired in animals with alloxan diabetes, and that this impairment may be partially or completely corrected by adequate control of the diabetic state.11,12 It seemed appropriate, therefore, to determine whether or not locally applied bovine cartilage powder would correct the healing defect in poorly controlled diabetic animals. Methods Male albino Wistar rats weighing from 150 to 200 gm were used. The normal blood sugar values in this strain range from 65 to 120 mg%. Diabetes was induced in animals which had been fasting for 48 hours by intraperitoneal injection of alloxan (150 mg/kg), one hour References 1. Forscher, B. K., and Cecil, H. C.: Biochemical Studies of Acute Inflammation , Arch Biochem 70:367, 1957.Crossref 2. Greene, J. A.; Swanson, L. W.; and Jacobs, C. A.: Control of Diabetes Mellitus: Relation to the Healing of Clean and Infected Wounds and to Incidences of Infection in Clean Wounds , JAMA 115:1518, 1940.Crossref 3. Houck, J. C., and Vickers, K.: The Inhibition of Inflammation and the Acceleration of Tissue Repair by Cartilage Powder , Surgery 51:632, 1962. 4. Inoue, T.: The "Cartilage Effect" on Healing Wounds: A Study of the Specificity of the Phenomenon , Arch Surg 82:432, 1961.Crossref 5. Lattes, R.; Martin, J. R.; Meyer, K.; and Ragan, C.: Effect of Cartilage and Other Suspensions on Reparative Process of Cortisone Treated Animals , Amer J Path 32:979, 1956. 6. Paulette, R. E., and Prudden, J. E.: Studies on the Acceleration of Wound Healing With Cartilage: II. Histologic Observations , Surg Gynec Obstet 108:406, 1958. 7. Prudden, J. F.; Nishihara, G.; and Baker, L.: The Acceleration of Wound Healing With Cartilage , Surg Gynec Obset 105:283, 1957. 8. Prudden, J. F.: The Stimulation of Wound Healing With Heterologous Cartilage , Transplant Bull 5:14, 1958.Crossref 9. Prudden, J. F.; Inoue, T.; and Ocampo, L.: Subcutaneous Cartilage Pellets , Arch Surg 85:245, 1962.Crossref 10. Prudden, J. F.; Gabriel, O.; and Allen, B.: The Acceleration of Wound Healing , Arch Surg 86:157, 1963.Crossref 11. Rosen, R. G., and Enquist, I. F.: The Healing Wound in Experimental Diabetes , Surgery 50: 525, 1961. 12. Rosenthal, S.; Lerner, B.; DiBiase, F.; and Enquist, I. F.: Relation of Strength to Composition in Diabetic Wounds , Surg Gynec Obstet 115:437, 1962.

Journal

Archives of SurgeryAmerican Medical Association

Published: Oct 1, 1963

References