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Calcium Antagonists and Potassium Balance

Calcium Antagonists and Potassium Balance To the Editor. —Recent letters to JAMA have discussed the issue of hyperkalemia in association with the use of calcium channel antagonists.1,2 The link between calcium and potassium transport at the cellular level has been well recognized. Membrane permeability to potassium in many cell types has been shown to be related to the concentration of intracellular calcium.3 Studies have revealed that maneuvers designed to increase effective intracellular calcium concentration enhance net potassium efflux from cells,4 whereas those directed at reducing effective intracellular calcium concentration impair net potassium efflux from cells.5 Our studies have shown that verapamil and nifedipine enhance the extrarenal disposal of an acute intravenous potassium load administered to acutely nephrectomized rats.6 This enhanced extrarenal potassium tolerance could not be accounted for by the intervention of insulin, aldosterone, or β2-catecholamines. We postulated that the impaired calcium entry into cells mediated by the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Calcium Antagonists and Potassium Balance

JAMA , Volume 259 (4) – Jan 22, 1988

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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1988.03720040017017
Publisher site
See Article on Publisher Site

Abstract

To the Editor. —Recent letters to JAMA have discussed the issue of hyperkalemia in association with the use of calcium channel antagonists.1,2 The link between calcium and potassium transport at the cellular level has been well recognized. Membrane permeability to potassium in many cell types has been shown to be related to the concentration of intracellular calcium.3 Studies have revealed that maneuvers designed to increase effective intracellular calcium concentration enhance net potassium efflux from cells,4 whereas those directed at reducing effective intracellular calcium concentration impair net potassium efflux from cells.5 Our studies have shown that verapamil and nifedipine enhance the extrarenal disposal of an acute intravenous potassium load administered to acutely nephrectomized rats.6 This enhanced extrarenal potassium tolerance could not be accounted for by the intervention of insulin, aldosterone, or β2-catecholamines. We postulated that the impaired calcium entry into cells mediated by the

Journal

JAMAAmerican Medical Association

Published: Jan 22, 1988

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