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(1918)
Blaue Sclera, Knochenbrüchigkeit und SchwerhörigkeitArch. f. Ophth., 95
J. Hass (1919)
Zur Kenntniss der Osteopsathyrosis idiopathicaMed. Klin., 15
J. Spurway (1896)
Hereditary Tendency to FractureBritish Medical Journal, 2
A. Blencke (1924)
Ueber das gemeinsame VorkommenZtschr. f. orthop. Chir., 45
Holt and Howland (1922)
Diseases of Infancy and Childhood
W. Stobie (1924)
The Association of Blue Sclerotics With Brittle Bones and Progressive DeafnessQJM: An International Journal of Medicine
K. H. Bauer (1920)
Ueber Identität und Wesen der Sogenannten Osteopsathyrosis und Osteogenesis imperfectaDeutsche Ztschr. f. Chir., 160
E. Looser (1906)
Zur Kenntniss der Osteogenesis Imperfecta congenita et tardaMitt. a. d. Grenzgeb. d. Med. u. Chir., 15
N. Voorhoeve (1919)
Blue ScleroticsLancet, 2
O. Blegvad, H. Haxthausen (1921)
BLUE SCLEROTICS AND BRITTLE BONES, WITH MACULAR ATROPHY OF THE SKIN AND ZONULAR CATARACTBritish Medical Journal, 2
Buchanan (1903)
A Case of Maldevelopment of the Cornea and ScleroticTr. Ophth. Soc., 23
F. A. Conlon (1913)
Five Generations of Blue Sclerotics and Associated OsteoporosisBoston M. & S. J., 169
J. Van der Hoeve (1917)
Blauwe ScieraNederl. Tijdschr. v. Geneesk., 1
E. Weichmann (1925)
Zur Klinik der sogenannten blauen SklerenMünchen. med. Wchnschr., 72
H. W. Stenvers (1918)
Röntgenologische BemerkungenArch. f. Ophth., 95
A. Eddowes
Dark sclerotics and fragilitas ossium
C. Herrman (1915)
Blue Sclerotics and Brittle BonesAm. J. Dis. Child., 9
Peters (1913)
Blaue Sciera und KnochenbrüschigkeitKlin. Monatsbl f. Augenh., 51
S. Stephenson (1910)
A Peculiar Appearance of the EyesOphthalmoscope, 8
E. Cockayne
Hereditary Blue Sclerotics and Brittle Bones.Proceedings of the Royal Society of Medicine, 7 Sect Study Dis Child
S. Singer (1923)
Ein Beitrage zur Frage der Kombination abnormer Knochenbrüchigkeit und blaue SklerenZtschr. f. klin. Med., 97
E. Bronson (1917)
Fragilitas OssiumEdinburgh M. J., 18
N. B. Harman (1910)
A Pedigree of Five Generations of Blue ScleroticsOphthalmoscope, 8
F. Conlon (1913)
Five Generations of Blue Sclerotics and Associated OsteoporosisThe New England Journal of Medicine, 169
H. Burrows (1911)
BLUE SCLEROTICS AND BRITTLE BONESBritish Medical Journal, 2
Ruttin (1919)
Ohrbefund bei OsteopsathyrosisMonatschr. f. Ohrenh., 54
C. Davenport, H. Conard
Hereditary Fragility of Bone.Proceedings of the National Academy of Sciences of the United States of America, 1 10
J. Spurway (1917)
FRAGILITAS OSSIUM, BLUE SCLEROTICS, AND OTOSCLEROSISBritish Medical Journal, 1
Peters (1908)
Blaufärbung des AugapfelsKlin. Monatsbl f. Augenh., 46
M. Sumita (1910)
Beitrage zur Lehre von der Chondrodystrophia foetalis und Osteogenesis imperfectaDeutsche Ztschr. f. Chir., 107
H. Bolten (1923)
Blauwe ScleraeNederl. Tijdschr. v. Geneesk., 2
Abstract 1. INTRODUCTION Having had under treatment a typical case of that type of fragilitas ossium which is commonly called "brittle bones and blue sclera," I am in a position to describe for the first time the pathology of the condition, and to add certain clinical observations to those which are included in the rather extensive literature on the subject.The term "fragilitas ossium" is loosely applied to conditions that are characterized by an abnormal fragility of the bones. Bone fragility may be congenital or acquired, and may be due to developmental defects or to local or general absorption of the mineral constituents of normal bone. It is one of the most obscure subjects in modern medicine. The terminology is confused and the pathology is not well understood.Our knowledge is particularly vague in regard to the so-called idiopathic or developmental types of bone fragility. This includes three fairly well defined References 1. Spurway, J.: Hereditary Tendency to Fracture , Brit. M. J. 2:845, 1896.Crossref 2. Looser, E.: Zur Kenntniss der Osteogenesis Imperfecta congenita et tarda , Mitt. a. d. Grenzgeb. d. Med. u. Chir. 15:161, 1906. 3. Sumita, M.: Beitrage zur Lehre von der Chondrodystrophia foetalis und Osteogenesis imperfecta , Deutsche Ztschr. f. Chir. 107:1, 1910.Crossref 4. Bauer, K. H.: Ueber Identität und Wesen der Sogenannten Osteopsathyrosis und Osteogenesis imperfecta , Deutsche Ztschr. f. Chir. 160:289, 1920.Crossref 5. Bronson, E.: Fragilitas Ossium , Edinburgh M. J. 18:240 ( (April) ) 1917. 