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A. Sugarman, T. Kahn (1988)
Parathyroid hormone impairs extrarenal potassium tolerance in the rat.The American journal of physiology, 254 3 Pt 2
Flicker Mr, Q. Ma, Caldwell Eg (1987)
Diltiazem and hyperkalemia.JAMA, 258 14
A. Sugarman, T. Kahn (1986)
Calcium channel blockers enhance extrarenal potassium disposal in the rat.The American journal of physiology, 250 4 Pt 2
R. Hoyt (1986)
Hyperkalemia due to salt substitutes.JAMA, 256 13
J. Putney (1978)
Stimulus-permeability coupling: role of calcium in the receptor regulation of membrane permeability.Pharmacological reviews, 30 2
G. Gárdos (1958)
The function of calcium in the potassium permeability of human erythrocytes.Biochimica et biophysica acta, 30 3
R. Meech (1978)
Calcium-dependent potassium activation in nervous tissues.Annual review of biophysics and bioengineering, 7
To the Editor. —Recent letters to JAMA have discussed the issue of hyperkalemia in association with the use of calcium channel antagonists.1,2 The link between calcium and potassium transport at the cellular level has been well recognized. Membrane permeability to potassium in many cell types has been shown to be related to the concentration of intracellular calcium.3 Studies have revealed that maneuvers designed to increase effective intracellular calcium concentration enhance net potassium efflux from cells,4 whereas those directed at reducing effective intracellular calcium concentration impair net potassium efflux from cells.5 Our studies have shown that verapamil and nifedipine enhance the extrarenal disposal of an acute intravenous potassium load administered to acutely nephrectomized rats.6 This enhanced extrarenal potassium tolerance could not be accounted for by the intervention of insulin, aldosterone, or β2-catecholamines. We postulated that the impaired calcium entry into cells mediated by the
JAMA – American Medical Association
Published: Jan 22, 1988
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