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CALCIFICATION IN THE SUBCUTANEOUS TISSUES: REPORT OF A CASE ASSOCIATED WITH CHRONIC ATROPHIC ARTHRITIS

CALCIFICATION IN THE SUBCUTANEOUS TISSUES: REPORT OF A CASE ASSOCIATED WITH CHRONIC ATROPHIC... Abstract A brief résumé of the various theories advanced to explain the formation of the deposits of calcium or calcification follows. Pauli and Samec1 showed that in a colloidal albuminous solution, calcium carbonate and calcium phosphate are many times more soluble than in water. These salts could therefore be carried in the blood in nearly the same form as they are found in the deposits. Holt, La Mer and Chown2 demonstrated that blood serum is normally saturated up to 200 per cent with neutral calcium phosphate, and that this salt will remain for days without precipitating. They thought, however, that most of the calcium is carried in the form of the much more readily soluble acid carbonate and acid phosphates which may be changed into the neutral salts by the loss of carbon dioxide. Barille3 held that calcium is contained in the blood as a double salt, calcium References 1. Pauli, W., and Samec, M.: Ueber Löslichkeitsbeeinflussung von Electrolyten durch Eweisskorper , Biochem. Ztschr. 17:235, 1909. 2. Holt, L. E.; La Mer, V. K., and Chown, H. B.: Studies in Calcification: I, II and III , J. Biol. Chem. 64:509, 1925. 3. Barille, A.: De l'action de l'acide carbonique sous pression sur les phosphates metalliques; combinasion (carbonophosphates) ou dissolution, applications diversés , J. de pharm. et chim. (series 6) 19:14, 71, 196, 245 and 295, 1904 4. (series 7) 1:342, 1910. 5. Wells, H. G.: Pathologic Calcification , J. M. Research 9:491, 1906 6. Chemical Pathology , Philadelphia, W. B. Saunders Company, 1918. 7. Klotz, O.: Studies upon Calcareous Degeneration , J. Exper. Med. 7:633, 1905Crossref 8. On the Presence of Soaps in the Organism in Certain Pathological Conditions , Am. J. Physiol. 13:21, 1905. 9. Watt, J. C.: The Deposition of Calcium Phosphates and Calcium Carbonate in Bone and in Areas of Calcification , Arch. Surg. 10:983 ( (May) ) 1925Crossref 10. The Deposition of Calcium Salts in Areas of Calcification , Watt Arch. Surg. 15:89 ( (July) ) 1927.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

CALCIFICATION IN THE SUBCUTANEOUS TISSUES: REPORT OF A CASE ASSOCIATED WITH CHRONIC ATROPHIC ARTHRITIS

Archives of Surgery , Volume 23 (3) – Sep 1, 1931

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Publisher
American Medical Association
Copyright
Copyright © 1931 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1931.01160090158006
Publisher site
See Article on Publisher Site

Abstract

Abstract A brief résumé of the various theories advanced to explain the formation of the deposits of calcium or calcification follows. Pauli and Samec1 showed that in a colloidal albuminous solution, calcium carbonate and calcium phosphate are many times more soluble than in water. These salts could therefore be carried in the blood in nearly the same form as they are found in the deposits. Holt, La Mer and Chown2 demonstrated that blood serum is normally saturated up to 200 per cent with neutral calcium phosphate, and that this salt will remain for days without precipitating. They thought, however, that most of the calcium is carried in the form of the much more readily soluble acid carbonate and acid phosphates which may be changed into the neutral salts by the loss of carbon dioxide. Barille3 held that calcium is contained in the blood as a double salt, calcium References 1. Pauli, W., and Samec, M.: Ueber Löslichkeitsbeeinflussung von Electrolyten durch Eweisskorper , Biochem. Ztschr. 17:235, 1909. 2. Holt, L. E.; La Mer, V. K., and Chown, H. B.: Studies in Calcification: I, II and III , J. Biol. Chem. 64:509, 1925. 3. Barille, A.: De l'action de l'acide carbonique sous pression sur les phosphates metalliques; combinasion (carbonophosphates) ou dissolution, applications diversés , J. de pharm. et chim. (series 6) 19:14, 71, 196, 245 and 295, 1904 4. (series 7) 1:342, 1910. 5. Wells, H. G.: Pathologic Calcification , J. M. Research 9:491, 1906 6. Chemical Pathology , Philadelphia, W. B. Saunders Company, 1918. 7. Klotz, O.: Studies upon Calcareous Degeneration , J. Exper. Med. 7:633, 1905Crossref 8. On the Presence of Soaps in the Organism in Certain Pathological Conditions , Am. J. Physiol. 13:21, 1905. 9. Watt, J. C.: The Deposition of Calcium Phosphates and Calcium Carbonate in Bone and in Areas of Calcification , Arch. Surg. 10:983 ( (May) ) 1925Crossref 10. The Deposition of Calcium Salts in Areas of Calcification , Watt Arch. Surg. 15:89 ( (July) ) 1927.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Sep 1, 1931

References