Abstract • Cardiac chamber dimensions and myocardial function were studied in 15 children with primary hypothyroidism prior to and after thyroxine therapy. Small pericardial effusions were detected in 11 of 15 subjects before therapy, which resolved in nine of 11 subjects after initiation of thyroxine replacement. There was no association between the severity of the thyroid failure and the presence of effusion, and no evidence of cardiac compromise due to effusions. No significant abnormality in cardiac chamber or myocardial dimensions, systolic time intervals, or indices of myocardial contractility was detected among the hypothyroid children as compared with a normal population. Neither myocardial dimensions nor contractility indices changed significantly on reestablishment of normal thyroxine concentrations with exogenous hormone. These data refute the existence of a myocardiopathy associated with hypothyroidism in children. (Am J Dis Child 134:556-559, 1980) References 1. Sahn DJ, DeMaria A, Kisslo J, et al: Recommendation regarding quantitation in M-mode echocardiography: Results of a survey of echocardiographic measurements . Circulation 58:1072-1083, 1978.Crossref 2. Hirschfeld S: Measurement of right and left ventricular systolic time intervals by echocardiography . Circulation 51:304-309, 1975.Crossref 3. Gutgesell HP, Paquet M, Duff DF, et al: Evaluation of left ventricular size and function by echocardiography . Circulation 56:457-462, 1977.Crossref 4. Barr AJ, Goodnight JH, Sall JP, et al: A User's Guide to SAS76 . Raleigh, NC, Sparks Press, 1976. 5. Guyda H, Letarte J, Dussault J, et al: Serum levels of T4, T3 and TSH during therapy of neonatal hypothyroidism. Pediatr Res 11:426, 1977.Crossref 6. Graettinger JS, Muenster JJ, Checchia CS, et al: A correlation of clinical hemodynamic studies in patients with hypothyroidism . J Clin Invest 37:502-510, 1958.Crossref 7. Bough WE, Crowley WF, Ridgeway EC, et al: Myocardial function in hypothyroidism . Arch Intern Med 138:1476-1480, 1978.Crossref 8. Hillis WS, Bremner WF, Lawrie TD, et al: Systolic time intervals in thyroid disease . Clin Endocrinol 4:617-624, 1975.Crossref 9. Kerber RE, Sherman B: Echocardiographic evaluation of pericardial effusion in myxedema . Circulation 52:823-827, 1975.Crossref 10. Contis G, Nadas AS, Crigler JF Jr: Cardiac manifestations of congenital hypothyroidism in infants . Pediatrics 38:452-456, 1966.
American Journal of Diseases of Children – American Medical Association
Published: Jun 1, 1980