Calcifediol in Chronic Renal Insufficiency-Reply
Abstract
We appreciate the comments of Drs Coburn and Norman, particularly as regards the hypercalcemic potential of any analogue of vitamin D, illustrating the great care necessitated in using these compounds. We also concur that the superiority (if any) of one natural or synthetic analogue is yet to be proved, although there are little data in the report from Drs Coburn and Norman's group that 1,25-dihydroxycholecalciferol is effective in reversing the osteomalacic manifestations of uremic...