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CARCINOMA OF THE PANCREAS

CARCINOMA OF THE PANCREAS Abstract Over a hundred years has elapsed since carcinoma of the pancreas was first described as a clinical entity. In this period a considerable number of data have been accumulated relative to the course of the disease. However, as yet one is only rarely able to recognize it in its early phase. Furthermore, little progress has been made in the therapy of the condition; thus, carcinoma of the pancreas at present is one of the more discouraging medical problems. With the renewed interest in the cancer problem as a whole, the less common tumors become important problems for reconsideration. It is for this reason that we present this paper, in which we briefly review the development of the present knowledge of the disease; report on a series of patients, dealing in particular with the clinical course and the morbid anatomy as revealed at operation and autopsy, comparing our experiences with those References 1. Mondière, J. T.: Recherches pour servir à l'histoire pathologique du pancréas , Arch. gén. de méd. 2:36 and 265, 1836. 2. Clute, H. M.: The Problem of Cancer of the Pancreas , J. A. M. A. 107:91 ( (July 11) ) 1936.Crossref 3. Leven, N. L.: Primary Carcinoma of the Pancreas , Am. J. Cancer 18:852, 1933. 4. Parmentier, E., and Chabral, E.: Les tumeurs solides du pancréas , in Roger, G. E. H.; Widal, E., and Teissier, P. J.: Nouveau traité de médecine, et de thérapéutique , Paris, J. B. Baillière et Fils, 1923, pt. 15, p. 197. 5. Da Costa, J. M.: Cancer of the Pancreas , North. Am. Med.-Chir. Rev. 2:883, 1858. 6. Bard, L., and Pic, A.: Contribution à l'étude clinique et anatomopathologique du cancer primitif du pancréas , Rev. de méd. 8:257, 1888. 7. Mirallié, C.: Cancer primitif du pancréas , Gaz. d. hôp. 66:889, 1893. 8. Chauffard, M. A.: Le cancer du corps du pancréas , Bull. Acad. de méd. Paris 60:242, 1908. 9. Courvoisier, L. G.: Casuistisch-statistische Beiträge zur Pathologie und Chirurgie der Gallenwege , Leipzig, F. C. W. Vogel, 1890, p. 58. 10. Futcher, T. B.: Cancer of the Pancreas , Tr. A. Am. Physicians 34:284, 1919. 11. Kiefer, E. D.: Carcinoma of the Pancreas , Arch. Int. Med. 40:1 ( (July) ) 1927.Crossref 12. Ewing, J.: Neoplastic Diseases , ed. 3, Philadelphia, W. B. Saunders Company, 1931, p. 745. 13. (a) Duff, G. L.: The Clinical and Pathological Features of Carcinoma of the Body and Tail of the Pancreas , Bull. Johns Hopkins Hosp. 65:69, 1939. 14. (b) Eusterman, C. B., and Wilbur, D. L.: Primary Malignant Neoplasm of the Pancreas: A Clinical Study of Eighty-Eight Verified Cases Without Jaundice , South. M. J. 26:875, 1933.Crossref 15. (c) Grauer, F. W.: Pancreatic Carcinoma , Arch. Int. Med. 63:884 ( (May) ) 1939.Crossref 16. (d) Hick, F. K., and Mortimer, H. M.: Carcinoma of the Pancreas , J. Lab. & Clin. Med. 19:1058, 1934. 17. (e) Herringham, W. P.: Primary Cancer of the Pancreas , St. Barth. Hosp. Rep. 30:5, 1894. 18. (f) Mussey, R. D.: Pancreatic Carcinoma , M. Clin. North America 3:681, 1919. 19. (g) Rives, J. D.; Romano, S. A., and Sandifer, F. R., Jr.: Carcinoma of the Pancreas , Surg., Gynec. & Obst. 65:164, 1937. 20. Ransom, H. K.: Carcinoma of the Pancreas and Extrahepatic Bile Ducts , Am. J. Surg. 40:264, 1938. 21. Lahey, F. H., and Mackinnon, D. C.: Carcinoma of the Pancreas , S. Clin. North America 18:695, 1938. 22. Rienhoff, W. F., and Lewis, D.: Surgical Affections of the Pancreas Met with in the Johns Hopkins Hospital from 1889 to 1932 , Bull. Johns Hopkins Hosp. 54:386, 1934. 23. Friedenwald, J., and Cullen, T. S.: Carcinoma of the Pancreas: Clinical Observations , Am. J. M. Sc. 176:31, 1928. 24. Ransom, H. K.: Carcinoma of the Body and Tail of the Pancreas , Arch. Surg. 30:584 ( (April) ) 1935.Crossref 25. Keefer, C. S., and Bloomfield, A. L.: The Significance of Gastric Acidity , Bull. Johns Hopkins Hosp. 39:304, 1926. 26. Engel, A., and Lysholm, E.: Contribution à l'étude de la symptomatologie du cancer pancréatique , Acta med. Scandinav. 80:34, 1933.Crossref 27. Murphy, J. B.: Cholecysto-Intestinal, Gastro-Intestinal, and Entero-Intestinal Anastomosis, and Approximation Without Sutures (Original Research) , M. Rec. 42:665, 1892. 28. Whipple, A. O.: Surgical Treatment of Carcinoma of the Ampullary Region and Head of the Pancreas , Am. J. Surg. 40:260, 1938.Crossref 29. Whipple, A. O.; Parsons, W. B., and Mullins, C. R.: Treatment of Carcinoma of the Ampulla of Vater , Ann. Surg. 102:763, 1933.Crossref 30. Desjardins, A.: Technique de la pancréatectomie , Rev. de chir. 35:945, 1907. 31. Tripodi, A. M., and Sherwin, C. F.: Experimental Transplantation of the Pancreas into the Stomach , Arch. Surg. 28:345 ( (Feb.) ) 1934.Crossref 32. Person, E. C., Jr., and Glenn. F.: Pancreaticogastrostomy: Experimental Transplantation of the Pancreas into the Stomach , Arch. Surg. 30:530 ( (Oct.) ) 1939.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

