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CARDIOVASCULAR DISEASE AS A COMPLICATION OF GENERALIZED NEUROFIBROMATOSIS

CARDIOVASCULAR DISEASE AS A COMPLICATION OF GENERALIZED NEUROFIBROMATOSIS Abstract The possibility of cardiovascular disease as a result of vagus and sympathetic involvement is not an original idea of ours, but there are no cases reported in the literature in which the authors considered this possibility seriously. At necropsy the vagi and sympathetics are frequently found to be involved by neurofibromas in patients that during life had been afflicted with von Recklinghausen's disease. The most extensive postmortem studies of generalized neurofibromatosis show that the vagi are the most frequent of the cranial nerves to be involved, but when involved the tumors are usually outside the dura. Céstan states that involvement by neurofirbomas could cause death by tachycardia, vomiting, difficulty in swallowing and consequent aspiration pneumonia. Healy's1 case, which showed tachycardia (90-120), a high grade optic neuritis with a mottled paleness in the center of the exudate and the insensitive cornea is the nearest counterpart to case 1 (which report References 1. Healy, W.: Peripheral and Intracranial Neurofibromatosis , J. A. M. A. 52:945-947 ( (March 20) ), 1909.Crossref 2. Smith, R. W.: A Treatise on the Pathology , Diagnosis and Treatment of Neuroma , Dublin, 1849. 3. Virchow: Die Krankhaften Geschwulste, 1863. 4. Von Recklinghausen: Ueber die multiplen Fibrome der Haut und ihre Beziehung zu den Multiplen Neuromen , Berlin, 1882. 5. Feindel and Oppenheim: Sur les formes incomplete de la neurofibromatose , Arch. gen. de méd. 2:77, 1898. 6. Adrian, C., and Hugel, G.: Des formes abortive de la maladie de Recklinghausen , Ann. de dermat. et syph. 7:152, 1918-1919. 7. Scholl, O. K.: Abortive Forms of Recklinghausen's Disease , Strassberg, 1916. 8. Groin, K.: Forme Fruste of Recklinghausen's Disease , Brit. J. Dermat. 35:362,N 1923. 9. Weber, Parkes: Cutaneous Pigmentation as an Incomplete Form of Von Recklinghausen's Disease , Brit. J. Dermat. 21:49, 1909. 10. Brickner: Fibroma Molluscum Gravidarum , Am. J. Obst. 53:191-199, 1906. 11. Sutton: A Clinical Note on Fibroma Molluscum Gravidarum , Am. J. Med. Soc. 147:419-423, 1914.Crossref 12. Abbott and Shattock: Neurofibromatosis of the Nerves of the Tongue , Ann. Surg. 37, (March) , 1903. 13. Aubineau and Civel: Tumeur palpebrale et paralysie de la VI paire dans un maladie de Recklinghausen , Arch. d. oph. 31:808-815, 1911. 14. Benaky: Neurofibromatose generalisse avec molluscum pendulum de la moitre droite de la face et ptosis de l'orellie , Ann. de dermat. et syph. 5:977-982, 1904. 15. Harbitz, F.: Multiple Neurofibromatosis , Arch. Int. Med. 3:32 ( (Feb.) ) 1909.Crossref 16. Unna: Histopathology of the Diseases of the Skin , New York, The Macmillan Company, 1896, pp. 843-848. 17. Christin and Naville: A propos de neurofibromatoses centrale leurs formes familiales et hereditaires; les neurofibrom des nerfs optique cas a evolution antypique diversite des structures histologique , Ann. méd. 8:30, 1920. 18. Unna: Histopathology, Pringle , Edinburgh M. J. 49:260, 1900. 19. Kriege: On the Relation of the Nerve Fibers in Multiple Fibromata, of the Skin and in Neuromata , Virchows Arch. f. path Anat. 108:143, 1887.Crossref 20. Crocker: Diseases of the Skin , Philadelphia, P. Blakiston's Son & Co. 2: 948, 1908. 21. Rolleston, H. D.: A Case of Von Recklinghausen's Disease with a Sarcomatous Growth Involving the Brachial Plexus , Lancet , (July) , 1889, p. 271. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