6. Eddowes, A.: Dark Sclerotics and Fragilitas Ossium , Brit. M. J. 2:222, 1900. 7. Spurway, J.: Fragilitas Ossium, Blue Sclerotics and Otosclerosis , Brit. M. J. 1:826, 1917.Crossref 8. Peters: Blaufärbung des Augapfels , Klin. Monatsbl f. Augenh. 46:130, 1908 9. Blaue Sciera und Knochenbrüschigkeit , Peters Klin. Monatsbl f. Augenh. 51:524, 1913. 10. Van der Hoeve, J., and de Kleijn, A.: Blauwe Sciera , Nederl. Tijdschr. v. Geneesk. 1:1003 ( (March 31) ) 1917 11. Blaue Sclera, Knochenbrüchigkeit und Schwerhörigkeit , Arch. f. Ophth. 95:81, 1918. 12. Voorhoeve, N.: Blue Sclerotics , Lancet 2:740, 1919. 13. Bolten, H.: Blauwe Sclerae , Nederl. Tijdschr. v. Geneesk. 2:1747, 1923. 14. Conard, H. S., and Davenport, C. B.: Hereditary Fragility of Bone , Eugenics Record Office Bull. 14, 1915, Cold Spring Harbor, N. Y. 15. De Kleijn (footnote 9, second reference). 16. Ruttin: Ohrbefund bei Osteopsathyrosis , Monatschr. f. Ohrenh. 54:305, 1919. 17. Stephenson, S.: A Peculiar Appearance of the Eyes , Ophthalmoscope 8:330, 1910. 18. Harman, N. B.: A Pedigree of Five Generations of Blue Sclerotics , Ophthalmoscope 8:559, 1910. 19. Cockayne, E. A.: Hereditary Blue Sclerotics and Brittle Bones , Ophthalmoscope 12:271, 1914. 20. Singer, S.: Ein Beitrage zur Frage der Kombination abnormer Knochenbrüchigkeit und blaue Skleren , Ztschr. f. klin. Med. 97:43 ( (May) ) 1923. 21. Weichmann, E., and Pool, H.: Zur Klinik der sogenannten blauen Skleren , München. med. Wchnschr. 72:213, 1925. 22. Hass, J.: Zur Kenntniss der Osteopsathyrosis idiopathica , Med. Klin. 15:1112, 1919. 23. Blencke, A.: Ueber das gemeinsame Vorkommen , Ztschr. f. orthop. Chir. 45:406, 1924. 24. Holt and Howland: Diseases of Infancy and Childhood , New York, 1922, p. 23. 25. Stenvers, H. W.: Röntgenologische Bemerkungen , Arch. f. Ophth. 95:94, 1918. 26. Stobie, W.: The Association of Blue Sclerotics with Brittle Bones and Progressive Deafness , Quart. J. Med. 17:274 ( (April) ) 1924.Crossref 27. Conlon, F. A.: Five Generations of Blue Sclerotics and Associated Osteoporosis , Boston M. & S. J. 169:16, 1913. 28. Herrman, C.: Blue Sclerotics and Brittle Bones , Am. J. Dis. Child. 9:203 ( (March) ) 1915. 29. Buchanan: A Case of Maldevelopment of the Cornea and Sclerotic , Tr. Ophth. Soc. 23:267, 1903 30. Ophthalmoscope 8:685, 1910. 31. Behr, C.: Beitrage zur Aetiologie des Keratoconus , Klin. Monatsbl. f. Augenh. 51:281, 1913. 32. Ostheimer, M.: Fragilitas Ossium , J. A. M. A. 63:1996, 1914. 33. Hoffmann, W.: Ueber Blaufärbung der Skiera und abnorme Knochenbrüchigkeit , Arch. f. klin. Chir. 107:279, 1915. 34. Gutzeit, R.: Ueber blaue Skiera und Knochenbrüchigkeit , Klin. Monatsbl. f. Augenh. 68:171, 1922. 35. Adair-Dighton, C. A.: Four Generations of Blue Sclerotics , Ophthalmoscope 10:188, 1912. 36. Straat, H. L.: Blauwe Sclerae, Fragilitas Ossium en Otosklerose , Nederl. Tijdschr. v. Geneesk. 1:152 ( (Jan. 13) ) 1923. 37. Freytag: Ueber blaue Skiera u. Knochenbrüchigkeit , Klin. Monatsbl. f. Augenh. 66:507, 1921. 38. Terry, W. I.: Hereditary Osteopsathyrosis , Ann. Surg. 68:231 ( (Aug.) ) 1918. 39. Reye: Ueber diffuse Blaufarbung der Skiera , Deutsche med. Wchnschr. 4:125, 1917. 40. Marconi, A.: Gazz. d. osp. 39:367 ( (May 9) ) 1918 41. abstr., J. A. M. A. 71:319 ( (July 27) ) 1918. 42. Wells, H. G.: Metastatic Calcification , Arch. Int. Med. 15:574 ( (April) ) 1916. 43. Blegvad, O., and Haxthausen, H.: Blue Sclerotics and Brittle Bones, with Macular Atrophy of the Skin and Zonular Cataract , Brit. M. J. 2:1071 ( (Dec. 24) ) 1921. 44. Vander Veer, E. A., and Dickinson, A. M.: Fragilitas Ossium , Ann. Surg. 74:629 ( (Nov.) ) 1921.Crossref 45. Crocco: Blau sklera , Comm. d. Hosp. Ophth. Buenos Aires 2:38, 1920 46. Bolten, G. C.: Het Voorkomen von blauwe Sclerae , Nederl. Tijdschr. v. Geneesk. 1:560 ( (Feb. 23) ) 1918. 47. Glover, D. M.: Osteopsathyrosis , Arch. Surg. 5:464 ( (Nov.) ) 1922.Crossref 48. Davis, G. G.: Osteosclerosis Fragilis Generalisata , Arch. Surg. 5:449 ( (Nov.) ) 1922.Crossref
Archives of Surgery – American Medical Association
Published: Oct 1, 1926
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