CARCINOMA OF THE PANCREAS

Archives of Surgery , Volume 42 (1) – Jan 1, 1941

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Publisher
American Medical Association
Copyright
Copyright © 1941 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1941.01210070144007
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Abstract

Abstract Over a hundred years has elapsed since carcinoma of the pancreas was first described as a clinical entity. In this period a considerable number of data have been accumulated relative to the course of the disease. However, as yet one is only rarely able to recognize it in its early phase. Furthermore, little progress has been made in the therapy of the condition; thus, carcinoma of the pancreas at present is one of the more discouraging medical problems. With the renewed interest in the cancer problem as a whole, the less common tumors become important problems for reconsideration. It is for this reason that we present this paper, in which we briefly review the development of the present knowledge of the disease; report on a series of patients, dealing in particular with the clinical course and the morbid anatomy as revealed at operation and autopsy, comparing our experiences with those References 1. Mondière, J. T.: Recherches pour servir à l'histoire pathologique du pancréas , Arch. gén. de méd. 2:36 and 265, 1836. 2. Clute, H. M.: The Problem of Cancer of the Pancreas , J. A. M. A. 107:91 ( (July 11) ) 1936.Crossref 3. Leven, N. L.: Primary Carcinoma of the Pancreas , Am. J. Cancer 18:852, 1933. 4. Parmentier, E., and Chabral, E.: Les tumeurs solides du pancréas , in Roger, G. E. H.; Widal, E., and Teissier, P. J.: Nouveau traité de médecine, et de thérapéutique , Paris, J. B. Baillière et Fils, 1923, pt. 15, p. 197. 5. Da Costa, J. M.: Cancer of the Pancreas , North. Am. Med.-Chir. Rev. 2:883, 1858. 6. Bard, L., and Pic, A.: Contribution à l'étude clinique et anatomopathologique du cancer primitif du pancréas , Rev. de méd. 8:257, 1888. 7. Mirallié, C.: Cancer primitif du pancréas , Gaz. d. hôp. 66:889, 1893. 8. Chauffard, M. A.: Le cancer du corps du pancréas , Bull. Acad. de méd. Paris 60:242, 1908. 9. Courvoisier, L. G.: Casuistisch-statistische Beiträge zur Pathologie und Chirurgie der Gallenwege , Leipzig, F. C. W. Vogel, 1890, p. 58. 10. Futcher, T. B.: Cancer of the Pancreas , Tr. A. Am. Physicians 34:284, 1919. 11. Kiefer, E. D.: Carcinoma of the Pancreas , Arch. Int. Med. 40:1 ( (July) ) 1927.Crossref 12. Ewing, J.: Neoplastic Diseases , ed. 3, Philadelphia, W. B. Saunders Company, 1931, p. 745. 