CARDIOVASCULAR DISEASE AS A COMPLICATION OF GENERALIZED NEUROFIBROMATOSIS

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Publisher
American Medical Association
Copyright
Copyright © 1926 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1926.02370180071005
Publisher site
See Article on Publisher Site

Abstract

Abstract The possibility of cardiovascular disease as a result of vagus and sympathetic involvement is not an original idea of ours, but there are no cases reported in the literature in which the authors considered this possibility seriously. At necropsy the vagi and sympathetics are frequently found to be involved by neurofibromas in patients that during life had been afflicted with von Recklinghausen's disease. The most extensive postmortem studies of generalized neurofibromatosis show that the vagi are the most frequent of the cranial nerves to be involved, but when involved the tumors are usually outside the dura. Céstan states that involvement by neurofirbomas could cause death by tachycardia, vomiting, difficulty in swallowing and consequent aspiration pneumonia. Healy's1 case, which showed tachycardia (90-120), a high grade optic neuritis with a mottled paleness in the center of the exudate and the insensitive cornea is the nearest counterpart to case 1 (which report References 1. Healy, W.: Peripheral and Intracranial Neurofibromatosis , J. A. M. A. 52:945-947 ( (March 20) ), 1909.Crossref 2. Smith, R. W.: A Treatise on the Pathology , Diagnosis and Treatment of Neuroma , Dublin, 1849. 3. Virchow: Die Krankhaften Geschwulste, 1863. 4. Von Recklinghausen: Ueber die multiplen Fibrome der Haut und ihre Beziehung zu den Multiplen Neuromen , Berlin, 1882. 5. Feindel and Oppenheim: Sur les formes incomplete de la neurofibromatose , Arch. gen. de méd. 2:77, 1898. 6. Adrian, C., and Hugel, G.: Des formes abortive de la maladie de Recklinghausen , Ann. de dermat. et syph. 7:152, 1918-1919. 7. Scholl, O. K.: Abortive Forms of Recklinghausen's Disease , Strassberg, 1916. 8. Groin, K.: Forme Fruste of Recklinghausen's Disease , Brit. J. Dermat. 35:362,N 1923. 9. Weber, Parkes: Cutaneous Pigmentation as an Incomplete Form of Von Recklinghausen's Disease , Brit. J. Dermat. 21:49, 1909. 10. Brickner: Fibroma Molluscum Gravidarum , Am. J. Obst. 53:191-199, 1906. 11. Sutton: A Clinical Note on Fibroma Molluscum Gravidarum , Am. J. Med. Soc. 147:419-423, 1914.Crossref 12. Abbott and Shattock: Neurofibromatosis of the Nerves of the Tongue , Ann. Surg. 37, (March) , 1903. 13. Aubineau and Civel: Tumeur palpebrale et paralysie de la VI paire dans un maladie de Recklinghausen , Arch. d. oph. 31:808-815, 1911. 14. Benaky: Neurofibromatose generalisse avec molluscum pendulum de la moitre droite de la face et ptosis de l'orellie , Ann. de dermat. et syph. 5:977-982, 1904. 15. Harbitz, F.: Multiple Neurofibromatosis , Arch. Int. Med. 3:32 ( (Feb.) ) 1909.Crossref 16. Unna: Histopathology of the Diseases of the Skin , New York, The Macmillan Company, 1896, pp. 843-848. 17. Christin and Naville: A propos de neurofibromatoses centrale leurs formes familiales et hereditaires; les neurofibrom des nerfs optique cas a evolution antypique diversite des structures histologique , Ann. méd. 8:30, 1920. 18. Unna: Histopathology, Pringle , Edinburgh M. J. 49:260, 1900. 19. Kriege: On the Relation of the Nerve Fibers in Multiple Fibromata, of the Skin and in Neuromata , Virchows Arch. f. path Anat. 108:143, 1887.Crossref 20. Crocker: Diseases of the Skin , Philadelphia, P. Blakiston's Son & Co. 2: 948, 1908. 21. Rolleston, H. D.: A Case of Von Recklinghausen's Disease with a Sarcomatous Growth Involving the Brachial Plexus , Lancet , (July) , 1889, p. 271.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Jun 1, 1926

References