Abstract The most significant prognostic factor in any case of laryngeal carcinoma appears to be the exact site of origin of the lesion. The significance of this factor seems to be due to the fact that the supporting matrix beneath the mucosal surface of the vocal cords is made up of a dense fibrous connective tissue with little or no lymph drainage while the supporting structure beneath the epithelium of the extrinsic larynx is that of a loose areolar tissue rich in lymph supply (Lore1). In most cases an epithelial new growth arising in or about the larynx is squamous cell carcinoma. It is true that there is a variation as to maturity of structure and that acanthoma more usually arises on a vocal cord. Harris and Fig. 1.—Laryngeal air passage as seen in a coronal section. Klemperer2 stated that "histologic structure is of minor importance in determining the radiosensitivity of References 1. Lore, J. M.: Practical Anatomical Considerations of the Larynx , Laryngoscope 43:693-717, 1933.Crossref 2. Harris, W., and Klemperer, P.: Pathologic Differentiation Between Radiosensitive and Nonradiosensitive Malignant Neoplasms of the Larynx , Arch. Otolaryng. 28:355-363 ( (Sept.) ) 1938.Crossref 3. Clerf, L. H.: Hoarseness and Cancer of the Larynx , West. J. Surg. 49:599-602, 1941. 4. Hammond, A. E.: Diagnosis and Treatment of Cancer of the Larynx with a Statistical Review of Fifteen Cases , Arch. Otolaryng. 35:1-29 ( (Jan.) ) 1942.Crossref 5. Lenz, M.: Radiation Therapy of Cancer of the Larynx , in Pack, G. T., and Livingston, E. M.: Treatment of Cancer and Allied Diseases , New York, Paul B. Hoeber, Inc., 1940, vol. 1, p. 560. 6. Martin, H. E.: Selection of Treatment for Cancer of the Larynx , Ann. Otol., Rhin. & Laryng. 49:728-735, 1940. 7. Lenz, M., in discussion on Symposium on the Treatment of Carcinoma of the Pharynx and Larynx , Radiology 34:161-163, 1940. 8. Stupka, W.: Ein allseitig im Kehlkopf verwendbarer Radiumträger samt Intubator , Ztschr. f. Hals-, Nasen- u. Ohrenh. 31:293-301, 1932. 9. Coutard, H.: Roentgen Therapy of Epitheliomas of the Tonsillar Region, Hypopharynx and Larynx from 1920 to 1926 , Am. J. Roentgenol. 28:313-331, 1932. 10. Howes, W. E., and Bernstein, L.: A System of Tumor Dosage, Records and Technique as Employed at the Brooklyn Cancer Institute , Am. J. Roentgenol. 50:76-88, 1943. 11. Paterson, R.: The Radical X-Ray Treatment of the Carcinomata , Brit. J. Radiol. 9:671-679, 1936.
Archives of Otolaryngology – American Medical Association
Published: Aug 1, 1944