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Breast-feeding and Salmonella Infection

Breast-feeding and Salmonella Infection Abstract • Various assays were used to examine chemotaxis, opsonization, phagocytosis, and killing of Salmonella organisms by colostral and breast-milk components. Vigorous responses of colostral and milk cells against this organism and nonspecific opsonizing capacity of the aqueous phase of colostrum and milk were demonstrated. An assay with acridine orange was used to directly visualize the phagocytic and killing processes; colostral and milk cells were demonstrated to be more active against Salmonella than blood neutrophils. In a restrospective survey, a diagnosis of Salmonella infection was confirmed in 253 infants less then 1 year of age. Only 12 infants had ever been breast-fed, and only one near the time he had the disease. During the same period of time, 27% of matched control infants were breast-fed. (Am J Dis Child 134:147-152, 1980) References 1. Larsen SA Jr, Homer DR: Relation of breast versus bottle feeding to hospitalization for gastroenteritis in a middle-class US population . J Pediatr 92:417-418, 1978.Crossref 2. Cunningham AS: Morbidity in breast-fed and artifically fed infants . J Pediatr 90:726-729, 1977.Crossref 3. Barness LA, Mauer AM, Anderson AS, et al: Breast-feeding: A commentary in celebration of the international year of the child, 1979 . Pediatrics 62:591-601, 1978. 4. Hanson LA, Winberg J: Breast milk and defense against infection in the newborn . Arch Dis Child 47:845-847, 1972.Crossref 5. Mata LH, Urrutia JJ, Gordon JE: Diarrheal disease in a cohort of Guatemalan village children observed from birth to age 2 years . Trop Geogr Med 19:247-251, 1967. 6. Ho PC, Lawton JWM: Human colostral cells: Phagocytosis and killing of E coli and C albicans . J Pediatr 93:910-915, 1978.Crossref 7. Robinson JE, Harvey BAM, Soothill JF: Phagocytosis and killing of bacteria and yeast by human milk cells after opsonization in aqueous phase of milk . Br Med J 1:1443-1445, 1978.Crossref 8. Ogra SS, Ogra PL: Immunologic aspects of human colostrum and milk . J Pediatr 92:550-555, 1978.Crossref 9. Miller ME: Host defenses in the human neonate . Pediatr Clin North Am 24:413-423, 1977. 10. Lepow ML, Warren RJ, Guay N, et al: Effect of Sabin type 1 poliomyelitis vaccine administered by mouth to newborn infants . N Engl J Med 264:1071-1075, 1961.Crossref 11. Hodes H: The etiology of infantile diarrhea . Adv Pediatr 8:13-19, 1956. 12. Neter E: Enteritis due to enteropathogenic Escherichia coli . J Pediatr 55:223-229, 1959.Crossref 13. Goldman AS, Smith CW: Host resistance factors in human milk . J Pediatr 82:1082-1090, 1973.Crossref 14. Mata LJ, Urrutia JJ, Garcia B, et al: Shigella infection in breast-fed Guatemalan Indian neonates . Am J Dis Child 117:142-146, 1969. 15. Fox MD, Loewenstein MS, Martin SM: Salmonella surveillance: 1970 . J Infect Dis 125:196-198, 1972.Crossref 16. Nelson RD, Quie PG, Simmons RL: Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes . J Immunol 115:1650-1654, 1975. 17. Feigin RD, Shackelford PG, Choi SC, et al: Nitroblue tetrazolium dye test as an aid in the differential diagnosis of febrile disorders . J Pediatr 78:230-237, 1971.Crossref 18. Quie PG, White JG, Holmes B, et al: In vitro bactericidal capacity of human polymorphonuclear leukocytes: Diminished activity in chronic granulomatous disease of childhood . J Clin Invest 16:668-674, 1967.Crossref 19. Smith DL, Rommel F: A rapid micro method for the simultaneous determination of phagocytic-microbicidal activity of human peripheral blood leukocytes in vitro . J Immunol Methods 17:241-249, 1977.Crossref 20. Allen RC: Evaluation of serum opsonic capacity by quantitating the initial chemiluminescent response from phagocytizing polymorphonuclear leukocytes . Infect Immunol 15:828-833, 1977. 21. Pittard WB III: Breast milk immunology: A frontier in infant nutrition . Am J Dis Child 133:83-87, 1979.Crossref 22. Smith CW, Goldman AS: The cells of human colostrum: I. In vitro studies of morphology and function . Pediatr Res 2:103-109, 1968.Crossref 23. Lascelles AK, Gurner BW, Coombs RRA: Some properties of human colostral cells . Aust J Exp Biol Med Sci 47:349-352, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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References (24)

Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130140021007
Publisher site
See Article on Publisher Site

Abstract

Abstract • Various assays were used to examine chemotaxis, opsonization, phagocytosis, and killing of Salmonella organisms by colostral and breast-milk components. Vigorous responses of colostral and milk cells against this organism and nonspecific opsonizing capacity of the aqueous phase of colostrum and milk were demonstrated. An assay with acridine orange was used to directly visualize the phagocytic and killing processes; colostral and milk cells were demonstrated to be more active against Salmonella than blood neutrophils. In a restrospective survey, a diagnosis of Salmonella infection was confirmed in 253 infants less then 1 year of age. Only 12 infants had ever been breast-fed, and only one near the time he had the disease. During the same period of time, 27% of matched control infants were breast-fed. (Am J Dis Child 134:147-152, 1980) References 1. Larsen SA Jr, Homer DR: Relation of breast versus bottle feeding to hospitalization for gastroenteritis in a middle-class US population . J Pediatr 92:417-418, 1978.Crossref 2. Cunningham AS: Morbidity in breast-fed and artifically fed infants . J Pediatr 90:726-729, 1977.Crossref 3. Barness LA, Mauer AM, Anderson AS, et al: Breast-feeding: A commentary in celebration of the international year of the child, 1979 . Pediatrics 62:591-601, 1978. 4. Hanson LA, Winberg J: Breast milk and defense against infection in the newborn . Arch Dis Child 47:845-847, 1972.Crossref 5. Mata LH, Urrutia JJ, Gordon JE: Diarrheal disease in a cohort of Guatemalan village children observed from birth to age 2 years . Trop Geogr Med 19:247-251, 1967. 6. Ho PC, Lawton JWM: Human colostral cells: Phagocytosis and killing of E coli and C albicans . J Pediatr 93:910-915, 1978.Crossref 7. Robinson JE, Harvey BAM, Soothill JF: Phagocytosis and killing of bacteria and yeast by human milk cells after opsonization in aqueous phase of milk . Br Med J 1:1443-1445, 1978.Crossref 8. Ogra SS, Ogra PL: Immunologic aspects of human colostrum and milk . J Pediatr 92:550-555, 1978.Crossref 9. Miller ME: Host defenses in the human neonate . Pediatr Clin North Am 24:413-423, 1977. 10. Lepow ML, Warren RJ, Guay N, et al: Effect of Sabin type 1 poliomyelitis vaccine administered by mouth to newborn infants . N Engl J Med 264:1071-1075, 1961.Crossref 11. Hodes H: The etiology of infantile diarrhea . Adv Pediatr 8:13-19, 1956. 12. Neter E: Enteritis due to enteropathogenic Escherichia coli . J Pediatr 55:223-229, 1959.Crossref 13. Goldman AS, Smith CW: Host resistance factors in human milk . J Pediatr 82:1082-1090, 1973.Crossref 14. Mata LJ, Urrutia JJ, Garcia B, et al: Shigella infection in breast-fed Guatemalan Indian neonates . Am J Dis Child 117:142-146, 1969. 15. Fox MD, Loewenstein MS, Martin SM: Salmonella surveillance: 1970 . J Infect Dis 125:196-198, 1972.Crossref 16. Nelson RD, Quie PG, Simmons RL: Chemotaxis under agarose: A new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes . J Immunol 115:1650-1654, 1975. 17. Feigin RD, Shackelford PG, Choi SC, et al: Nitroblue tetrazolium dye test as an aid in the differential diagnosis of febrile disorders . J Pediatr 78:230-237, 1971.Crossref 18. Quie PG, White JG, Holmes B, et al: In vitro bactericidal capacity of human polymorphonuclear leukocytes: Diminished activity in chronic granulomatous disease of childhood . J Clin Invest 16:668-674, 1967.Crossref 19. Smith DL, Rommel F: A rapid micro method for the simultaneous determination of phagocytic-microbicidal activity of human peripheral blood leukocytes in vitro . J Immunol Methods 17:241-249, 1977.Crossref 20. Allen RC: Evaluation of serum opsonic capacity by quantitating the initial chemiluminescent response from phagocytizing polymorphonuclear leukocytes . Infect Immunol 15:828-833, 1977. 21. Pittard WB III: Breast milk immunology: A frontier in infant nutrition . Am J Dis Child 133:83-87, 1979.Crossref 22. Smith CW, Goldman AS: The cells of human colostrum: I. In vitro studies of morphology and function . Pediatr Res 2:103-109, 1968.Crossref 23. Lascelles AK, Gurner BW, Coombs RRA: Some properties of human colostral cells . Aust J Exp Biol Med Sci 47:349-352, 1969.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Feb 1, 1980

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