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BROMINE CONTENT OF THE BLOOD IN MENTAL DISEASES: II. Manic-Depressive Psychosis

BROMINE CONTENT OF THE BLOOD IN MENTAL DISEASES: II. Manic-Depressive Psychosis Abstract IN A previous paper,1 a survey of the literature dealing with blood bromides in mental diseases was presented. Several investigators2 have made blood bromide studies of patients with manic-depressive psychosis. Zondek and Bier,2a in 1931, reported that in 29 out of 34 cases of manic-depressive psychosis studied the blood bromine content was from 40 to 60 per cent below the normal value (1 mg. per hundred cubic centimeters) established by them. These investigators obtained an average value of 0.572 mg. per hundred cubic centimeters for the 34 cases but did not state whether the patients were in the manic or in the depressed stage. Sacristán and Peraita2b analyzed the blood of 13 women classified as manic, hypomanic or melancholic and obtained bromine values ranging from 0.161 to 0.684 mg. per hundred cubic centimeters, with an average value of 0.423 mg. All these values were lower than References 1. Wikoff, H. L.; Martin, R. L., and Marvin, T. R.: Bromine Content of the Blood in Mental Diseases: I. Dementia Precox , Arch. Neurol. & Psychiat. 53:305 ( (April) ) 1945. 2. Zondek., H., and Bier, A.: Brom im Blute bei manisch-depressivem Irresein , Biochem. Ztschr. 241:491, 1931. 3. Sacristán, J. M., and Peraita, M.: Ueber den Bromspiegel des Blutes bei manisch-depressivem Irresein , Klin. Wchnschr. 12:469, 1933. 4. Hennelly, T. J., and Yates, E. D.: Blood Bromine in the Psychoses , J. Ment. Sc. 81:173, 1935. 5. Meier, C. A., and Schlientz, W.: Neuere Untersuchungen über den Bromspiegel im Blut bei Psychosen , Klin. Wchnschr. 15:1845, 1936. 6. Chatagon, P., and Chatagon, C.: Le métabolism du brome dans l'organisme humain , Compt. rend. Acad. d. sc. 202:1119, 1936. 7. Wikoff, H. L.; Bame, E., and Brandt, M.: A Method for the Determination of Bromide in a Protein-Free Filtrate , J. Lab. & Clin. Med. 24:427, 1939 8. Wikoff, H. L.; Brunner, R. A., and Allison, H. W.: The Normal Bromine Content of the Blood of Healthy Individuals , Am. J. Clin. Path. 10:234, 1940. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

BROMINE CONTENT OF THE BLOOD IN MENTAL DISEASES: II. Manic-Depressive Psychosis

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Publisher
American Medical Association
Copyright
Copyright © 1946 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1946.02300230067007
Publisher site
See Article on Publisher Site

Abstract

Abstract IN A previous paper,1 a survey of the literature dealing with blood bromides in mental diseases was presented. Several investigators2 have made blood bromide studies of patients with manic-depressive psychosis. Zondek and Bier,2a in 1931, reported that in 29 out of 34 cases of manic-depressive psychosis studied the blood bromine content was from 40 to 60 per cent below the normal value (1 mg. per hundred cubic centimeters) established by them. These investigators obtained an average value of 0.572 mg. per hundred cubic centimeters for the 34 cases but did not state whether the patients were in the manic or in the depressed stage. Sacristán and Peraita2b analyzed the blood of 13 women classified as manic, hypomanic or melancholic and obtained bromine values ranging from 0.161 to 0.684 mg. per hundred cubic centimeters, with an average value of 0.423 mg. All these values were lower than References 1. Wikoff, H. L.; Martin, R. L., and Marvin, T. R.: Bromine Content of the Blood in Mental Diseases: I. Dementia Precox , Arch. Neurol. & Psychiat. 53:305 ( (April) ) 1945. 2. Zondek., H., and Bier, A.: Brom im Blute bei manisch-depressivem Irresein , Biochem. Ztschr. 241:491, 1931. 3. Sacristán, J. M., and Peraita, M.: Ueber den Bromspiegel des Blutes bei manisch-depressivem Irresein , Klin. Wchnschr. 12:469, 1933. 4. Hennelly, T. J., and Yates, E. D.: Blood Bromine in the Psychoses , J. Ment. Sc. 81:173, 1935. 5. Meier, C. A., and Schlientz, W.: Neuere Untersuchungen über den Bromspiegel im Blut bei Psychosen , Klin. Wchnschr. 15:1845, 1936. 6. Chatagon, P., and Chatagon, C.: Le métabolism du brome dans l'organisme humain , Compt. rend. Acad. d. sc. 202:1119, 1936. 7. Wikoff, H. L.; Bame, E., and Brandt, M.: A Method for the Determination of Bromide in a Protein-Free Filtrate , J. Lab. & Clin. Med. 24:427, 1939 8. Wikoff, H. L.; Brunner, R. A., and Allison, H. W.: The Normal Bromine Content of the Blood of Healthy Individuals , Am. J. Clin. Path. 10:234, 1940.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Dec 1, 1946

References