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CAPACITY OF REINNERVATED MUSCLES TO FUNCTION EFFICIENTLY AFTER PROLONGED DENERVATION

CAPACITY OF REINNERVATED MUSCLES TO FUNCTION EFFICIENTLY AFTER PROLONGED DENERVATION Abstract THE CHANGES which develop in a muscle which has been deprived of its nerve supply are now well known, though several details relating to the processes involved remain obscure. It is generally recognized, however, that prolonged denervation ultimately leads to a condition which is incompatible with the restoration of useful function, even though the muscle has been satisfactorily reinnervated. Despite its considerable practical importance, there is still no reliable information as to the point at which the changes become irreversible. The object of this paper is to provide data relating to the reinnervation of human muscles after long periods of denervation and their capacity to function effciently offer such reinnervation. An attempt has also been made to ascertain the extent to which the residual defect after delayed nerve repair is attributable to changes in the nerve itself and how much it is due to progressive changes in the denervated muscle. References 1. Gutmann, E., and Young, J. Z.: The Re-Innervation of Muscle After Various Periods of Atrophy , J. Anat. 78:15, 1944. 2. Gutmann, E.: Effect of Delay of Innervation on Recovery of Muscle After Nerve Lesions , J. Neurophysiol. 11:279, 1948. 3. Bowden, R. E. M., and Gutmann, E.: Denervation and Re-Innervation of Human Voluntary Muscle , Brain 67:273, 1944.Crossref 4. Sunderland, S., and Ray, L. J.: Denervation Changes in Mammalian Striated Muscle , J. Neurol., Neurosurg. & Psychiat. 13:159, 1950. 5. Sunderland, S.: Observations on the Course of Recovery and Late End Results in a Series of Cases of Peripheral Nerve Suture , Australian & New Zealand J. Surg. 18:264, 1949. 6. Sunderland, S.: Rate of Regeneration in Human Peripheral Nerves: Analysis of Interval Between Injury and Onset of Recovery , Arch. Neurol. & Psychiat. 58:251 ( (Sept.) ) 1947 7. correction, 59:416 (March) 1948. 8. Sunderland, S.: Voluntary Movements and the Deceptive Action of Muscle in Peripheral Nerve Lesions , Australian & New Zealand J. Surg. 13:160, 1944. 9. Sunderland, S.: The Significance of Hypothenar Elevation in Movements of Opposition of the Thumb , Australian & New Zealand J. Surg. 13:155, 1944. 10. Aitken, J. T.; Sharman, M., and Young, J. Z.: Maturation of Regenerating Nerve Fibres with Various Peripheral Connexions , J. Anat. 81:1, 1947. 11. Sunderland.5 12. Sunderland, S., and Bradley, K. C.: Endoneurial Tube Shrinkage in the Distal Segment of a Severed Nerve , J. Comp. Neurol. , to be published. 13. Campbell, B.: The Effects of Retrograde Degeneration upon Reflex Activity of Ventral Horn Neurons , Anat. Rec. 88:25, 1944. 14. Sunderland, S., and Bedbrook, G. M.: The Cross-Sectional Area of Peripheral Nerve Trunks Occupied by the Fibres Representing Individual Muscular and Cutaneous Branches , Brain 72:613, 1949. 15. Sunderland, S.: The Intraneural Topography of the Radial, Median, and Ulnar Nerves , Brain 68:243, 1945. 16. Sunderland, S., and Ray, L. J.: The Intraneural Topography of the Sciatic Nerve and Its Popliteal Divisions in Man , Brain 71:242, 1948. 17. Sunderland, S., and Bradley, K. C.: Denervation Atrophy of the Distal Stump of a Severed Nerve , J. Comp. Neurol. , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

CAPACITY OF REINNERVATED MUSCLES TO FUNCTION EFFICIENTLY AFTER PROLONGED DENERVATION

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Publisher
American Medical Association
Copyright
Copyright © 1950 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1950.02310300002001
Publisher site
See Article on Publisher Site

Abstract

Abstract THE CHANGES which develop in a muscle which has been deprived of its nerve supply are now well known, though several details relating to the processes involved remain obscure. It is generally recognized, however, that prolonged denervation ultimately leads to a condition which is incompatible with the restoration of useful function, even though the muscle has been satisfactorily reinnervated. Despite its considerable practical importance, there is still no reliable information as to the point at which the changes become irreversible. The object of this paper is to provide data relating to the reinnervation of human muscles after long periods of denervation and their capacity to function effciently offer such reinnervation. An attempt has also been made to ascertain the extent to which the residual defect after delayed nerve repair is attributable to changes in the nerve itself and how much it is due to progressive changes in the denervated muscle. References 1. Gutmann, E., and Young, J. Z.: The Re-Innervation of Muscle After Various Periods of Atrophy , J. Anat. 78:15, 1944. 2. Gutmann, E.: Effect of Delay of Innervation on Recovery of Muscle After Nerve Lesions , J. Neurophysiol. 11:279, 1948. 3. Bowden, R. E. M., and Gutmann, E.: Denervation and Re-Innervation of Human Voluntary Muscle , Brain 67:273, 1944.Crossref 4. Sunderland, S., and Ray, L. J.: Denervation Changes in Mammalian Striated Muscle , J. Neurol., Neurosurg. & Psychiat. 13:159, 1950. 5. Sunderland, S.: Observations on the Course of Recovery and Late End Results in a Series of Cases of Peripheral Nerve Suture , Australian & New Zealand J. Surg. 18:264, 1949. 6. Sunderland, S.: Rate of Regeneration in Human Peripheral Nerves: Analysis of Interval Between Injury and Onset of Recovery , Arch. Neurol. & Psychiat. 58:251 ( (Sept.) ) 1947 7. correction, 59:416 (March) 1948. 8. Sunderland, S.: Voluntary Movements and the Deceptive Action of Muscle in Peripheral Nerve Lesions , Australian & New Zealand J. Surg. 13:160, 1944. 9. Sunderland, S.: The Significance of Hypothenar Elevation in Movements of Opposition of the Thumb , Australian & New Zealand J. Surg. 13:155, 1944. 10. Aitken, J. T.; Sharman, M., and Young, J. Z.: Maturation of Regenerating Nerve Fibres with Various Peripheral Connexions , J. Anat. 81:1, 1947. 11. Sunderland.5 12. Sunderland, S., and Bradley, K. C.: Endoneurial Tube Shrinkage in the Distal Segment of a Severed Nerve , J. Comp. Neurol. , to be published. 13. Campbell, B.: The Effects of Retrograde Degeneration upon Reflex Activity of Ventral Horn Neurons , Anat. Rec. 88:25, 1944. 14. Sunderland, S., and Bedbrook, G. M.: The Cross-Sectional Area of Peripheral Nerve Trunks Occupied by the Fibres Representing Individual Muscular and Cutaneous Branches , Brain 72:613, 1949. 15. Sunderland, S.: The Intraneural Topography of the Radial, Median, and Ulnar Nerves , Brain 68:243, 1945. 16. Sunderland, S., and Ray, L. J.: The Intraneural Topography of the Sciatic Nerve and Its Popliteal Divisions in Man , Brain 71:242, 1948. 17. Sunderland, S., and Bradley, K. C.: Denervation Atrophy of the Distal Stump of a Severed Nerve , J. Comp. Neurol. , to be published.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Dec 1, 1950

References