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Carbamazepine in Febrile Seizures

Carbamazepine in Febrile Seizures Abstract Sir.—We read the article by Antony and Hawke1 about the place of phenobarbital sodium or carbamazepine in the prophylaxis of febrile seizures with interest. In their double-blind trial they show that phenobarbital is the best anticonvulsant to prevent febrile seizures, and that carbamazepine is not effective. We do not share this viewpoint, based on our own experience. In a prospective study during an 18-month trial,2 we showed that carbamazepine is very effective in atypical febrile seizures which begin before 1 year of age, have a focal onset, persist more than 15 minutes, are followed by a transient hemiplegia, or are accompanied by focal spikes on EEG recordings. In another article,3 we showed that carbamazepine was very effective in the prophylaxis of febrile seizures in phenobarbital failures. In each instance, carbamazepine was well tolerated. We think that carbamazepine can be useful in the prophylaxis of unusual febrile References 1. Antony JH, Hawke SHB: Phenobarbital compared with carbamazepine in prevention of recurrent febrile convulsions . AJDC 1983;137: 892-895. 2. Giroud M, Langevin P, Dumas R: Results of long-term utilization of carbamazepine in childhood , in DeNegri M (ed): Proceedings of the Second Congress of the Socièté de Neurologie Infantile. Genoa, Italy, Gaslini, 1981, pp 196-197. 3. Giroud M, Dumas R, Langevin P: Carbamazepine in prophylaxis of febrile seizures in phenobarbital failures . Neurology 1983;33:1532.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Carbamazepine in Febrile Seizures

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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1985.02140030011005
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—We read the article by Antony and Hawke1 about the place of phenobarbital sodium or carbamazepine in the prophylaxis of febrile seizures with interest. In their double-blind trial they show that phenobarbital is the best anticonvulsant to prevent febrile seizures, and that carbamazepine is not effective. We do not share this viewpoint, based on our own experience. In a prospective study during an 18-month trial,2 we showed that carbamazepine is very effective in atypical febrile seizures which begin before 1 year of age, have a focal onset, persist more than 15 minutes, are followed by a transient hemiplegia, or are accompanied by focal spikes on EEG recordings. In another article,3 we showed that carbamazepine was very effective in the prophylaxis of febrile seizures in phenobarbital failures. In each instance, carbamazepine was well tolerated. We think that carbamazepine can be useful in the prophylaxis of unusual febrile References 1. Antony JH, Hawke SHB: Phenobarbital compared with carbamazepine in prevention of recurrent febrile convulsions . AJDC 1983;137: 892-895. 2. Giroud M, Langevin P, Dumas R: Results of long-term utilization of carbamazepine in childhood , in DeNegri M (ed): Proceedings of the Second Congress of the Socièté de Neurologie Infantile. Genoa, Italy, Gaslini, 1981, pp 196-197. 3. Giroud M, Dumas R, Langevin P: Carbamazepine in prophylaxis of febrile seizures in phenobarbital failures . Neurology 1983;33:1532.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jan 1, 1985

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