13. (a) Duff, G. L.: The Clinical and Pathological Features of Carcinoma of the Body and Tail of the Pancreas , Bull. Johns Hopkins Hosp. 65:69, 1939. 14. (b) Eusterman, C. B., and Wilbur, D. L.: Primary Malignant Neoplasm of the Pancreas: A Clinical Study of Eighty-Eight Verified Cases Without Jaundice , South. M. J. 26:875, 1933.Crossref 15. (c) Grauer, F. W.: Pancreatic Carcinoma , Arch. Int. Med. 63:884 ( (May) ) 1939.Crossref 16. (d) Hick, F. K., and Mortimer, H. M.: Carcinoma of the Pancreas , J. Lab. & Clin. Med. 19:1058, 1934. 17. (e) Herringham, W. P.: Primary Cancer of the Pancreas , St. Barth. Hosp. Rep. 30:5, 1894. 18. (f) Mussey, R. D.: Pancreatic Carcinoma , M. Clin. North America 3:681, 1919. 19. (g) Rives, J. D.; Romano, S. A., and Sandifer, F. R., Jr.: Carcinoma of the Pancreas , Surg., Gynec. & Obst. 65:164, 1937. 20. Ransom, H. K.: Carcinoma of the Pancreas and Extrahepatic Bile Ducts , Am. J. Surg. 40:264, 1938. 21. Lahey, F. H., and Mackinnon, D. C.: Carcinoma of the Pancreas , S. Clin. North America 18:695, 1938. 22. Rienhoff, W. F., and Lewis, D.: Surgical Affections of the Pancreas Met with in the Johns Hopkins Hospital from 1889 to 1932 , Bull. Johns Hopkins Hosp. 54:386, 1934. 23. Friedenwald, J., and Cullen, T. S.: Carcinoma of the Pancreas: Clinical Observations , Am. J. M. Sc. 176:31, 1928. 24. Ransom, H. K.: Carcinoma of the Body and Tail of the Pancreas , Arch. Surg. 30:584 ( (April) ) 1935.Crossref 25. Keefer, C. S., and Bloomfield, A. L.: The Significance of Gastric Acidity , Bull. Johns Hopkins Hosp. 39:304, 1926. 26. Engel, A., and Lysholm, E.: Contribution à l'étude de la symptomatologie du cancer pancréatique , Acta med. Scandinav. 80:34, 1933.Crossref 27. Murphy, J. B.: Cholecysto-Intestinal, Gastro-Intestinal, and Entero-Intestinal Anastomosis, and Approximation Without Sutures (Original Research) , M. Rec. 42:665, 1892. 28. Whipple, A. O.: Surgical Treatment of Carcinoma of the Ampullary Region and Head of the Pancreas , Am. J. Surg. 40:260, 1938.Crossref 29. Whipple, A. O.; Parsons, W. B., and Mullins, C. R.: Treatment of Carcinoma of the Ampulla of Vater , Ann. Surg. 102:763, 1933.Crossref 30. Desjardins, A.: Technique de la pancréatectomie , Rev. de chir. 35:945, 1907. 31. Tripodi, A. M., and Sherwin, C. F.: Experimental Transplantation of the Pancreas into the Stomach , Arch. Surg. 28:345 ( (Feb.) ) 1934.Crossref 32. Person, E. C., Jr., and Glenn. F.: Pancreaticogastrostomy: Experimental Transplantation of the Pancreas into the Stomach , Arch. Surg. 30:530 ( (Oct.) ) 1939.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jan 1, 1941

References