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Busulfan Treatment During Pregnancy

Busulfan Treatment During Pregnancy To the Editor:— In "Busulfan Treatment of Leukemia During Pregnancy" (199:131, 1967), Dugdale and Fort conclude, "Busulfan when used alone and in the usual dosage is not toxic to the human fetus." This conclusion is based upon two facts: (1) In all instances (ten cases) in which busulfan was the sole antileukemic agent used during pregnancy, the infants were apparently normal (although three were small). (2) The single dose that, administered to the rat, produces sterility in both male and female offspring1 is considerably higher than the daily doses used clinically; even the total dose is less in most patients. The authors noted, without comments, the report of Diamond, et al2 concerning an infant with ovarian aplasia whose mother took mercaptopurine and busulfan during pregnancy. It is possible that the conclusion of Dugdale and Fort is right, but I think that their arguments are questionable. We cannot http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Busulfan Treatment During Pregnancy

Machado, J. Pinto
JAMA , Volume 201 (4) – Jul 24, 1967
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Busulfan Treatment During Pregnancy

Abstract



To the Editor:—
In "Busulfan Treatment of Leukemia During Pregnancy" (199:131, 1967), Dugdale and Fort conclude, "Busulfan when used alone and in the usual dosage is not toxic to the human fetus." This conclusion is based upon two facts: (1) In all instances (ten cases) in which busulfan was the sole antileukemic agent used during pregnancy, the infants were apparently normal (although three were small). (2) The single dose that,...
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References (7)

Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1967.03130040068024
Publisher site
See Article on Publisher Site

Abstract

To the Editor:— In "Busulfan Treatment of Leukemia During Pregnancy" (199:131, 1967), Dugdale and Fort conclude, "Busulfan when used alone and in the usual dosage is not toxic to the human fetus." This conclusion is based upon two facts: (1) In all instances (ten cases) in which busulfan was the sole antileukemic agent used during pregnancy, the infants were apparently normal (although three were small). (2) The single dose that, administered to the rat, produces sterility in both male and female offspring1 is considerably higher than the daily doses used clinically; even the total dose is less in most patients. The authors noted, without comments, the report of Diamond, et al2 concerning an infant with ovarian aplasia whose mother took mercaptopurine and busulfan during pregnancy. It is possible that the conclusion of Dugdale and Fort is right, but I think that their arguments are questionable. We cannot

Journal

JAMA – American Medical Association

Published: Jul 24, 1967

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