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Canaries in a Coal Mine

Canaries in a Coal Mine COMMENTARY Cognitive Markers of Preclinical Alzheimer Disease N THE EARLY 20th century, tion of changes in cognitive perfor- comparable rates of longitudinal coal miners brought caged mance that precede AD during the pe- changes on a broad indicator of cog- canaries into the mines with riod when persons are still considered nitive functioning as well as on spe- them as a warning device for to be diagnostically healthy. The work cific measures of episodic memory, I noxious gases. When the ca- of Chen and colleagues adds to the even though clear group differences naries would begin to behave unusu- growing body of literature demon- were present at time 1. However, be- ally, the coal miners would know to strating that cross-sectional deficits tween time 2 and time 3, the 3 years leave the mines for fear of being over- in cognitive performance can ap- preceding diagnosis, the incident AD 7 5 come by deadly levels of carbon mon- pear years to decades before the di- group experienced precipitous de- oxide. Now, in the 21st century, sci- agnosis of AD. Furthermore, their re- clines on almost all measures of func- entists are looking for their own sults extend previous work http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archpsyc.58.9.859
Publisher site
See Article on Publisher Site

Abstract

COMMENTARY Cognitive Markers of Preclinical Alzheimer Disease N THE EARLY 20th century, tion of changes in cognitive perfor- comparable rates of longitudinal coal miners brought caged mance that precede AD during the pe- changes on a broad indicator of cog- canaries into the mines with riod when persons are still considered nitive functioning as well as on spe- them as a warning device for to be diagnostically healthy. The work cific measures of episodic memory, I noxious gases. When the ca- of Chen and colleagues adds to the even though clear group differences naries would begin to behave unusu- growing body of literature demon- were present at time 1. However, be- ally, the coal miners would know to strating that cross-sectional deficits tween time 2 and time 3, the 3 years leave the mines for fear of being over- in cognitive performance can ap- preceding diagnosis, the incident AD 7 5 come by deadly levels of carbon mon- pear years to decades before the di- group experienced precipitous de- oxide. Now, in the 21st century, sci- agnosis of AD. Furthermore, their re- clines on almost all measures of func- entists are looking for their own sults extend previous work

Journal

JAMA PsychiatryAmerican Medical Association

Published: Sep 1, 2001

References