ORIGINAL ARTICLE Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder A Randomized Placebo-Controlled Trial Ritsaert Lieverse, MD; Eus J. W. Van Someren, PhD; Marjan M. A. Nielen, PhD; Bernard M. J. Uitdehaag, MD, PhD; Jan H. Smit, PhD; Witte J. G. Hoogendijk, MD, PhD Context: Major depressive disorder (MDD) in elderly Main Outcome Measures: Mean improvement in Hamilton Scale for Depression scores at T1 and T2 using individuals is prevalent and debilitating. It is accompa- parameters of sleep and cortisol and melatonin levels. nied by circadian rhythm disturbances associated with impaired functioning of the suprachiasmatic nucleus, the Results: Intention-to-treat analysis showed Hamilton Scale biological clock of the brain. Circadian rhythm distur- for Depression scores to improve with BLT more than pla- bances are common in the elderly. Suprachiasmatic cebo from T0 to T1 (7%; 95% confidence interval, 4%- nucleus stimulation using bright light treatment (BLT) 23%; P =.03) and from T0 to T2 (21%; 7%-31%; P = .001). may, therefore, improve mood, sleep, and hormonal At T1 relative to T0, get-up time after final awakening in rhythms in elderly patients with MDD. the BLT group advanced by 7% (P .001), sleep effi- ciency increased by 2%
JAMA Psychiatry – American Medical Association
Published: Jan 1, 2011
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