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Can Chronic Sinusitis Cause Cancer?

Can Chronic Sinusitis Cause Cancer? Research Original Investigation Chronic Sinusitis and Risk of Head and Neck Cancer in US Elderly Invited Commentary Elisabeth H. Ference, MD, MPH; Jeffrey D. Suh, MD Can the inflammation associated with chronic rhinosinusitis CI, 1.26-1.39) and Hodgkin lymphoma (aHR, 1.59; 95% CI, 1.26- (CRS) contribute to the development of head and neck 2.00) were also both associated with CRS. cancer, especially nasal cavity or paranasal sinus cancer? Or Distinguishing between short-term and long-term asso- is any association between CRS due to reverse causation be- ciations of sinusitis and cancer is critical because short-term cause nasal and sinus cancer can present initially with sinus- associations may be due to symptoms caused by a yet undis- itis symptoms? covered malignant neoplasm, whereas longer-term associa- Inflammatory insults in other areas of the body have a well- tions may better reflect the chronic effects of inflammation or established etiologic link with malignancy. For example, gas- immunosuppression on oncogenesis. Whereas nasal cavity and troesophageal reflux disease may lead to Barrett metaplasia and paranasal sinus cancers were found to have a weak but sig- esophageal cancer, and ulcerative colitis has been associated nificant longer-term association with CRS in the study by with colon cancer. The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

Can Chronic Sinusitis Cause Cancer?

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Publisher
American Medical Association
Copyright
Copyright 2016 American Medical Association. All Rights Reserved.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/jamaoto.2016.2649
pmid
27606608
Publisher site
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Abstract

Research Original Investigation Chronic Sinusitis and Risk of Head and Neck Cancer in US Elderly Invited Commentary Elisabeth H. Ference, MD, MPH; Jeffrey D. Suh, MD Can the inflammation associated with chronic rhinosinusitis CI, 1.26-1.39) and Hodgkin lymphoma (aHR, 1.59; 95% CI, 1.26- (CRS) contribute to the development of head and neck 2.00) were also both associated with CRS. cancer, especially nasal cavity or paranasal sinus cancer? Or Distinguishing between short-term and long-term asso- is any association between CRS due to reverse causation be- ciations of sinusitis and cancer is critical because short-term cause nasal and sinus cancer can present initially with sinus- associations may be due to symptoms caused by a yet undis- itis symptoms? covered malignant neoplasm, whereas longer-term associa- Inflammatory insults in other areas of the body have a well- tions may better reflect the chronic effects of inflammation or established etiologic link with malignancy. For example, gas- immunosuppression on oncogenesis. Whereas nasal cavity and troesophageal reflux disease may lead to Barrett metaplasia and paranasal sinus cancers were found to have a weak but sig- esophageal cancer, and ulcerative colitis has been associated nificant longer-term association with CRS in the study by with colon cancer. The

Journal

JAMA Otolaryngology - Head & Neck Surgery – American Medical Association

Published: Jan 8, 2017

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