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CARDIAZOL: SOME EXPERIMENTAL EFFECTS OF THIS DRUG ON THE CARDIORESPIRATORY MECHANISM

CARDIAZOL: SOME EXPERIMENTAL EFFECTS OF THIS DRUG ON THE CARDIORESPIRATORY MECHANISM Abstract Much has been written of late, especially in the continental medical journals, as to the value of cardiazol (penta-methyl-tetrazol). It has been recommended especially in cases of acute cardiovascular collapse and respiratory failure. Glowing reports are appearing of its use in varied conditions, such as pneumonia, surgical shock, intrapartum asphyxia, auricular fibrillation, angina pectoris, diabetic coma, scopolamine depression and other conditions. The bulk of these reports, however, are of poorly controlled clinical observations made on a small number of cases, usually from three to six, when other stimulants had previously been given. It is our purpose in this paper to give a short summary of the pharmacology of cardiazol and to report some experimental work concerning the points for which it is most recommended. Camphor has long been used as a cardiac stimulant, especially in acute conditions and in moribund states. Lewin,1 in 1890, and Schwalb,2 in 1912, found it References 1. Lewin, A.: Arch. f. exper. Path. u. Pharmakol. 27:226, 1890.Crossref 2. Schwalb, H.: Arch. f. exper. Path. u. Pharmakol. 70:70, 1912.Crossref 3. Joachinoglu, G.: Arch. f. exper. Path. u. Pharmakol. 80:259, 1916.Crossref 4. Heathcote, R. A.: J. Pharm. & Exper. Therap. 21:177 ( (April) ) 1923. 5. Sollmann, T.: A Manual of Pharmacology , Philadelphia, W. B. Saunders Company, 1922, p. 493. 6. Cushney, A. R.: Pharmacology and Therapy , Philadelphia, Lea & Febiger, 1924, p. 72. 7. J. A. M. A. 90:2019 ( (June 23) ) 1928 8. Marvin, H. M., and Soifer, J. D.: Value of Camphor-in-Oil as a Cardiac Stimulant , J. A. M. A. 83:94 ( (July) ) 1924. 9. Wolf and Sherman: Clin. Med. 33:8 ( (Aug.) ) 1926. 10. Schmiederberg and Meyer: Ztschr. f. Phys. Chem. 3:422, 1924. 11. Gottlieb, R., and Schuleman, W.: Deutsche med. Wchnschr. 49:1536 ( (Dec.) ) 1923. 12. Hemmerling: Deutsche med. Wchnschr. 51:1618, 1925. 13. Schmidt, K. F.: Hildebrandt, F., and Krehl, U.: Klin. Wchnschr. 4:1678 ( (Aug. 27) ) 1925. 14. Eichler, O., and Hildebrandt, F.: Arch. f. exper. Path. u. Pharmakol. 116:110, 1926. 15. Stross, William: Arch. f. exper. Path. u. Pharmakol. 114:177, 1926. 16. Schoen, R.: Arch. F. exper. Path. u. Pharmakol. 113:257, 1926. 17. Gordon, B.; Matton, M., and Levine, S. A.: J. Clin. Investigation 1:497 ( (Aug.) ) 1925. 18. We are indebted to E. Bilhuber of New York for a liberal supply of this drug that was used in this investigation. 19. Bayliss, W. M.: Intravenous Injection in Wound Shock , Brit. M. J. 2: 553, 1918. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

CARDIAZOL: SOME EXPERIMENTAL EFFECTS OF THIS DRUG ON THE CARDIORESPIRATORY MECHANISM

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Publisher
American Medical Association
Copyright
Copyright © 1928 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1928.00130190017002
Publisher site
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Abstract

Abstract Much has been written of late, especially in the continental medical journals, as to the value of cardiazol (penta-methyl-tetrazol). It has been recommended especially in cases of acute cardiovascular collapse and respiratory failure. Glowing reports are appearing of its use in varied conditions, such as pneumonia, surgical shock, intrapartum asphyxia, auricular fibrillation, angina pectoris, diabetic coma, scopolamine depression and other conditions. The bulk of these reports, however, are of poorly controlled clinical observations made on a small number of cases, usually from three to six, when other stimulants had previously been given. It is our purpose in this paper to give a short summary of the pharmacology of cardiazol and to report some experimental work concerning the points for which it is most recommended. Camphor has long been used as a cardiac stimulant, especially in acute conditions and in moribund states. Lewin,1 in 1890, and Schwalb,2 in 1912, found it References 1. Lewin, A.: Arch. f. exper. Path. u. Pharmakol. 27:226, 1890.Crossref 2. Schwalb, H.: Arch. f. exper. Path. u. Pharmakol. 70:70, 1912.Crossref 3. Joachinoglu, G.: Arch. f. exper. Path. u. Pharmakol. 80:259, 1916.Crossref 4. Heathcote, R. A.: J. Pharm. & Exper. Therap. 21:177 ( (April) ) 1923. 5. Sollmann, T.: A Manual of Pharmacology , Philadelphia, W. B. Saunders Company, 1922, p. 493. 6. Cushney, A. R.: Pharmacology and Therapy , Philadelphia, Lea & Febiger, 1924, p. 72. 7. J. A. M. A. 90:2019 ( (June 23) ) 1928 8. Marvin, H. M., and Soifer, J. D.: Value of Camphor-in-Oil as a Cardiac Stimulant , J. A. M. A. 83:94 ( (July) ) 1924. 9. Wolf and Sherman: Clin. Med. 33:8 ( (Aug.) ) 1926. 10. Schmiederberg and Meyer: Ztschr. f. Phys. Chem. 3:422, 1924. 11. Gottlieb, R., and Schuleman, W.: Deutsche med. Wchnschr. 49:1536 ( (Dec.) ) 1923. 12. Hemmerling: Deutsche med. Wchnschr. 51:1618, 1925. 13. Schmidt, K. F.: Hildebrandt, F., and Krehl, U.: Klin. Wchnschr. 4:1678 ( (Aug. 27) ) 1925. 14. Eichler, O., and Hildebrandt, F.: Arch. f. exper. Path. u. Pharmakol. 116:110, 1926. 15. Stross, William: Arch. f. exper. Path. u. Pharmakol. 114:177, 1926. 16. Schoen, R.: Arch. F. exper. Path. u. Pharmakol. 113:257, 1926. 17. Gordon, B.; Matton, M., and Levine, S. A.: J. Clin. Investigation 1:497 ( (Aug.) ) 1925. 18. We are indebted to E. Bilhuber of New York for a liberal supply of this drug that was used in this investigation. 19. Bayliss, W. M.: Intravenous Injection in Wound Shock , Brit. M. J. 2: 553, 1918.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jul 1, 1928

References