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C-Reactive Protein in the Acute Phase of the Common Contagious Diseases

C-Reactive Protein in the Acute Phase of the Common Contagious Diseases Abstract Although C-reactive protein has been known for more than 20 years, general interest in it is of more recent date. This abnormal protein occurs in the blood of patients during the acute phase of certain diseases. It reacts with the C-carbohydrate of the Pneumococcus and was originally found in studies of patients with pneumonia. A number of investigators have studied the occurrence of C-reactive protein in the serum of patients with rheumatic fever. The other infectious diseases have been less well studied.* Papers have appeared dealing with tuberculosis,5 viral hepatitis,6 and allergy.8 The common diseases of childhood present a group of inflammations in which the occurrence of C-reactive protein (CRP) might be expected. As this is a quick and simple test which might well be useful in diagnosis and treatment, a survey was carried out on patients at Willard Parker Hospital. Not all of these patients were References 1. Ash, R.: Non-Specific Precipitins for Pneumococci Fraction C in Acute Infections , J. Infect. Dis. 53:89-97, 1933.Crossref 2. Lofstom, G.: Non-Specific Capsular Swelling in Pneumococci: A Serologic and Clinical Study , Acta med. scandinav. , (Supp. 141) , pp. 1-98, 1943. 3. Hedlund, P.: The Appearance of Acute Phase Proteins in Various Diseases , Acta med. scandinav. , (Supp. 196) , pp. 579-601, 1947. 4. Kelly, V. C.; Good, R. A., and McQuarrie, I.: Serum Mucoproteins in Children in Health and Disease with Special Reference to Rheumatic Fever , Pediatrics 5:824, 1950. 5. Shetlar, M. R.; Bullock, J. A.; Shetlar, C. L., and Payne, R. W.: Comparison of Serum C-Reactive Protein, Glycoprotein and Seromucoid in Cancer, Arthritis, Tuberculosis and Pregnancy , Proc. Soc. Exper. Biol. & Med. 88:107-109, 1955. 6. Havens, W. P., Jr.; Eichman, H. L., and Knowlton, M.: Failure to Find C-Reactive Protein in Viral Hepatitis , Proc. Soc. Exper. Biol. & Med. 75:108-110, 1950. 7. Abernethy, T. J., and Avery, O. T.: The Occurrence During Acute Infections of a Protein Not Normally Present in the Blood: I. Distribution of the Reactive Protein in Patients' Sera and the Effect of Calcium on the Flocculation Reaction with C Polysaccharide of Pneumococcus , J. Exper. Med. 73:173-182, 1941. 8. Smith, J. M., and Shaggs, J. T.: The C-Reactive Protein in Allergic Disease, J. Allergy, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

C-Reactive Protein in the Acute Phase of the Common Contagious Diseases

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1956.02060020152008
Publisher site
See Article on Publisher Site

Abstract

Abstract Although C-reactive protein has been known for more than 20 years, general interest in it is of more recent date. This abnormal protein occurs in the blood of patients during the acute phase of certain diseases. It reacts with the C-carbohydrate of the Pneumococcus and was originally found in studies of patients with pneumonia. A number of investigators have studied the occurrence of C-reactive protein in the serum of patients with rheumatic fever. The other infectious diseases have been less well studied.* Papers have appeared dealing with tuberculosis,5 viral hepatitis,6 and allergy.8 The common diseases of childhood present a group of inflammations in which the occurrence of C-reactive protein (CRP) might be expected. As this is a quick and simple test which might well be useful in diagnosis and treatment, a survey was carried out on patients at Willard Parker Hospital. Not all of these patients were References 1. Ash, R.: Non-Specific Precipitins for Pneumococci Fraction C in Acute Infections , J. Infect. Dis. 53:89-97, 1933.Crossref 2. Lofstom, G.: Non-Specific Capsular Swelling in Pneumococci: A Serologic and Clinical Study , Acta med. scandinav. , (Supp. 141) , pp. 1-98, 1943. 3. Hedlund, P.: The Appearance of Acute Phase Proteins in Various Diseases , Acta med. scandinav. , (Supp. 196) , pp. 579-601, 1947. 4. Kelly, V. C.; Good, R. A., and McQuarrie, I.: Serum Mucoproteins in Children in Health and Disease with Special Reference to Rheumatic Fever , Pediatrics 5:824, 1950. 5. Shetlar, M. R.; Bullock, J. A.; Shetlar, C. L., and Payne, R. W.: Comparison of Serum C-Reactive Protein, Glycoprotein and Seromucoid in Cancer, Arthritis, Tuberculosis and Pregnancy , Proc. Soc. Exper. Biol. & Med. 88:107-109, 1955. 6. Havens, W. P., Jr.; Eichman, H. L., and Knowlton, M.: Failure to Find C-Reactive Protein in Viral Hepatitis , Proc. Soc. Exper. Biol. & Med. 75:108-110, 1950. 7. Abernethy, T. J., and Avery, O. T.: The Occurrence During Acute Infections of a Protein Not Normally Present in the Blood: I. Distribution of the Reactive Protein in Patients' Sera and the Effect of Calcium on the Flocculation Reaction with C Polysaccharide of Pneumococcus , J. Exper. Med. 73:173-182, 1941. 8. Smith, J. M., and Shaggs, J. T.: The C-Reactive Protein in Allergic Disease, J. Allergy, to be published.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Feb 1, 1956

References