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Café-au-Lait Spots of the Fundus in Neurofibromatosis

Café-au-Lait Spots of the Fundus in Neurofibromatosis Abstract • Mild pigmentary changes found in the fundi of two patients with neurofibromatosis, resembled café-au-lait spots homologous with skin manifestations of the disease. In one, associated retinal hamartomas were present. The café-au-lait lesions were clinically distinct from previously reported uveal melanomas and may represent a hitherto unrecognized sign of ocular neurofibromatosis. (Arch Ophthalmol 95:1990-1993, 1977) References 1. Reese AB: Tumors of the peripheral nerves , in Tumors of the Eye , ed 3. Hagerstown, Md, Harper & Row Publishers Inc, 1976, pp 156-164. 2. Crowe FW, Schull WJ: Diagnostic importance of cafe-au-lait spots in neurofibromatosis . Arch Intern Med 91:758-766, 1953.Crossref 3. Gartner S: Malignant melanoma of the choroid in von Recklinghausen's disease . Am J Ophthalmol 23:73-78, 1940. 4. Strachov VP, Shepkalova VM: Recklinghausen's disease: Neurinoma of the right orbit and melanosarcoma of the left choroid . Vestn Oftamol 18:12-16, 1941. 5. Moorhouse JH: Case of neurofibroma of the choroid of acoustic nerve type . Trans Ophthalmol Soc UK 59:416-420, 1939. 6. Bain HL, Lore JG: Acoustic neurofibroma associated with melanoepithelioma of the choroid: Successful removal of both tumors . Mayo Clin Proc 12:481-485, 1937. 7. Nordmann J, Brini A: von Recklinghausen's disease and melanoma of the uvea . Br J Ophthalmol 54:641-648, 1970.Crossref 8. Reese AB: Meningioma , in Tumors of the Eye , ed 3. Hagerstown, Md, Harper & Row Publishers Inc, 1976, pp 150-151. 9. Martyn LJ, Knox DL: Glial hamartoma of the retina in generalized neurofibromatosis, von Rccklinghausen's disease . Br J Ophthalmol 56:487-491, 1972.Crossref 10. Dvorak-Theobald G: Neurogenic origin of neurogenic sarcoma . Arch Ophthalmol 18:971-997, 1937.Crossref 11. Masson P: Pigment cells in man , in Miner RW, Gordon M (eds): Biology of Melanomas . New York, New York Academy of Science, 1948, pp 15-51. 12. Font RL, Ferry AP: The phakomatoses . Int Ophthalmol Clin 12:1, 1972. 13. Berlinger W: Ein Beitrag zur epithelialen Genese des Melanins . Arch Pathol Anat 219:328-365, 1965.Crossref 14. Björneboe M: Primares Melanosarkom des Gehirns, massenhafte Naevi Pigmentosi der haut: Ansgedehnte Neurofibromatose der Hautnerven . Frankfurt Z Pathol 46:363-373, 1934. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Café-au-Lait Spots of the Fundus in Neurofibromatosis

Archives of Ophthalmology , Volume 95 (11) – Nov 1, 1977

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1977.04450110084007
Publisher site
See Article on Publisher Site

Abstract

Abstract • Mild pigmentary changes found in the fundi of two patients with neurofibromatosis, resembled café-au-lait spots homologous with skin manifestations of the disease. In one, associated retinal hamartomas were present. The café-au-lait lesions were clinically distinct from previously reported uveal melanomas and may represent a hitherto unrecognized sign of ocular neurofibromatosis. (Arch Ophthalmol 95:1990-1993, 1977) References 1. Reese AB: Tumors of the peripheral nerves , in Tumors of the Eye , ed 3. Hagerstown, Md, Harper & Row Publishers Inc, 1976, pp 156-164. 2. Crowe FW, Schull WJ: Diagnostic importance of cafe-au-lait spots in neurofibromatosis . Arch Intern Med 91:758-766, 1953.Crossref 3. Gartner S: Malignant melanoma of the choroid in von Recklinghausen's disease . Am J Ophthalmol 23:73-78, 1940. 4. Strachov VP, Shepkalova VM: Recklinghausen's disease: Neurinoma of the right orbit and melanosarcoma of the left choroid . Vestn Oftamol 18:12-16, 1941. 5. Moorhouse JH: Case of neurofibroma of the choroid of acoustic nerve type . Trans Ophthalmol Soc UK 59:416-420, 1939. 6. Bain HL, Lore JG: Acoustic neurofibroma associated with melanoepithelioma of the choroid: Successful removal of both tumors . Mayo Clin Proc 12:481-485, 1937. 7. Nordmann J, Brini A: von Recklinghausen's disease and melanoma of the uvea . Br J Ophthalmol 54:641-648, 1970.Crossref 8. Reese AB: Meningioma , in Tumors of the Eye , ed 3. Hagerstown, Md, Harper & Row Publishers Inc, 1976, pp 150-151. 9. Martyn LJ, Knox DL: Glial hamartoma of the retina in generalized neurofibromatosis, von Rccklinghausen's disease . Br J Ophthalmol 56:487-491, 1972.Crossref 10. Dvorak-Theobald G: Neurogenic origin of neurogenic sarcoma . Arch Ophthalmol 18:971-997, 1937.Crossref 11. Masson P: Pigment cells in man , in Miner RW, Gordon M (eds): Biology of Melanomas . New York, New York Academy of Science, 1948, pp 15-51. 12. Font RL, Ferry AP: The phakomatoses . Int Ophthalmol Clin 12:1, 1972. 13. Berlinger W: Ein Beitrag zur epithelialen Genese des Melanins . Arch Pathol Anat 219:328-365, 1965.Crossref 14. Björneboe M: Primares Melanosarkom des Gehirns, massenhafte Naevi Pigmentosi der haut: Ansgedehnte Neurofibromatose der Hautnerven . Frankfurt Z Pathol 46:363-373, 1934.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1977

References