Abstract This paper reports a patient with an unusual form of diffuse carcinoma of the meibomian glands and the glands of Zeis. Although carcinoma of the meibomian glands classically is characterized by a discrete lesion often mistaken for a chalazion,1 this patient showed only a generalized thickening and inflammation in the lateral portions of the upper and lower lids. The diagnosis was confirmed by biopsy which further revealed pagetoid changes in the overlying epithelium. Report of Case This 72-year-old white male was seen in consultation on Sept 4, 1963. He had noticed pain and irritation on the lateral aspects of the eyelids of his left eye for one year. Treatment with antibiotic and steroid ointments had resulted in no improvement. Examination revealed a diffuse, apparently inflammatory, eczematoid thickening of the temporal 1.5 cm of the left upper and lower lids adjacent to the outer canthus of the left eye (Fig References 1. Duke-Elder, S.: Textbook of Ophthalmology: Ocular Adnexa , St. Louis: C. V. Mosby Co., 1952, vol 5. 2. Barron, C. N.: Comparative Pathology of Neoplasms of Eyelids and Conjunctiva With Special References to Those of Epithelial Origin , Acta Dermatovener (suppl 51) 42:1-100, 1962. 3. Das, S. P.: Adenocarcinoma of Meibomian Glands , J All India Ophthalmology Soc 10:36-38, 1962. 4. Fisher, D. F., in Society Proceedings, Memphis Society Ophthalmology and Otolaryngology , abstracted, Amer J Ophthal 34:633-634, 1951. 5. Hagedoorn, A.: Adenocarcinoma of Meibomian Gland , Arch Ophthal 12: 850-867, 1934.Crossref 6. Hagedoorn, A.: Adenocarcinoma of Meibomian Gland: Report of Additional Cases , Arch Ophthal 18:50-56, 1937.Crossref 7. Hartz, P. H.: Carcinoma of Meibomian Gland , Amer J Clin Path 25:636-641, 1955. 8. Hughes, C. A.: Multiple Chalazia Showing Malignancy , Trans Ophthal Soc UK 52:557-558, 1932. 9. Kennedy, R. J., and King, R. W.: Carcinoma of Meibomian Gland: Case Report , Amer J Ophthal 37:259-260, 1954. 10. Knapp, A., in discussion on O'Brian, C. S. and Braley, A. E.: Common Tumors of Eyelids , JAMA 107:937-938, 1936. 11. Lazarescu, D.; Lazarescu, E.; and Ionescu, E.: Case of Epithelioma of Meibomian Gland , Brit J Ophthal 14:588-594, 1930.Crossref 12. Lebensohn, J. E.: Primary Carcinoma of Meibomian Gland , Amer J Ophthal 18:552-554, 1935. 13. Magnus, J. A.: Adenocarcinoma of Meibomian Gland With Secondaries in Liver , Trans Ophthal Soc UK 67:432-435, 1947. 14. Mangubat, L. L., and Garcia, F. V.: Carcinoma of Meibomian Glands , Philipp J Surg 16:321-325, 1961. 15. Reese, A. B.: Tumors of Eye , ed 2, New York: Harper and Row, 1963. 16. Rice, M. L., and Lindeke, H. I.: Adenocarcinoma of Meibomian Gland , Amer J Ophthal 33:1434-1437, 1950. 17. Scott, K., and Griffith, J.: Alveolar Carcinoma of Eyelid , Trans Ophthal Soc UK 20:44-47, 1900. 18. Snell, S., and Cuff, A.: Alveolar Carcinoma of Eyelid , Trans Ophthal Soc UK 16:39-42, 1896. 19. Straatsma, B. R.: Meibomian Gland Tumors , Arch Ophthal 56:71-93, 1956.Crossref 20. Sweebe, E. C., and Cogan, D. G.: Adenocarcinoma of Meibomian Gland , Arch Ophthal 61:282-290, 1959.Crossref 21. Warren, S. and Warvi, W. H.: Tumors of Sebaceous Glands , Amer J Path 19:441-460, 1943. 22. Welch, R. B., and Duke, J. R.: Lesions of Lids: A Statistical Note , Amer J Ophthal 45: 415-416, 1958. 23. Hogan, M. J., and Zimmerman, L. E.: Ophthalmic Pathology , ed 2, Philadelphia: W. B. Saunders Co., 1962. 24. Whorten, C. M., and Patterson, J. B.: Carcinoma of Moll's Glands With Extramammary Paget's Disease of Eyelid , Cancer 8:1000-1015, 1955. 25. Allen, A. C.: Skin , St. Louis: The C. V. Mosby Co., 1954.
Archives of Ophthalmology – American Medical Association
Published: Dec 1, 1964
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