Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder

Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder ORIGINAL ARTICLE Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder A Randomized Placebo-Controlled Trial Ritsaert Lieverse, MD; Eus J. W. Van Someren, PhD; Marjan M. A. Nielen, PhD; Bernard M. J. Uitdehaag, MD, PhD; Jan H. Smit, PhD; Witte J. G. Hoogendijk, MD, PhD Context: Major depressive disorder (MDD) in elderly Main Outcome Measures: Mean improvement in Hamilton Scale for Depression scores at T1 and T2 using individuals is prevalent and debilitating. It is accompa- parameters of sleep and cortisol and melatonin levels. nied by circadian rhythm disturbances associated with impaired functioning of the suprachiasmatic nucleus, the Results: Intention-to-treat analysis showed Hamilton Scale biological clock of the brain. Circadian rhythm distur- for Depression scores to improve with BLT more than pla- bances are common in the elderly. Suprachiasmatic cebo from T0 to T1 (7%; 95% confidence interval, 4%- nucleus stimulation using bright light treatment (BLT) 23%; P =.03) and from T0 to T2 (21%; 7%-31%; P = .001). may, therefore, improve mood, sleep, and hormonal At T1 relative to T0, get-up time after final awakening in rhythms in elderly patients with MDD. the BLT group advanced by 7% (P .001), sleep effi- ciency increased by 2% http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder

Loading next page...
 
/lp/american-medical-association/bright-light-treatment-in-elderly-patients-with-nonseasonal-major-7NbGwRI3vx
Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2010.183
pmid
21199966
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Bright Light Treatment in Elderly Patients With Nonseasonal Major Depressive Disorder A Randomized Placebo-Controlled Trial Ritsaert Lieverse, MD; Eus J. W. Van Someren, PhD; Marjan M. A. Nielen, PhD; Bernard M. J. Uitdehaag, MD, PhD; Jan H. Smit, PhD; Witte J. G. Hoogendijk, MD, PhD Context: Major depressive disorder (MDD) in elderly Main Outcome Measures: Mean improvement in Hamilton Scale for Depression scores at T1 and T2 using individuals is prevalent and debilitating. It is accompa- parameters of sleep and cortisol and melatonin levels. nied by circadian rhythm disturbances associated with impaired functioning of the suprachiasmatic nucleus, the Results: Intention-to-treat analysis showed Hamilton Scale biological clock of the brain. Circadian rhythm distur- for Depression scores to improve with BLT more than pla- bances are common in the elderly. Suprachiasmatic cebo from T0 to T1 (7%; 95% confidence interval, 4%- nucleus stimulation using bright light treatment (BLT) 23%; P =.03) and from T0 to T2 (21%; 7%-31%; P = .001). may, therefore, improve mood, sleep, and hormonal At T1 relative to T0, get-up time after final awakening in rhythms in elderly patients with MDD. the BLT group advanced by 7% (P .001), sleep effi- ciency increased by 2%

Journal

JAMA PsychiatryAmerican Medical Association

Published: Jan 1, 2011

References