Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Canaries in a Coal Mine

Canaries in a Coal Mine COMMENTARY Cognitive Markers of Preclinical Alzheimer Disease N THE EARLY 20th century, tion of changes in cognitive perfor- comparable rates of longitudinal coal miners brought caged mance that precede AD during the pe- changes on a broad indicator of cog- canaries into the mines with riod when persons are still considered nitive functioning as well as on spe- them as a warning device for to be diagnostically healthy. The work cific measures of episodic memory, I noxious gases. When the ca- of Chen and colleagues adds to the even though clear group differences naries would begin to behave unusu- growing body of literature demon- were present at time 1. However, be- ally, the coal miners would know to strating that cross-sectional deficits tween time 2 and time 3, the 3 years leave the mines for fear of being over- in cognitive performance can ap- preceding diagnosis, the incident AD 7 5 come by deadly levels of carbon mon- pear years to decades before the di- group experienced precipitous de- oxide. Now, in the 21st century, sci- agnosis of AD. Furthermore, their re- clines on almost all measures of func- entists are looking for their own sults extend previous work http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Canaries in a Coal Mine

Download PDF
2 pages

Loading next page...
 
/lp/american-medical-association/canaries-in-a-coal-mine-0SS2y73Sst
Publisher
American Medical Association
Copyright
Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archpsyc.58.9.859
Publisher site
See Article on Publisher Site

Abstract

COMMENTARY Cognitive Markers of Preclinical Alzheimer Disease N THE EARLY 20th century, tion of changes in cognitive perfor- comparable rates of longitudinal coal miners brought caged mance that precede AD during the pe- changes on a broad indicator of cog- canaries into the mines with riod when persons are still considered nitive functioning as well as on spe- them as a warning device for to be diagnostically healthy. The work cific measures of episodic memory, I noxious gases. When the ca- of Chen and colleagues adds to the even though clear group differences naries would begin to behave unusu- growing body of literature demon- were present at time 1. However, be- ally, the coal miners would know to strating that cross-sectional deficits tween time 2 and time 3, the 3 years leave the mines for fear of being over- in cognitive performance can ap- preceding diagnosis, the incident AD 7 5 come by deadly levels of carbon mon- pear years to decades before the di- group experienced precipitous de- oxide. Now, in the 21st century, sci- agnosis of AD. Furthermore, their re- clines on almost all measures of func- entists are looking for their own sults extend previous work

Journal

JAMA Psychiatry – American Medical Association

Published: Sep 1, 2001

References

  • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
    Schenk, D; Barbour, R; Dunn, W; Gordon, G; Grajeda, H; Guido, T; Hu, K; Huang, J; Johnson-Wood, K; Khan, K; Kholodenko, D; Lee, M; Liao, Z; Lieberburg, I; Motter, R; Mutter, L; Soriano, F; Shopp, G; Vasquez, N; Vandevert, C; Walker, S; Wogulis, M; Yednock, T; Games, D; Seubert, P
  • Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.
    Brookmeyer, R; Gray, S; Kawas, C
  • Patterns of cognitive decline in pre-symptomatic Alzheimer disease: a prospective community study.
    Chen, P; Ratcliff, G; Belle, SH; Cauley, JA; DeKosky, ST; Ganguli, M
  • Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented.
    Chen, P; Ratcliff, G; Belle, SH; Cauley, JA; DeKosky, ST; Ganguli, M
  • The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort.
    Elias, MF; Beiser, A; Wolf, PA; Au, R; White, RF; D'Agostino, RB
  • Cognitive predictors of incident Alzheimer's disease: a prospective longitudinal study.
    Small, BJ; Herlitz, A; Fratiglioni, L; Almkvist, O; Bäckman, L
  • Mini-Mental State Examination item scores as predictors of Alzheimer's disease: incidence data from the Kungsholmen project, Stockholm.
    Small, BJ; Viitanen, M; Bäckman, L
  • Stability of the preclinical episodic memory deficit in Alzheimer's disease.
    Bäckman, L; Small, BJ; Fratiglioni, L
  • Absence of cognitive impairment or decline in preclinical Alzheimer's disease.
    Goldman, WP; Price, JL; Storandt, M; Grant, EA; McKeel Jr, DW; Rubin, EH; Morris, JC
  • The course of cognitive impairment in preclinical Alzheimer disease: 3- and 6-year follow-up of a population-based sample.
    Small, BJ; Fratiglioni, L; Viitanen, M; Winblad, B; Bäckman, L
  • Linguistic ability in early life and cognitive function and Alzheimer's disease in late life: findings from the Nun Study.
    Snowdon, DA; Kemper, SJ; Mortimer, JA; Greiner, LH; Wekstein, DR; Markesbery, WR
  • Childhood mental ability and dementia.
    Whalley, LJ; Starr, JM; Athawes, R; Hunter, D; Pattie, A; Deary, IJ
  • Staging of Alzheimer's disease-related neurofibrillary tangles.
    Braak, H; Braak, E
  • "Preclinical" AD revisited: neuropathology of cognitively normal older adults.
    Schmitt, FA; Davis, DG; Wekstein, DR; Smith, CD; Ashford, JW; Markesbery, WR
  • Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease.
    De Leon, MJ; George, AE; Golomb, J; Tarshish, C; Convit, A; Kluger, A; De Santi, S; McRae, T; Ferris, SH; Reisberg, B; Ince, C; Rusinek, H; Bobinski, M; Quinn, B; Miller, DC; Wisniewski, HM
  • Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment.
    Jack Jr, CR; Petersen, RC; Xu, YC; O-Brien, PC; Smith, GE; Ivnik, RJ; Boeve, BF; Waring, SC; Tangalos, EG; Kokmen, E
  • Mild cognitive impairment: clinical characterization and outcome.
    Petersen, RC; Smith, GE; Waring, SC; Ivnik, RJ; Tangalos, EG; Kokmen, E
  • Mild cognitive impairment represents early-stage Alzheimer disease.
    Morris, JC; Storandt, M; Miller, JP; McKeel, DW; Price, JL; Rubin, EH; Berg, L