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Bullous Pemphigoid and Dermatitis Herpetiformis: Histopathologic Differentiation of Bullous Pemphigoid and Dermatitis Herpetiformis

Bullous Pemphigoid and Dermatitis Herpetiformis: Histopathologic Differentiation of Bullous... Abstract This study deals with the histopathologic differentiation of dermatitis herpetiformis and bullous pemphigoid in 17 cases where the diagnoses were supported by immunofluorescent examinations. Two distinct patterns of inflammatory infiltration were observed in five cases of dermatitis herpetiformis, (1) papillary leukocytic infiltrates associated with leukocytoclasia and (2) perivascular mixed cellular infiltrates, with edema. In the 12 cases of bullous pemphigoid studied, two major histopathologic inflammatory patterns were also observed, (1) a dermal infiltrate-rich pattern and (2) a dermal infiltrate-poor pattern. References 1. Chorzelski TP, et al: Immunofluorescent studies in the diagnosis of dermatitis herpetiformis and its differentiation from bullous pemphigoid . J Invest Dermatol 56:373-380, 1971.Crossref 2. Jordon RE, et al: Basement zone antibodies in bullous pemphigoid . JAMA 200:751-756, 1967.Crossref 3. Pierard J, Whimster I: The histological diagnosis of dermatitis herpetiformis, bullous pemphigoid, and erythema multiforme . Br J Dermatol 73:253-266, 1961.Crossref 4. MacVicar DN, Graham JH, Burgoon CF: Dermatitis herpetiformis, erythema multiforme and bullous pemphigoid: A comparative histopathological and histochemical study . J Invest Dermatol 41:285-299, 1963.Crossref 5. Van der Meer JB: Dermatitis herpetiformis: A specific immunopathological entity . Utrecht UV, Netherland, Drukkeri; Batteljee VH, Terpstra, 1972, pp 45-82. 6. Connor BL, Marks R, Wilson-Jones E: Dermatitis herpetiformis: Histological discriminants . St John Hosp Derm Soc 58:191-198, 1972. 7. Allen AC: The Skin, a Clinopathological Treatise . St. Louis, The CV Mosby Co, 1954, pp 268-278. 8. Pinkus H, Mehregan A: A Guide to Dermatohistopathology . New York, Appleton-Century-Crofts, 1969, pp 144-146. 9. Pinkus H, Mehregan A: A Guide to Dermatopathology . New York, Appleton-Century-Crofts, 1969, pp 140. 10. Lever WF: Pemphigus: A histopathologic study . Arch Dermatol 64:727-753, 1951. 11. Lever WF: Pemphigus and Pemphigoid . Springfield, Ill, Charles C Thomas Publications, 1965, pp 85-99. 12. Montgomery H: Dermatopathology . New York, Harper & Row Publishers Inc, 1967, pp 154-165. 13. Lever WF: Histopathology of the Skin , ed 4. Philadelphia, JB Lippincott Co, 1967, pp 124-126. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Bullous Pemphigoid and Dermatitis Herpetiformis: Histopathologic Differentiation of Bullous Pemphigoid and Dermatitis Herpetiformis

Archives of Dermatology , Volume 110 (1) – Jul 1, 1974

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Publisher
American Medical Association
Copyright
Copyright © 1974 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1974.01630070019003
Publisher site
See Article on Publisher Site

Abstract

Abstract This study deals with the histopathologic differentiation of dermatitis herpetiformis and bullous pemphigoid in 17 cases where the diagnoses were supported by immunofluorescent examinations. Two distinct patterns of inflammatory infiltration were observed in five cases of dermatitis herpetiformis, (1) papillary leukocytic infiltrates associated with leukocytoclasia and (2) perivascular mixed cellular infiltrates, with edema. In the 12 cases of bullous pemphigoid studied, two major histopathologic inflammatory patterns were also observed, (1) a dermal infiltrate-rich pattern and (2) a dermal infiltrate-poor pattern. References 1. Chorzelski TP, et al: Immunofluorescent studies in the diagnosis of dermatitis herpetiformis and its differentiation from bullous pemphigoid . J Invest Dermatol 56:373-380, 1971.Crossref 2. Jordon RE, et al: Basement zone antibodies in bullous pemphigoid . JAMA 200:751-756, 1967.Crossref 3. Pierard J, Whimster I: The histological diagnosis of dermatitis herpetiformis, bullous pemphigoid, and erythema multiforme . Br J Dermatol 73:253-266, 1961.Crossref 4. MacVicar DN, Graham JH, Burgoon CF: Dermatitis herpetiformis, erythema multiforme and bullous pemphigoid: A comparative histopathological and histochemical study . J Invest Dermatol 41:285-299, 1963.Crossref 5. Van der Meer JB: Dermatitis herpetiformis: A specific immunopathological entity . Utrecht UV, Netherland, Drukkeri; Batteljee VH, Terpstra, 1972, pp 45-82. 6. Connor BL, Marks R, Wilson-Jones E: Dermatitis herpetiformis: Histological discriminants . St John Hosp Derm Soc 58:191-198, 1972. 7. Allen AC: The Skin, a Clinopathological Treatise . St. Louis, The CV Mosby Co, 1954, pp 268-278. 8. Pinkus H, Mehregan A: A Guide to Dermatohistopathology . New York, Appleton-Century-Crofts, 1969, pp 144-146. 9. Pinkus H, Mehregan A: A Guide to Dermatopathology . New York, Appleton-Century-Crofts, 1969, pp 140. 10. Lever WF: Pemphigus: A histopathologic study . Arch Dermatol 64:727-753, 1951. 11. Lever WF: Pemphigus and Pemphigoid . Springfield, Ill, Charles C Thomas Publications, 1965, pp 85-99. 12. Montgomery H: Dermatopathology . New York, Harper & Row Publishers Inc, 1967, pp 154-165. 13. Lever WF: Histopathology of the Skin , ed 4. Philadelphia, JB Lippincott Co, 1967, pp 124-126.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1974

References