Abstract The administration of salts of potassium has been recently advocated for the treatment of urticaria and certain other allergic diseases.1 It has been known for a number of years that this element may have epinephrine-like effects under certain circumstances.2 The effective action of epinephrine in allergic states, therefore, is sufficient reason to prompt the trial of a potassium salt to combat them. It has been claimed3 that the blood potassium level rises during allergic attacks and recedes with improvement. The increase in the concentration of potassium of the blood has been thought to be contributed by the supply in the tissue cells. Some investigators4 have felt that if this current of potassium away from the cells could be reversed and the element driven back into them the accompanying allergic phenomena would be ameliorated. Accordingly, they have put this reasoning to trial, with conflicting results.4 For References 1. Bloom, B., and Grauman, S. J.: Southwestern Med. 23:205, 1939. 2. Camp, W. J. R., and Higgins, J. A.: J. Pharmacol. & Exper. Therap. 57:376, 1936. 3. Rusk, H. A.; Weichselbaum, T. E., and Somogyi, M.: Changes in Serum Potassium in Certain Allergic States , J. A. M. A. 112:2395 ( (June 10) ) 1939. 4. Engelsher, D. L.: Potassium Chloride in Allergy, Correspondence , J. A. M. A. 113:961 ( (Sept. 2) ) 1939. 5. Breh, F., and Gaebler, O. H.: J. Biol. Chem. 87:81, 1930. 6. Kuttner, T. T., and Cohen, H. R.: J. Biol. Chem. 75:517, 1927. 7. Yoshimatsu, S.: Tohoku J. Exper. Med. 8:496, 1927. 8. Borelli, F.: Dermosifilografo 7:353, 1932. 9. Stern, F.: Klin. Wchnschr. 10:1944, 1931. 10. Nathan, E., and Stern, F.: Dermat. Ztschr. 54:232, 1928. 11. (a) Dahn, W.: Dermat. Wchnschr. 82:425, 1926. 12. (b) Bohnstedt, R. M.: Klin. Wchnschr. 10:1666, 1931. 13. (c) Carandante, G., cited by Pillsbury, D. M.: Ann. Rev. Physiol. 2:151, 1940 14. Bull. d. Soc. ital. di biol. sper. 13:1097, 1938. 15. Stern, F.: Klin. Wchnschr. 11:1453, 1932. 16. Sulzberger, M., and Mayer, R. L.: Sensitizations: Regional, Seasonal, Dietary and Other Influences Accounting for Variations and Fluctuations , Arch. Dermat. & Syph. 24:537 ( (Oct.) ) 1931. 17. Klauder, J. V., and Brown, H.: (a) Experimental Studies in Eczema: II. Correlation of the Chemistry with Irritability of Skin of Animals Under Normal and Under Experimentally Induced Conditions , Arch. Dermat. & Syph. 15:1 ( (Jan.) ) 1927 18. (b) IV. A Correlation of Potassium Calcium Ratio in the Serum and in the Skin of Rabbits with Irritability of the Skin , Klauder Arch. Dermat. & Syph. 20:326 ( (Sept.) ) 1929.
Archives of Dermatology and Syphilology – American Medical Association
Published: Dec 1, 1942